A Retrospective Evaluation of Cutaneous Adverse Drug Reactions (CADRs) Due to Antibiotics Using Naranjo Adverse Drug Reactions (ADRs) Probability Scale

Shalayel, Mohammed Helmy Faris; Ayed, Ietimad Abdelsalam Mohamed; Kordofani, Yousif M

doi:10.5530/jyp.2018.10.25

“…Indeed, items 6 to 10 were scored “do not know” for most drugs because data were not most often available. This issue was raised by other authors 41,42…”

Section: Limitations Of the Studymentioning

confidence: 88%

<p>Community-Acquired Acute Kidney Injury Induced By Drugs In Older Patients: A Multifactorial Event</p>

Robert¹,

Ficheur²,

Gautier³

et al. 2019

CIA

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PurposeCommunity-acquired acute kidney injury (CA-AKI) is a frequent and severe adverse drug reaction (ADR) among older patients. The combination of drugs and other CA-AKI risk factors was barely evaluated. The objectives of our study were to both accurately identify CA-AKI induced by drugs in older patients, and to describe their combination with other risk factors.Patients and methodsWe conducted a retrospective, single-center study in a general hospital over a two-year period. An automated detection identified CA-AKI according to KDIGO criteria, amongst 4,767 eligible inpatient stays among patients aged 75 years or older. Two independent experts reviewed all CA-AKI events to adjudicate drug involvement (Naranjo scale), identify inappropriate prescriptions (STOPP criteria), evaluate avoidability (Hallas criteria) and identify combined risk factors.ResultsAn expert review confirmed 713 CA-AKI (15.0% of inpatient stays) and determined that 419 (58.8%) CA-AKI were induced by drugs. A multifactorial cause (i.e., at least one drug with a precipitating factor) was found in 63.2% of drug-induced CA-AKI. Most of the drug-induced events were avoidable (66.8%), mainly in relation to a multifactorial cause.ConclusionDrug-induced CA-AKI were frequent, multifactorial events in hospitalized older patients and their prevention should focus on combinations with precipitating factors.

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“…A retrospective descriptive study in a teaching hospital in Sudan found significant numbers of severe cADRs involving various antibiotics where ciprofloxacin was the greatest offender (41.46% of FDE, EM-Major, SJS and TEN). Other ABs or AMs involved were artesunate (12.2% of EM-Major, SJS, TEN), penicillin (7.32% of EM-Major, SJS), sulfamethoxazole-trimethoprim (7.32% of SJS, TEN, SJS/TEN overlap), norfloxacin (7.32% of TEN), amoxycillin (4.88% of SJS, TEN), ceftriaxone (4.88% of SJS, TEN) and ampicillin-cloxacillin, amoxicillin-clavulanic acid, Fansidar (sulfadoxine and pyrimethamine), erythromycin, clarithromycin and tetracycline caused 2.4% each of SJS, TEN and EM-Major reactions [101]. There is a wide variation in the frequency of various types of cADRs in the studies reviewed.…”

Section: Juniper Online Journal Of Dermatology and Cosmeticsmentioning

confidence: 99%

Untitled

2023

JOJDC

0

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Medication-related harm or adverse drug reaction is a great global health concern today. They are frequent and, most often, devastating. With the rising incidences of drug-related adverse outcomes, it is imperative that clinicians have the knowledge and understanding of these occurrences to prevent, diagnose, and manage them properly. Skin is a very commonly affected organ system, and incidences of cutaneous adverse drug reactions are between 1-5% depending on the geographic location. Up to 60% or more of all adverse drug reactions may represent cutaneous reactions. These may fall into either of the dose-dependent or dose-independent categories. Being the most prescribed and utilized drug group, antibiotics have been implicated as one of the major drug groups causing cutaneous drug reactions. There is ample evidence that antibiotics cause severe and non-severe cutaneous adverse drug reactions. A review of the present literature was done using MEDLINE/PubMed, Google Scholar, and other search engines to gather evidence to find how extensive the problem is and how much the burden is. Which will enlighten clinicians from all backgrounds and medical students and help them deal with cutaneous adverse drug reactions more prudently.

show abstract

“…A retrospective descriptive study in a teaching hospital in Sudan found significant numbers of severe cADRs involving various antibiotics where ciprofloxacin was the greatest offender (41.46% of FDE, EM-Major, SJS and TEN). Other ABs or AMs involved were artesunate (12.2% of EM-Major, SJS, TEN), penicillin (7.32% of EM-Major, SJS), sulfamethoxazole-trimethoprim (7.32% of SJS, TEN, SJS/TEN overlap), norfloxacin (7.32% of TEN), amoxycillin (4.88% of SJS, TEN), ceftriaxone (4.88% of SJS, TEN) and ampicillin-cloxacillin, amoxicillin-clavulanic acid, Fansidar (sulfadoxine and pyrimethamine), erythromycin, clarithromycin and tetracycline caused 2.4% each of SJS, TEN and EM-Major reactions [101]. There is a wide variation in the frequency of various types of cADRs in the studies reviewed.…”

Section: Juniper Online Journal Of Dermatology and Cosmeticsmentioning

confidence: 99%

Cutaneous Adverse Drug Reactions to Antibiotics: How Much is the Extent of the Problem?

Uddin Umar

2023

JOJDC

0

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Medication-related harm or adverse drug reaction is a great global health concern today. They are frequent and, most often, devastating. With the rising incidences of drug-related adverse outcomes, it is imperative that clinicians have the knowledge and understanding of these occurrences to prevent, diagnose, and manage them properly. Skin is a very commonly affected organ system, and incidences of cutaneous adverse drug reactions are between 1-5% depending on the geographic location. Up to 60% or more of all adverse drug reactions may represent cutaneous reactions. These may fall into either of the dose-dependent or dose-independent categories. Being the most prescribed and utilized drug group, antibiotics have been implicated as one of the major drug groups causing cutaneous drug reactions. There is ample evidence that antibiotics cause severe and non-severe cutaneous adverse drug reactions. A review of the present literature was done using MEDLINE/PubMed, Google Scholar, and other search engines to gather evidence to find how extensive the problem is and how much the burden is. Which will enlighten clinicians from all backgrounds and medical students and help them deal with cutaneous adverse drug reactions more prudently

show abstract

A Retrospective Evaluation of Cutaneous Adverse Drug Reactions (CADRs) Due to Antibiotics Using Naranjo Adverse Drug Reactions (ADRs) Probability Scale

Cited by 4 publications

References 22 publications

<p>Community-Acquired Acute Kidney Injury Induced By Drugs In Older Patients: A Multifactorial Event</p>

<p>Community-Acquired Acute Kidney Injury Induced By Drugs In Older Patients: A Multifactorial Event</p>

Untitled

Cutaneous Adverse Drug Reactions to Antibiotics: How Much is the Extent of the Problem?

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