A Retrospective Epidemiological Analysis of Fungal Infections of Skin and Soft Tissue in a Health Care Setup in Delhi, India

Butta, Hena; Sardana, Raman; Mendiratta, Leena; Singh, Vyoma; Jasuja, Sanjiv; Tandon, H. O.; Kashyap, Vikas

doi:10.7860/jcdr/2018/35798.11987

Cited by 2 publications

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“…However, the diagnosis of mucormycosis depends on histopathology and culture. Mucormycosis readily invades blood vessels and destroys the tissue of affected organs, leading to vascular thrombosis and tissue necrosis with the formation of black crusts [16]. Hematoxylin-eosin (HE) staining, hyperoside (PAS) staining, and hexosamine silver staining can be selected for definite infection, with hexosamine silver staining being preferred, and may show broad, irregular hyphae in tissue specimen sections without separation or with little separation or righting branching [17].…”

Section: Discussionmentioning

confidence: 99%

Application Value of Metagenomics Next-Generation Sequencing (mNGS) in Detection of Mucormycosis after Chemotherapy in Childhood Acute Leukemia

Zhu

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To analyze the application of macrogenomics next-generation sequencing (mNGS) in the detection of postchemotherapy trichomoniasis cases in children with acute leukemia. Methods. To retrospectively analyze the clinical data of 7 patients with acute leukemia combined with trichomoniasis after chemotherapy in the department of hematology and oncology of Hebei Children’s Hospital, and to summarize the characteristics of their postchemotherapy clinical data, diagnostic and therapeutic processes, and outcomes. Results. Among the 7 children, 6 cases had acute lymphoblastic leukemia and 1 case had acute myeloid leukemia. mNGS detected trichoderma infection, including 1 case of pulmonary cerebral type and 6 cases of pulmonary type. After treatment, 1 case died, 2 cases were cured, and 4 cases improved. Conclusion . The clinical manifestations of trichomoniasis after combined chemotherapy in pediatric acute leukemia lack specificity. Early application of the mNGS assay is of great value.

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Section: Discussionmentioning

confidence: 99%

Application Value of Metagenomics Next-Generation Sequencing (mNGS) in Detection of Mucormycosis after Chemotherapy in Childhood Acute Leukemia

Zhu

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…A similar study from India also reported fungal isolation in 37 out of 288 (12.8%) pus and tissue samples, of which 24 were yeast and 13 were moulds. 7 Burns and blast wounds had the highest proportion of fungal isolates [2 out of 4 (50%)] followed by traumatic wounds [1 of 12 (8%)] in current study. A high rate of fungal isolation in burn patients [27 of 70 (39%)] has also been reported from Pakistan which is consistent with global data and the current study.…”

Section: Discussionmentioning

confidence: 52%

Fungal isolation from wound samples submitted for culture at a tertiary care hospital laboratory

et al. 2022

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Fungal wound infections are increasing worldwide. The aim of this retrospective study, conducted at the Aga Khan University laboratory, Karachi, Pakistan, was to determine the frequency of fungal isolation in wound specimens. Data of wound samples received for culture from all over the country between September and October 2018 was reviewed. Samples were processed for bacterial cultures and additionally inoculated on Sabouraud’s dextrose medium. Demographic information, medical history and information on the type of wound was collected. A total of 140 cases were included, of which 87 (81%) were culture positive, while 10 (7%) cases yielded fungi. Burn and blast wounds had the highest proportion of fungal isolation, i.e. 2 out of 4 (50%). Candida species were the most common fungi (n=4), followed by Fusarium species (n=3). This study reports an alarming rate of fungal wound infections. As fungal necrotising wound infections have high morbidity and mortality, it is, therefore, important to accurately diagnose and treat such infections in local setting. Keywords: Wounds and Injuries, Fungal Infections, Diabetic Foot, Infections, Skin and Soft Tissue Infections.

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A Retrospective Epidemiological Analysis of Fungal Infections of Skin and Soft Tissue in a Health Care Setup in Delhi, India

Cited by 2 publications

References 0 publications

Application Value of Metagenomics Next-Generation Sequencing (mNGS) in Detection of Mucormycosis after Chemotherapy in Childhood Acute Leukemia

Application Value of Metagenomics Next-Generation Sequencing (mNGS) in Detection of Mucormycosis after Chemotherapy in Childhood Acute Leukemia

Fungal isolation from wound samples submitted for culture at a tertiary care hospital laboratory

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