A retrospective controlled study of thiol disulfide homeostasis as a novel marker in Crimean Congo hemorrhagic fever

Abstract

This is the first study in the literature to evaluate dynamic TDH in CCHF. TDH shifts to the oxidative side in patients with CCHF, leading to an increase in TOS.

Impaired Thiol-Disulfide Balance in Acute Brucellosis

“…The role and importance of thiol-disulfide homeostasis have been reported in several infectious diseases such as Crimean-Congo hemorrhagic fever and acute tonsillopharyngitis (21,22). Altered thiol-disulfide balances were observed in both studies.…”

“…Thiol-disulfide balances were found to be shifted to the oxidative side in both studies (21,22). There were positive or negative relationships between thiol-disulfide < 0.001 < 0.001 ≥ 0.05 < 0.001 < 0.001 < 0.001…”

“…Thiol-disulfide homeostasis has also been evaluated in various infectious diseases such as Crimean-Congo hemorrhagic fever and acute tonsillopharyngitis (21,22). Thiol-disulfide balances were found to be shifted to the oxidative side in both studies (21,22).…”

“…Control group Brucellosis tests and some other well-known oxidant, and antioxidant parameters, including total antioxidant status, total oxidant status, paraoxonase, arylesterase, and ceruloplasmin in Crimean-Congo hemorrhagic fever (21). In acute tonsillopharyngitis, C-reactive protein values and white blood cell counts were negatively correlated with the native and total thiol levels (22).…”

Thiol/disulfide homeostasis as a novel inflammatory marker in vitiligo

“…Thiol/disulfit homeostazı (TDH) anti-oksidan korunma, detoksifikasyon, hücre büyümesi ve aopopitozu gibi birçok hücresel aktivitede kritik role sahiptir (10,11) . Daha önceleri prediabet, otoimmün subklinik hipotiroidizm (Hashimoto tiroiditi), polikistik over sendromu, Kırım Kongo hemorajik ateşi, ani sensorinöral işitme kaybı, prematür ovariyan yetmezlik gibi birçak farklı hastalıkta TDH'nın etyopatogenetik rolü araştırılmıştır (12)(13)(14)(15) . Bu homeostazın immün etyopatogenezde çok önemli rol oynadığı ve TDH'ındaki dengesizliğin oksidatif stres ve doku inflamasyonu aracılığıyla hastalığı tetiklediği düşünülmektedir.…”