A Retrospective Comparison of Ceftriaxone Versus Oxacillin for Osteoarticular Infections Due to Methicillin-Susceptible Staphylococcus aureus

Wieland, Brent W.; Marcantoni, Jodie R.; Bommarito, Kerry M.; Warren, David K.; Marschall, Jonas

doi:10.1093/cid/cir857

Cited by 68 publications

(46 citation statements)

References 22 publications

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“…Thus, Wieland et al . () and Valour et al . () reported treatment failure rates of 12.2% (5/41) and as high as 24.2% (16/66) in native MSSA BJI respectively.…”

Section: Introductionmentioning

confidence: 83%

Adaptive processes ofStaphylococcus aureusisolates during the progression from acute to chronic bone and joint infections in patients

Trouillet‐Assant

Lelièvre

Martins-Simões

et al. 2016

Cellular Microbiology

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Staphylococcus aureus bone and joint infection (BJI) is associated with significant rates of chronicity and relapse. In this study, we investigated how S. aureus is able to adapt to the human environment by comparing isolates from single patients with persisting or relapsing BJIs that were recovered during the initial and recurrent BJI episodes. In vitro and in vivo assays and whole-genome sequencing analyses revealed that the recurrent isolates induced a reduced inflammatory response, formed more biofilms, persisted longer in the intracellular compartments of host bone cells, were less cytotoxic and induced less mortality in a mouse infection model compared with the initial isolates despite the lack of significant changes at the genomic level. These findings suggest that S. aureus BJI chronicization is associated with an in vivo bacterial phenotypical adaptation that leads to decreased virulence and host immune escape, which is linked to increased intraosteoblastic persistence and biofilm formation.

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“…Thus, Wieland et al . () and Valour et al . () reported treatment failure rates of 12.2% (5/41) and as high as 24.2% (16/66) in native MSSA BJI respectively.…”

Section: Introductionmentioning

confidence: 83%

Adaptive processes ofStaphylococcus aureusisolates during the progression from acute to chronic bone and joint infections in patients

Trouillet‐Assant

Lelièvre

Martins-Simões

et al. 2016

Cellular Microbiology

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“…On the other hand, the semisynthetic penicillins may be replaced altogether for patients who cannot be routinely monitored. Accumulating evidence suggests that cefazolin may be a better-tolerated alternative to both nafcillin and oxacillin (18,19,26,27). These findings will need to be balanced with practical considerations like cost and administration of the agents.…”

Section: Discussionmentioning

confidence: 99%

Adverse Events Lead to Drug Discontinuation More Commonly among Patients Who Receive Nafcillin than among Those Who Receive Oxacillin

Viehman

Oleksiuk

Sheridan

et al. 2016

Antimicrob Agents Chemother

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b Nafcillin and oxacillin are used interchangeably in clinical practice, yet few studies have evaluated the safety of these two agents. Our objective was to compare the differential tolerabilities of nafcillin and oxacillin among hospitalized patients. We conducted a retrospective cohort study of all patients who received 12 g/day of nafcillin or oxacillin for at least 24 h. Two hundred twentyfour patients were included. Baseline characteristics and comorbidities were similar among patients receiving nafcillin (n ‫؍‬ 160) and those receiving oxacillin (n ‫؍‬ 64). Hypokalemia, defined as a potassium level of <3.3 mmol/liter or <2.9 mmol/liter or as a >0.5-mmol/liter decrease from the baseline level, occurred more frequently among patients who received nafcillin (51%, 20%, and 56%, respectively) than among those who received oxacillin (17%, 3%, and 34%, respectively; P < 0.0001, P ‫؍‬ 0.0008, and P ‫؍‬ 0.005, respectively). By multivariate logistic regression analysis, receipt of nafcillin was an independent predictor of severe hypokalemia (odds ratio [OR] ‫؍‬ 6.74; 95% confidence interval [CI], 1.46 to 31.2; P ‫؍‬ 0.02). Rates of hepatotoxicity did not differ between groups; however, acute kidney injury occurred more commonly with nafcillin than with oxacillin (18% versus 6%; P ‫؍‬ 0.03). Overall, 18% of patients who received nafcillin discontinued therapy prematurely due to adverse events, compared to 2% of patients who received oxacillin (P ‫؍‬ 0.0004). Nafcillin treatment is associated with higher rates of adverse events and treatment discontinuation than oxacillin among hospitalized adult patients. These findings have important implications for patients in both inpatient and outpatient settings, particularly patients who require long-term therapy and cannot be monitored routinely. Future randomized controlled studies evaluating the efficacy, costs, and tolerability of nafcillin versus oxacillin are warranted.

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“…Although comparative data are lacking for PJIs, studies on the effectiveness of cefazolin for MSSA bacteraemias indicated that it is similar to oxacillin and better than vancomycin [13]. Ceftriaxone, dosed once daily, has recently been favourably compared with oxacillin for bone and joint infections [14] but is not frequently used among EIN members. Treatment for MRSA appears to be much more uniform, with 90% of providers choosing vancomycin as their first-line treatment option.…”

Section: Discussionmentioning

confidence: 99%

Current management of prosthetic joint infections in adults: results of an Emerging Infections Network survey

Marschall

Lane

Beekmann

et al. 2013

International Journal of Antimicrobial Agents

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There is a dearth of guidance on the management of prosthetic joint infections (PJIs), in particular because of the lack of high-quality evidence for optimal antibiotics. Thus, we designed a nine-question survey of current practices and preferences among members of the Emerging Infections Network, a CDC-sponsored network of infectious diseases physicians, which was distributed in May 2012. In total, 556 (47.2%) of 1178 network members responded. As first-line antibiotic choice for MSSA PJI, 59% of responders indicated oxacillin/nafcillin, 33% cefazolin and 7% ceftriaxone; the commonest alternative was cefazolin (46%). For MRSA PJI, 90% preferred vancomycin, 7% daptomycin and 0.8% ceftaroline; the commonest alternative was daptomycin (65%). Antibiotic selection for coagulase-negative staphylococci varied depending on meticillin susceptibility. For staphylococcal PJIs with retained hardware, most providers would add rifampicin. Propionibacterium is usually treated with vancomycin (40%), penicillin (23%) or ceftriaxone (17%). Most responders thought 10–19% of all PJIs were culture-negative. Culture-negative PJIs of the lower extremities are usually treated with a vancomycin/fluoroquinolone combination, and culture-negative shoulder PJIs with vancomycin/ceftriaxone. The most cited criteria for selecting antibiotics were ease of administration and the safety profile. A treatment duration of 6–8 weeks is preferred (by 77% of responders) and is mostly guided by clinical response and inflammatory markers. Ninety-nine percent of responders recommend oral antibiotic suppression (for varying durations) in patients with retained hardware. In conclusion, there is considerable variation in treatment of PJIs both with identified pathogens and those with negative cultures. Future studies should aim to identify optimum treatment strategies.

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A Retrospective Comparison of Ceftriaxone Versus Oxacillin for Osteoarticular Infections Due to Methicillin-Susceptible Staphylococcus aureus

Cited by 68 publications

References 22 publications

Adaptive processes ofStaphylococcus aureusisolates during the progression from acute to chronic bone and joint infections in patients

Adaptive processes ofStaphylococcus aureusisolates during the progression from acute to chronic bone and joint infections in patients

Adverse Events Lead to Drug Discontinuation More Commonly among Patients Who Receive Nafcillin than among Those Who Receive Oxacillin

Current management of prosthetic joint infections in adults: results of an Emerging Infections Network survey

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