A retrospective comparison between influenza and COVID-19-associated ARDS in a Croatian tertiary care center

Gjurašin, Branimir; Santini, Marija; Krajinović, Vladimir; Papić, Neven; Atelj, Anita; Kotarski, Viktor; Krznarić, Juraj; Vargović, Martina; Kutleša, Marko

doi:10.1007/s00508-020-01759-x

Cited by 12 publications

(16 citation statements)

References 13 publications

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“…Three prospective investigations, 82 retrospective observational analyses and 49 case reports/series of COVID-19 patients on ECMO for a total 134 studies (references to the 134 studies in Supplemental Appendix 1), were selected for the systematic review and metaanalysis of single proportions or single means, and six [23][24][25][26][27][28] of them were eligible for the comparative meta-analysis of COVID-19 ECMO patients vs influenza ECMO patients.…”

Section: Resultsmentioning

confidence: 99%

ECMO in COVID-19 Patients: A Systematic Review and Meta-analysis

Bertini

Guarracino

Falcone

et al. 2022

Journal of Cardiothoracic and Vascular Anesthesia

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Section: Resultsmentioning

confidence: 99%

ECMO in COVID-19 Patients: A Systematic Review and Meta-analysis

Bertini

Guarracino

Falcone

et al. 2022

Journal of Cardiothoracic and Vascular Anesthesia

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“…Healthcare professionals, researchers and the lay-public have compared COVID-19 and influenza characteristics [ 11 – 13 , 27 ]. In influenza, studies have found a positive relationship between viral load and disease severity [ 28 – 31 ] but there is conflicting data regarding this relationship in COVID-19 [ 2 , 3 , 5 – 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Physicians and researchers have compared COVID-19 to influenza [ 11 – 13 ] possibly because of the general public's better understanding of the flu. In addition, there is similarity in structure between coronavirus and influenza [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Viral load and disease severity in COVID-19

et al. 2021

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The relationship between COVID-19 severity and viral load is unknown. Our objective was to assess the association between viral load and disease severity in COVID-19. In this single center observational study of adults with laboratory confirmed SARS-CoV-2, the first positive in-hospital nasopharyngeal swab was used to calculate the log10 copies/ml [log10 copy number (CN)] of SARS-CoV-2. Four categories based on level of care and modified sequential organ failure assessment score (mSOFA) at time of swab were determined. Median log10CN was compared between different levels of care and mSOFA quartiles. Median log10CN was compared in patients who did and did not receive influenza vaccine, and the correlation between log10CN and D-dimer was examined. We found that of 396 patients, 54.3% were male, and 25% had no major comorbidity. Hospital mortality was 15.7%. Median mSOFA was 2 (IQR 0–3). Median log10CN was 5.5 (IQR 3.3–8.0). Median log10CN was highest in non-intubated ICU patients [6.4 (IQR 4.4–8.1)] and lowest in intubated ICU patients [3.6 (IQR 2.6–6.9)] ( p value < 0.01). In adjusted analyses, this difference remained significant [mean difference 1.16 (95% CI 0.18–2.14)]. There was no significant difference in log10CN between other groups in the remaining pairwise comparisons. There was no association between median log10CN and mSOFA in either unadjusted or adjusted analyses or between median log10CN in patients with and without influenza immunization. There was no correlation between log10CN and D-dimer. We conclude, in our cohort, we did not find a clear association between viral load and disease severity in COVID-19 patients. Though viral load was higher in non-intubated ICU patients than in intubated ICU patients there were no other significant differences in viral load by disease severity. Supplementary Information The online version contains supplementary material available at 10.1007/s11739-021-02786-w.

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“…Unfortunately, we have limited published data from Central-Eastern European ICUs [19][20][21][22] to compare our data to, but the current results on mortality match with those published on the national and international websites, suggesting that mortality of COVID-19 patients in the six countries included in the current analysis was somewhat higher than in our Western European counterparts [6].…”

Section: Mortalitymentioning

confidence: 62%

Results of the SepsEast Registry to define the Characteristics in Coronavirus Disease in Central-Eastern Europe between March 2020-February 2021: an international, multicentre retrospective study of the SEARCH-COVID-19 Study Group

Beneš

Jankowski

Szułdrzyński

et al. 2022

Preprint

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Background: The coronavirus disease (COVID-19) pandemic caused unprecedented research activity all around the world but publications from Central-Eastern European countries remain scarce. Therefore, our aim was to characterise the features of the pandemic in the intensive care units (ICUs) among members of the SepsEast (Central-Eastern European Sepsis Forum) initiative.Methods: We conducted a retrospective, international, multicentre study between March 2020-February 2021. All adult patients admitted to the ICU with pneumonia caused by COVID-19 were enrolled. Data on baseline and treatment characteristics, organ support and mortality were collected. Results: Eleven centres from six countries provided data from 2139 patients. Patient characteristics were; median 68, [IQR 60-75] years of age; males: 67%; body mass index: 30.1 [27.0-34.7]; and 88% comorbidities. Overall mortality was 55%, which increased from 2020 to 2021 (p=0.004). The major causes of death were respiratory (37%), cardiovascular (26%) and sepsis with multiorgan failure (21%). 1061 patients received invasive mechanical ventilation (mortality: 66%) without extracorporeal membrane oxygenation (n=54). The rest of the patients received non-invasive ventilation (n=129), high flow nasal oxygen (n=317), conventional oxygen therapy (n=122), as the highest level of ventilatory support, with mortality of 50%, 39% and 22%, respectively. Conclusions: This is the largest COVID-19 dataset from Central-Eastern European ICUs to date. The high mortality observed especially in those receiving invasive mechanical ventilation renders the need of establishing national-international ICU registries and audits in the region that could provide high quality, transparent data, not only during the pandemic, but also on a regular basis.

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A retrospective comparison between influenza and COVID-19-associated ARDS in a Croatian tertiary care center

Cited by 12 publications

References 13 publications

ECMO in COVID-19 Patients: A Systematic Review and Meta-analysis

ECMO in COVID-19 Patients: A Systematic Review and Meta-analysis

Viral load and disease severity in COVID-19

Results of the SepsEast Registry to define the Characteristics in Coronavirus Disease in Central-Eastern Europe between March 2020-February 2021: an international, multicentre retrospective study of the SEARCH-COVID-19 Study Group

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