A retrospective, cohort study of the prevalence and risk factors of oral burning in patients with dry mouth

Rouleau, Tanya; Shychuk, Andrew; Kayastha, Jimmy; Lockhart, Peter B.; Nussbaum, Marcy; Brennan, Michael T.

doi:10.1016/j.tripleo.2011.01.042

Cited by 9 publications

(5 citation statements)

References 20 publications

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“…The prevalence of BMS is thought to be less than 10% in the population . In the present study, almost 20% of the chronic LT recipients but only 5% of the acute LT recipients complained about a burning sensation in the oral mucosa, mainly on the side of the tongue.…”

Section: Discussioncontrasting

confidence: 46%

Self-Reported Oral Symptoms and Signs in Liver Transplant Recipients and a Control Population

et al. 2013

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Recipients of liver transplantation (LT) receive lifelong immunosuppression, which causes side effects. We investigated selfreported oral symptoms and associated risk factors with the following hypothesis: symptoms and signs would differ between LT recipients of different etiology groups and also between LT recipients and a control population. Eighty-four LT recipients (64 with chronic liver disease and 20 with acute liver disease) were recruited for clinical oral and salivary examinations (median follow-up 5 5.7 years). A structured questionnaire was used to record subjective oral symptoms. Matched controls (n 5 252) came from the National Finnish Health 2000 survey. The prevalence of symptoms was compared between the groups, and the risk factors for oral symptoms were analyzed. Xerostomia was prevalent in 48.4% of the chronic LT recipients and in 42.1% of the acute LT recipients. This subjective feeling of dry mouth was only partly linked to objectively measured hyposalivation. The chronic transplant recipients had significantly lower unstimulated salivary flow rates than the acute transplant recipients (0.34 6 0.31 versus 0.61 6 0.49 mL/minute, P 5 0.005). Among the chronic transplant recipients, hyposalivation with unstimulated salivary flow was associated with fewer teeth (17.7 6 8.2 versus 21.9 6 8.4, P 5 0.047) and more dentures (33.3% versus 12.2%, P 5 not significant). The chronic patients reported significantly more dysphagia than their controls (23.4% versus 11.5%, P 5 0.02). Increases in the number of medications increased the symptoms in all groups. In conclusion, dysphagia was significantly more prevalent among the chronic LT recipients versus the controls. The number of medications was a risk factor for dry mouth-related symptoms for both the LT recipients and the controls. The chronic transplant recipients presented with lower salivary flow rates than the acute transplant recipients. Hyposalivation correlated with generally worse oral health among the chronic transplant recipients. These differences between the chronic and acute LT recipients may have been due to differences in their medical conditions due to the different etiologies. Liver Transpl 19:155-163, 2013. V C 2012 AASLD. Received September 3, 2012 accepted November 6, 2012. Liver transplantation (LT) was first performed in Scandinavia at the Helsinki University Central Hospital (HUCH) in Finland already 30 years ago. The 5-year survival rates for LT recipients have improved significantly, with recent rates reaching 85%. Despite fewer rejections and better tolerance, immunosuppressive therapy can still cause side effects, among which infections, cardiovascular disease, posttransplant diabetes, kidney insufficiency, and malignancies are the most serious.

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Section: Discussioncontrasting

confidence: 46%

Self-Reported Oral Symptoms and Signs in Liver Transplant Recipients and a Control Population

et al. 2013

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“…The most significant clinical factor associated with the OHRQoL in patients with BMS was the intensity of taste disturbance or xerostomia. Taste disturbance or xerostomia which is a common symptom among patients with BMS [19][20][21][22] has been reported to be associated with QoL and OHRQoL, respectively. 11,18,[23][24][25][26] In our study, 41 (71.9%) patients reported taste disturbances.…”

Section: Discussionmentioning

confidence: 99%

Oral health‐related quality of life and associated factors in patients with burning mouth syndrome

Choi

Kim

Kho

2020

J of Oral Rehabilitation

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Objective The purpose of this study was to assess oral health‐related quality of life (OHRQoL) in patients with burning mouth syndrome (BMS) and to identify clinical factors associated with OHRQoL. Methods Fifty‐seven patients with BMS (56.4 ± 10.7 years) participated in the study. Patients underwent oral examination, laboratory tests, psychological evaluation, measurement of salivary flow rates and evaluation of clinical characteristics using a BMS questionnaire. The OHRQoL of patients was assessed using the Oral Health Impact Profile‐14 (OHIP‐14). Results The OHIP‐14 score for patients with BMS was 38.6 ± 12.8. Patients had higher scores for the psychological discomfort and physical pain dimensions of the OHIP‐14. The intensity of taste disturbance or xerostomia symptoms (β = 0.464, P < .001), worry about symptoms (β = 0.307, P = .020), and results of psychological evaluation (β = 0.311, P = .026) were significantly associated with OHIP‐14 score. Multiple linear regression showed that the intensity of taste disturbance or xerostomia symptoms was significantly associated with decreased OHRQoL (β = 0.637, P = .026). Conclusions This study suggests that severity of taste disturbance or xerostomia is an important factor that influences OHRQoL in patients with BMS.

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“…When calculating the sample size of this study, the prevalence of BMS among subjects with xerostomia was set to be 20% based on previous studies [ 20 , 22 ]. A minimum number of the sample size was determined to be 100 participants with 20 positive cases in order to obtain a sensitivity of 80% with a power of 80% and a confidence of 95% [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

Clinical Utility of Quantitative Parameters of Salivary Gland Scintigraphy for Diagnosing Burning Mouth Syndrome

et al. 2022

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Burning mouth syndrome (BMS) is a chronic disorder characterized by a burning sensation in the oral cavity, often accompanied by xerostomia, with no relevant clinical or laboratory findings. This study aimed to investigate diagnostic values of quantitative parameters of salivary gland scintigraphy for BMS in patients with xerostomia. A total of 164 patients who underwent salivary gland scintigraphy for the workup of xerostomia were retrospectively reviewed. All patients were classified into patient groups with primary BMS, secondary BMS, and non-specific xerostomia. From salivary gland scintigraphy, 22 quantitative parameters were calculated and their diagnostic values were assessed based on the area under the receiver operating characteristic curve (AUC) values. Among salivary gland scintigraphy parameters, uptake speed in the left submandibular gland showed the highest AUC value (0.647) for detecting BMS and pre-stimulatory oral activity showed the highest AUC value (0.710) for detecting primary BMS. A salivary gland scintigraphy scoring system based on these two parameters further enhanced the diagnostic ability, demonstrating AUC values of 0.731 for BMS and 0.782 for primary BMS. These results suggest a potential diagnostic value of the quantitative parameters of salivary gland scintigraphy for detecting BMS in patients with xerostomia.

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A retrospective, cohort study of the prevalence and risk factors of oral burning in patients with dry mouth

Cited by 9 publications

References 20 publications

Self-Reported Oral Symptoms and Signs in Liver Transplant Recipients and a Control Population

Self-Reported Oral Symptoms and Signs in Liver Transplant Recipients and a Control Population

Oral health‐related quality of life and associated factors in patients with burning mouth syndrome

Clinical Utility of Quantitative Parameters of Salivary Gland Scintigraphy for Diagnosing Burning Mouth Syndrome

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