A retrospective analysis of the accuracy of radioactively labeled autologous leukocytes in patients with infected prosthetic joints

Brammen, Lindsay; Palestro, Christopher J.; Holinka, Johannes; Windhager, Reinhard; Sinzinger, H.

doi:10.5603/nmr.2017.0013

Cited by 6 publications

(8 citation statements)

References 41 publications

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“…The tests that showed the highest overall accuracy for PJI based on DOR were serum IL-6, synovial fluid cytology, sonication, and histopathology. Nuclear tests showed low overall accuracy for diagnosing PJI as highlighted in another recent review article [6]. It should be noted, however, that a test with only a high potency for either ruling in a PJI, or ruling out a PJI would result in a low overall accuracy, reflected in the DOR.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of diagnostic tests for prosthetic joint infection: a systematic review

Ahmad

Shaker

Saffarini³

et al. 2016

Knee Surg Sports Traumatol Arthrosc

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Section: Discussionmentioning

confidence: 99%

Accuracy of diagnostic tests for prosthetic joint infection: a systematic review

Ahmad

Shaker

Saffarini³

et al. 2016

Knee Surg Sports Traumatol Arthrosc

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“…For example, this combined imaging modality has been proposed as the best choice for diagnosing periprosthetic knee infections in a recent meta-analysis performed by Verberne and colleagues [39]. Authors obtained an overall specificity and sensitivity equal to 93% and 80%, respectively which was confirmed in another recent review [40].…”

Section: Radiolabelled White Blood Cell Scintigraphy For the Diagnmentioning

confidence: 81%

Immuno-Imaging to Predict Treatment Response in Infection, Inflammation and Oncology

Lauri

Auletta

Anzola

et al. 2019

JCM

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Background: Molecular nuclear medicine plays a pivotal role for diagnosis in a preclinical phase, in genetically susceptible patients, for radio-guided surgery, for disease relapse evaluation, and for therapy decision-making and follow-up. This is possible thanks to the development of new radiopharmaceuticals to target specific biomarkers of infection, inflammation and tumour immunology. Methods: In this review, we describe the use of specific radiopharmaceuticals for infectious and inflammatory diseases with the aim of fast and accurate diagnosis and treatment follow-up. Furthermore, we focus on specific oncological indications with an emphasis on tumour immunology and visualizing the tumour environment. Results: Molecular nuclear medicine imaging techniques get a foothold in the diagnosis of a variety of infectious and inflammatory diseases, such as bacterial and fungal infections, rheumatoid arthritis, and large vessel vasculitis, but also for treatment response in cancer immunotherapy. Conclusion: Several specific radiopharmaceuticals can be used to improve diagnosis and staging, but also for therapy decision-making and follow-up in infectious, inflammatory and oncological diseases where immune cells are involved. The identification of these cell subpopulations by nuclear medicine techniques would provide personalized medicine for these patients, avoiding side effects and improving therapeutic approaches.

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“…Different results in reported studies can be explained by the use of different acquisition protocols and interpretations. The low sensitivity reported by Brammen et al could be rated to 100% after reviewing imaging by one of the leading nuclear medicine specialists, demonstrating the importance of standardized image interpretation by experts [60]. The latest reviews and meta-analysis obtained from papers with consistent combined techniques show a pooled specificity of 92% (95% CI, 84-97%) [51] and diagnostic accuracy ranging from 83% to 98% for both hip and knee prosthesis infections [49].…”

Section: Discussionmentioning

confidence: 99%

“…The study by Palestro et al from 1990 demonstrated high diagnostic accuracy on combined 111 In-labeled leucocyte and bone marrow imaging in PJI; the results demonstrated a sensitivity, a specificity, and an accuracy of 100%, 97%, and 98%, respectively [37]. Some later published papers reported slightly different diagnostic accuracy for combining techniques, ranging from 86% to 98% [18]; the sensitivity, specificity, and accuracy reported by Love C et al were 100%, 91%, and 95%, respectively [57,58]; those reported by El Esper et al were 80%, 94%, and 91%, respectively [59]; and those reported by Brammen L et al were 60%, 97%, and 90%, respectively [60]. Different results in reported studies can be explained by the use of different acquisition protocols and interpretations.…”

Section: Discussionmentioning

confidence: 99%

The Role of Nuclear Medicine Imaging with 18F-FDG PET/CT, Combined 111In-WBC/99mTc-Nanocoll, and 99mTc-HDP SPECT/CT in the Evaluation of Patients with Chronic Problems after TKA or THA in a Prospective Study

et al. 2022

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Background: The aim of this prospective study was to assess the diagnostic value of nuclear imaging with 18F-FDG PET/CT (FDG PET/CT), combined 111In-WBC/99mTc-Nanocoll, and 99mTc-HDP SPECT/CT (dual-isotope WBC/bone marrow scan) for patients with chronic problems related to knee or hip prostheses (TKA or THA) scheduled by a structured multidisciplinary algorithm. Materials and Methods: Fifty-five patients underwent imaging with 99mTc–HDP SPECT/CT (bone scan), dual-isotope WBC/bone marrow scan, and FDG PET/CT. The final diagnosis of prosthetic joint infection (PJI) and/or loosening was based on the intraoperative findings and microbiological culture results and the clinical follow-up. Results: The diagnostic performance of dual-isotope WBC/bone marrow SPECT/CT for PJI showed a sensitivity of 100% (CI 0.74–1.00), a specificity of 97% (CI 0.82–1.00), and an accuracy of 98% (CI 0.88–1.00); for PET/CT, the sensitivity, specificity, and accuracy were 100% (CI 0.74–1.00), 71% (CI 0.56–0.90), and 79% (CI 0.68–0.93), respectively. Conclusions: In a standardized prospectively scheduled patient group, the results showed highly specific performance of combined dual-isotope WBC/bone marrow SPECT/CT in confirming chronic PJI. FDG PET/CT has an appropriate accuracy, but the utility of its use in the clinical diagnostic algorithm of suspected PJI needs further evidence.

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A retrospective analysis of the accuracy of radioactively labeled autologous leukocytes in patients with infected prosthetic joints

Abstract: BACKGROUND: Labeled leukocyte scintigraphy (LS) is considered a valuable tool in preoperative diagnosis of prosthetic joint infections (PJI). The aim of this study was to determine the accuracy of LS combined with bone marrow scintigraphy (BMS),

Cited by 6 publications

References 41 publications

Accuracy of diagnostic tests for prosthetic joint infection: a systematic review

Accuracy of diagnostic tests for prosthetic joint infection: a systematic review

Immuno-Imaging to Predict Treatment Response in Infection, Inflammation and Oncology

The Role of Nuclear Medicine Imaging with 18F-FDG PET/CT, Combined 111In-WBC/99mTc-Nanocoll, and 99mTc-HDP SPECT/CT in the Evaluation of Patients with Chronic Problems after TKA or THA in a Prospective Study

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