A retrospective analysis of schistosomiasis related literature from 2011-2020: Focusing on the next decade

Xue, Qingkai; Deng, Yao; Liu, Yiyun; Wang, Yuyan; Hu, Wenjun; Huang, You‐Gui; Yang, Kun

doi:10.1016/j.actatropica.2022.106750

Cited by 7 publications

(5 citation statements)

References 42 publications

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“…Response efficacy referred to the understanding of disease prevention and information concerning control. In most of these studies, the knowledge, attitudes, and practices (KAP) questionnaire on schistosomiasis control also included cause of infection, symptoms, prevention, and risky behaviors (23)(24)(25). Furthermore, not all the four substructures were closely associated with knowledge, which was associated with behavior intention.…”

Section: Discussionmentioning

confidence: 99%

Protection motivation theory in predicting intentional behaviors regards schistosomiasis: a WeChat-based qualitative study

Wang,

Li,

Zhang

et al. 2024

Front. Public Health

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BackgroundModifications of behavior can help reduce the risk of transmission by disrupting the parasite life cycle. Behavior intension is a necessary intermediate step in behavior change. This study aimed to explore protection motivation theory (PMT) in predicting likelihood of engagement in protective behavior against infection with Schistosoma.MethodsIn China, a questionnaire for data collection was sent to users who followed the WeChat public account from June 2 to 6, 2023. Factors affecting intentional behavior of participants were analyzed using stepwise regression analysis and structural equation modeling.ResultsA total of 2,243 valid questionnaires were collected, with a mean age of 30 ± 8.4 years. Approximately 1,395 (62.2%) participants reported that they had been exposed to wild waters in daily work and life. About 51.0 and 50.7% of respondents reported never having been exposed to wild water in the last 3 and 6 months, respectively. Results indicated that prior knowledge of schistosomiasis was associated with the 7 PMT subconstructs, which then influenced future preventative behaviors.ConclusionBehavior intentionis a complicated and indispensable part of behavior change that is influenced by professional knowledge, socio-economic status, and personal characteristics. The effective dissemination of knowledge regards schistosomiasis should be strengthened to emphasize the effectiveness of protective measures against infection and severe disease.

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Section: Discussionmentioning

confidence: 99%

Protection motivation theory in predicting intentional behaviors regards schistosomiasis: a WeChat-based qualitative study

Wang,

Li,

Zhang

et al. 2024

Front. Public Health

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“…Schistosomiasis is a parasitic disease that is widely prevalent in tropical and subtropical regions, and it poses a serious health risk to humans [ 1 , 2 ]. The World Health Organization has estimated that approximately 779 million people are at risk of schistosomiasis infection worldwide, and more than 250 million people are infected with schistosomiasis [ 3 , 4 ]. The primary schistosomes affecting humans include Schistosoma mansoni , Schistosoma japonicum ( S. japonicum ), and Schistosoma haematobium , with S. japonicum being particularly prevalent in China [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Dysregulated Glucuronidation of Bilirubin Exacerbates Liver Inflammation and Fibrosis in Schistosomiasis Japonica through the NF-κB Signaling Pathway

Xue,

Wang,

Liu

et al. 2024

Pathogens

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Hepatic fibrosis is an important pathological manifestation of chronic schistosome infection. Patients with advanced schistosomiasis show varying degrees of abnormalities in liver fibrosis indicators and bilirubin metabolism. However, the relationship between hepatic fibrosis in schistosomiasis and dysregulated bilirubin metabolism remains unclear. In this study, we observed a positive correlation between total bilirubin levels and the levels of ALT, AST, LN, and CIV in patients with advanced schistosomiasis. Additionally, we established mouse models at different time points following S. japonicum infection. As the infection time increased, liver fibrosis escalated, while liver UGT1A1 consistently exhibited a low expression, indicating impaired glucuronidation of bilirubin metabolism in mice. In vitro experiments suggested that SEA may be a key inhibitor of hepatic UGT1A1 expression after schistosome infection. Furthermore, a high concentration of bilirubin activated the NF-κB signaling pathway in L-O2 cells in vitro. These findings suggested that the dysregulated glucuronidation of bilirubin caused by S. japonicum infection may play a significant role in schistosomiasis liver fibrosis through the NF-κB signaling pathway.

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“…Schistosomiasis, a neglected tropical disease (NTD), is one of the most important prevalent human and animal parasitoses in tropical and subtropical region worldwide [ 1 ]. Schistosomiasis is a debilitating chronic disease with great socioeconomic and public health impact affecting the poor rural populations who lack access to sanitation, and safe water supply [ 2 ]. In this regards, snail control plays a central role in schistosomiasis [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Achyranthes aspera leaf extract and acute toxicity study on fingerlings of Nile tilapia, Oreochromis niloticus

Mandefro,

Fereja,

Fremichael

et al. 2024

Biochemistry and Biophysics Reports

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A retrospective analysis of schistosomiasis related literature from 2011-2020: Focusing on the next decade

Cited by 7 publications

References 42 publications

Protection motivation theory in predicting intentional behaviors regards schistosomiasis: a WeChat-based qualitative study

Protection motivation theory in predicting intentional behaviors regards schistosomiasis: a WeChat-based qualitative study

Dysregulated Glucuronidation of Bilirubin Exacerbates Liver Inflammation and Fibrosis in Schistosomiasis Japonica through the NF-κB Signaling Pathway

Analysis of Achyranthes aspera leaf extract and acute toxicity study on fingerlings of Nile tilapia, Oreochromis niloticus

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