A retrospective analysis of chemotherapy for gastric cancer in later-stage elderly patients

Ina, Kenji; Ina, Hiroko; Yoneda, Masahiko; Kabeya, Megumi; Yuasa, Syuu; Tomomatsu, Yuko; Furuta, Ryuichi

doi:10.3143/geriatrics.55.244

Cited by 1 publication

(1 citation statement)

References 19 publications

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“…More than half of all cases of gastric cancer are in the over 70 years age group, although this group of patients tends to be underestimated in prospective studies in which chemotherapy in MGC is evaluated due to the comorbidities that are common in elderly cancer patients (i.e., diabetes, hypertension, chronic obstructive pulmonary disease, and coronary artery disease) and physiological losses secondary to the ageing process (i.e., impaired kidney and liver function) 8 . Accordingly, in clinical practice, patients with a low performance status receive the best supportive treatment, while patients with a intermediate and good performance status receive monotherapies tolerated better, compared to combined treatments or modified low doses of the combined treatment rather than optimal doses.…”

Section: Introductionmentioning

confidence: 99%

Yaşlı metastatik mide kanserli hastalarda tek başına oral kapesitabin ile platin kombinasyonlarının karşılaştırılması

2019

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AbsractObjective: Gastric cancer is responsible for a considerable proportion of all cancer-related deaths. Elderly cancer patients are often ignored in prospective studies in which the efficacy of chemotherapy is evaluated, although more than half of all gastric cancer cases are over the age of 70 years. The present study aims to evaluate the efficacy and feasibility of capecitabine-based chemotherapies in geriatric patients with gastric cancer.Method: A total of 81 patients over the age of 65 years who received chemotherapy for metastatic gastric cancer at two oncology centers between 2012 and 2017 were included in the study. The medical records of the patients were evaluated retrospectively, and the patients and their performance status were evaluated using the American Joint Committee on Cancer staging system and the World Health Organisation scale, respectively.Results: The mean age was 74 years. The male gender and the adenocarcinoma histological type were seen in higher rates. Most of the patients underwent capecitabine-cisplatin chemotherapy, and the mean follow-up was 42 months. The median overall survival of the groups of patients receiving capecitabine-cisplatin, capecitabine-oxaliplatin and capecitabine was 8 months, 10.7 months and 8.9 months, respectively, indicating no statistically significant differences between the groups (p=0.467). The median overall survival of all patients was found to be 8.7 months. The progression-free survival between the different chemotherapy subgroups was not statistically significant (p=0.59). The most common side effect was found to be anemia. Grade 3-4 adverse effects were similar between the arms of the study (p=0.725). A statistically significant increase was found in the mortality risk with an increased number of metastatic sites in a multivariate analysis (p=0.001). No correlation was found between the chemotherapy protocols and mortality risk (p=0.472). Adverse effects such as stomatitis, nausea/vomiting, neuropathy, neutropenic fever and nephrotoxicity, independent of chemotherapy, were statistically and significantly associated with the mortality risk (p=0.045, p=0.047, p=0.036, p=0.02 and p=0.049, respectively).

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Section: Introductionmentioning

confidence: 99%

Yaşlı metastatik mide kanserli hastalarda tek başına oral kapesitabin ile platin kombinasyonlarının karşılaştırılması

2019

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A retrospective analysis of chemotherapy for gastric cancer in later-stage elderly patients

Abstract: This comprehensive geriatric assessment was useful for predicting the longevity of patients with stage 4 gastric cancer ≥ 75 years of age.

Cited by 1 publication

References 19 publications

Yaşlı metastatik mide kanserli hastalarda tek başına oral kapesitabin ile platin kombinasyonlarının karşılaştırılması

Yaşlı metastatik mide kanserli hastalarda tek başına oral kapesitabin ile platin kombinasyonlarının karşılaştırılması

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