A retrospective analysis of catheter-based sources in intravascular brachytherapy

DeCunha, Joseph M.; Janicki, Christian; Enger, Shirin A.

doi:10.1016/j.brachy.2017.01.004

Cited by 6 publications

(1 citation statement)

References 23 publications

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“…Vascular stents are used to increase the luminal diameter of the coronary arteries. The use of drugs to coat stents drastically reduces the process of re-stenosis [14,15]. Its expandable metal composition, whether coated with any drug or not, has a structure comprising a metal core of cobalt–chromium alloy or stainless steel and on the outside may have a coating of two polymers, lactic acid-co-glycolic acid (PLGA) or polylactic acid (PLA) that, in turn, can be manipulated to have additional drugs or antibodies integrated [16,17,18].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Antibiofilm Effects of Peptides from Venom of Social Wasp and Scorpion on Multidrug-Resistant Acinetobacter baumannii

Neves

Mortari

Schwartz

et al. 2019

Toxins

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Intravascular stent infection is a rare complication with a high morbidity and high mortality; bacteria from the hospital environment form biofilms and are often multidrug-resistant (MDR). Antimicrobial peptides (AMPs) have been considered as alternatives to bacterial infection treatment. We analyzed the formation of the bacterial biofilm on the vascular stents and also tested the inhibition of this biofilm by AMPs to be used as treatment or coating. Antimicrobial activity and antibiofilm were tested with wasp (Agelaia-MPI, Polybia-MPII, Polydim-I) and scorpion (Con10 and NDBP5.8) AMPs against Acinetobacter baumannii clinical strains. A. baumannii formed a biofilm on the vascular stent. Agelaia-MPI and Polybia-MPII inhibited biofilm formation with bacterial cell wall degradation. Coating biofilms with polyethylene glycol (PEG 400) and Agelaia-MPI reduced 90% of A. baumannii adhesion on stents. The wasp AMPs Agelaia-MPI and Polybia-MPII had better action against MDR A. baumannii adherence and biofilm formation on vascular stents, preventing its formation and treating mature biofilm when compared to the other tested peptides.

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