A retrospective analysis of 111 canine prostatic samples: Histopathological findings and classification

Palmieri, Chiara; Lean, Fabian Z. X.; Akter, Sharmin; Romussi, S.; Grieco, Valeria

doi:10.1016/j.rvsc.2014.11.006

Cited by 52 publications

(64 citation statements)

References 25 publications

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“…The diagnoses were made according to Fonseca- Alves et al (2010) for benign prostatic hyperplasia (BPH) and prostatic intraepithelial neoplasia (PIN), proliferative inflammatory atrophy (PIA). Prostatic carcinomas (PC) were diagnosed according to Palmieri et al (2014).…”

Section: Methodsmentioning

confidence: 99%

“…Comparative oncology studies using dogs are a unique opportunity to evaluate spontaneous tumors in animal models beneficiating both species: humans and dogs. Dogs are the only mammal besides humans in which spontaneous PC develops with higher frequency (Palmieri et al 2014, Fonseca-Alves et al 2017). An important difference between both species is that dogs show higher incidence of androgen independent tumors than humans (Bryan et al 2007).…”

Section: Introductionmentioning

confidence: 99%

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Association between decreased expression of estrogen receptor alpha, androgen receptor and phosphatase and tensin homolog immunoexpression in the canine prostate

et al. 2019

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Canine prostate gland is a hormonal dependent organ and its imbalance of estrogen and androgen receptor expressions are directly associated with the development of different diseases. Due to the lack of information regarding the behavior of the aforementioned receptors in canine prostate cancer (PC), this study aimed to identify estrogen receptor alpha (ERα), androgen receptor (AR), Ki67 and phosphatase and tensin homolog (PTEN) protein expressions in canine PC by immunohistochemistry. We found nuclear expression of ERα and AR in the epithelial cells of normal canine samples and a loss of protein expression in PC samples. Normal samples showed Ki67 expression in a few basal cells and the PC samples showed the highest mean of positive cells (253.1). Canine prostate cancer showed a high proliferative index, which was associated with independence of hormonal actuation. PTEN showed positive nuclear and cytoplasmic expression in normal canine samples and a loss in PC. Loss of ERα, AR and PTEN indicated that canine PC exhibits the same immunohistochemical phenotype as in human patients with PC resistant to hormonal therapy. Therefore, canine PC should be considered as a model to study human PC resistant to hormonal therapy.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between decreased expression of estrogen receptor alpha, androgen receptor and phosphatase and tensin homolog immunoexpression in the canine prostate

et al. 2019

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“…Other similar pathological features of HGPIN between human and canine PCa include basal cell disruption, proliferative index, and microvessel density (20). According to the limited published data, only three research groups have reported their pathological studies of HGPIN in totally 610 dogs with various specimens collected in necropsy, biopsy, and surgical incision (20-24). Taken together, HGPIN was found in 85 out of 610 dogs with an overall mean incidence of 13.9%; 55 out of 151 (33.1%) dogs with prostate carcinoma had synchronous HGPIN (20-24).…”

Section: Canine Spontaneous Pcamentioning

confidence: 99%

“…According to the limited published data, only three research groups have reported their pathological studies of HGPIN in totally 610 dogs with various specimens collected in necropsy, biopsy, and surgical incision (20-24). Taken together, HGPIN was found in 85 out of 610 dogs with an overall mean incidence of 13.9%; 55 out of 151 (33.1%) dogs with prostate carcinoma had synchronous HGPIN (20-24). However, the relationship of HGPIN and the risk of subsequent development of PCa in dogs remains unknown.…”

Section: Canine Spontaneous Pcamentioning

confidence: 99%

Canine prostate models in preclinical studies of minimally invasive interventions: part I, canine prostate anatomy and prostate cancer models

Sun¹,

Báez-Díaz²,

Sánchez‐Margallo³

2017

Transl. Androl. Urol.

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The high prevalence of prostate cancer (PCa) in elderly men and technical advances in early detection of localized PCa have led to continued efforts to develop new therapeutic options of minimally invasive nature in current urologic oncology community. Increasing newly emerging therapies are undergoing preclinical tests on the technical feasibility, efficacy and safety in animal experiments. The dog is an ideal large animal because of its similar anatomy to human and the capability allowing the use of the same medical devices applied in future clinical trials. Awareness of the local anatomy, microvascular structure, and histological features of the prostate in dogs is essential to experimental design and performance of the tested procedures and techniques. Although dogs with spontaneous PCa may be used in preclinical investigation, the low incidence and pathological features limit its utility. Alternatively, canine orthotopic PCa models have a great potential in preclinical research for this purpose. The goal of this review is to provide detailed anatomic and histological information of the canine prostate, outline the pathological and clinical characteristics of spontaneous PCa in dogs and discuss the current status of canine orthotopic PCa models.

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“…Interestingly, these data correspond with those recorded before in human prostate sorted cell-derived organoids [148], emphasizing the importance of this model in analyzing the cell of origin of PC in human. Compared with human, dogs are known to spontaneously develop PC [155] and have some similarities in the pathogenesis of the disease [156]. Therefore, dog PC may serve as a useful model for the diagnosis and treatment of PC in human.…”

Section: Pc Organoids To Study Cell Of Origin Of Pcmentioning

confidence: 99%

Development of Prostate Cancer Organoid Culture Models in Basic Medicine and Translational Research

Elbadawy

Abugomaa

Yamawaki

et al. 2020

Cancers

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Prostate cancer (PC) is the most prevalent cancer in men and the second main cause of cancer-related death in Western society. The lack of proper PC models that recapitulate the molecular and genomic landscape of clinical disease has hampered progress toward translational research to understand the disease initiation, progression, and therapeutic responses in each patient. Although several models have been developed, they hardly emulated the complicated PC microenvironment. Precision medicine is an emerging approach predicting appropriate therapies for individual cancer patients by means of various analyses of individual genomic profiling and targeting specific cancer pathways. In PC, precision medicine also has the potential to impose changes in clinical practices. Here, we describe the various PC models with special focus on PC organoids and their values in basic medicine, personalized therapy, and translational researches in vitro and in vivo, which could help to achieve the full transformative power of cancer precision medicine.

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A retrospective analysis of 111 canine prostatic samples: Histopathological findings and classification

Cited by 52 publications

References 25 publications

Association between decreased expression of estrogen receptor alpha, androgen receptor and phosphatase and tensin homolog immunoexpression in the canine prostate

Association between decreased expression of estrogen receptor alpha, androgen receptor and phosphatase and tensin homolog immunoexpression in the canine prostate

Canine prostate models in preclinical studies of minimally invasive interventions: part I, canine prostate anatomy and prostate cancer models

Development of Prostate Cancer Organoid Culture Models in Basic Medicine and Translational Research

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