A retroperitoneal neuroendocrine tumor in ectopic pancreatic tissue

Okasha, HusseinHassan; Al-Bassiouni, Fahim; El-Ela, MonirAbo; Al-Gemeie, EmadHamza; Ezzat, Reem

doi:10.4103/2303-9027.117676

Cited by 11 publications

(6 citation statements)

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“…Ectopic tissue is usually discovered incidentally or may become symptomatic b e c a u s e o f o b s t r u c t i o n caused by enlargement due to inflammation, bleeding or malignant transformation [3,6,7]. A malignant tumor arising in the heterotopic pancreas is an extremely rare event described in 28 cases in the gastroduodenal region and in a few cases in other locations [17][18][19][20], including 2 in the esophagus [5,7]. Premalignant lesions, namely in the form of pancreatic intraepithelial neoplasia (PanIN), are found not only adjacent to malignant tumors, but also in patients without invasive carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Premalignant and Malignant Lesions of the Heterotopic Pancreas in the Esophagus: a Case Report and Review of the Literature

Ulrych

Frýba

Skálová

et al. 2015

JGLD

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Heterotopic pancreas is a congenital pathology of the gastrointestinal tract, particularly rare in the esophagus. Both symptomatology and findings during preoperative examinations are non-specific and therefore do not often lead to an accurate diagnosis, which is usually revealed only by histopathological assessment of a resected specimen. We report an unusual case of a patient suffering from severe dysphagia caused by heterotopic pancreas in the distal esophagus with chronic inflammation and foci of premalignant changes. This article also reviews 14 adult cases of heterotopic pancreas in the esophagus previously reported in the literature, with the aim of determining the clinical features of this disease and possible complications including rare premalignant lesions and malignant transformation. Especially with regard to those complications, we suggest that both symptomatic and incidentally found asymptomatic lesions should be resected.

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Section: Introductionmentioning

confidence: 99%

Premalignant and Malignant Lesions of the Heterotopic Pancreas in the Esophagus: a Case Report and Review of the Literature

Ulrych

Frýba

Skálová

et al. 2015

JGLD

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“…9 In addition, there have been 3 previously reported NETs described in association with pancreatic heterotopia. 10 -12…”

Section: Discussionmentioning

confidence: 99%

“…4 -9 However, neuroendocrine neoplasms in association with pancreatic heterotopia are extremely rare and not well described with only 3 prior published cases of neuroendocrine tumor (NET) arising from heterotopic pancreas. 10 -12 This is the first described case of a NET in association with a jejunal submucosal pancreatic heterotopia.…”

Section: Introductionmentioning

confidence: 88%

A Rare Case of Well-Differentiated Neuroendocrine Tumor Arising From a Jejunal Pancreatic Heterotopia

Sappenfield

Byrnes

2020

Int J Surg Pathol

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Pancreatic heterotopia is a well-described entity occurring at multiple abdominal sites, most commonly the stomach and small intestine. They can develop similar disease processes as the pancreas ranging from acute pancreatitis, cyst formation, or neoplasms, most commonly ductal adenocarcinoma. Neuroendocrine tumors (NETs) arising in pancreatic heterotopias are exceedingly rare with only 3 prior published cases. In this article, we describe the first reported case of a NET arising in a jejunal pancreatic heterotopia in a 59-year-old woman presenting with abdominal pain and diarrhea. The submucosal tumor was composed of a well-differentiated NET (World Health Organization grade 1) directly intermixed with a heterotopic pancreas consisting of acinar cells, islet cells, and ducts. This case illustrates that NETs can occur in association with pancreatic heterotopias at any site. Also, the importance for pathologists to recognize that pancreatic heterotopias can give rise to a variety of neoplasms and is not limited to ductal adenocarcinoma.

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“…Extremely rare cases of PENs developed from HP have been described [8,17,18], therefore there exists the risk to misinterpret the normal endocrine tissue in HP as a possible endocrine tumor [19]. Endocrine microadenomas in the normally placed pancreas are rare lesions, mostly discovered incidentally, usually circumscribed, measuring 1-2mm.…”

Section: Discussionmentioning

confidence: 99%

Intestinal Heterotopic Pancreas Involved by Simultaneous PanIN-2 Lesion and Endocrine Microadenoma: a Unique Case

Tăban

Suciu

Lăzureanu

et al. 2017

JGLD

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We hereby present the case of a 58-year-old male who underwent a total gastrectomy for gastric neoplasm. During the surgery, a tumor mass in the jejunum was identified, considered as metastasis, and resected. The histopathological examination of the jejunal lesion showed ectopic pancreas. In this area, two pathological distinct lesions were identified, one histologically compatible with pancreatic intraepithelial neoplasia (PanIN) type 2 lesion and the other with morphologic criteria for endocrine microadenoma. To our knowledge, this is the first case that evidences the presence of a concomitant premalignant exocrine lesion and benign endocrine lesion in a heterotopic pancreas.

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A retroperitoneal neuroendocrine tumor in ectopic pancreatic tissue

Cited by 11 publications

References 0 publications

Premalignant and Malignant Lesions of the Heterotopic Pancreas in the Esophagus: a Case Report and Review of the Literature

Premalignant and Malignant Lesions of the Heterotopic Pancreas in the Esophagus: a Case Report and Review of the Literature

A Rare Case of Well-Differentiated Neuroendocrine Tumor Arising From a Jejunal Pancreatic Heterotopia

Intestinal Heterotopic Pancreas Involved by Simultaneous PanIN-2 Lesion and Endocrine Microadenoma: a Unique Case

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