A resolution approach of racemic phenylalanine with aqueous two-phase systems of chiral tropine ionic liquids

Wu, Haoran; Yao, Shun; Qian, Guofei; Yao, Tian; Song, Hang

doi:10.1016/j.chroma.2015.09.058

Cited by 49 publications

(41 citation statements)

References 37 publications

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“…Under the optimum conditions, the enantiomeric excess value of l -Phe in the middle phase of the IL-TPP was 65%, while the d -enantiomer remains in the IL-rich phase. 212 The obtained results prompted the authors 212 to conclude that this system could be a promising approach for the racemic resolution of amino acids. Although other conditions such as temperature and pH could be additionally evaluated to improve the selectivity, IL-TPP appears as a promising strategy for the separation of other enantiomers of high commercial interest.…”

Section: Amino Acidsmentioning

confidence: 98%

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Ionic-Liquid-Mediated Extraction and Separation Processes for Bioactive Compounds: Past, Present, and Future Trends

et al. 2017

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Ionic liquids (ILs) have been proposed as promising media for the extraction and separation of bioactive compounds from the most diverse origins. This critical review offers a compilation on the main results achieved by the use of ionic-liquid-based processes in the extraction and separation/purification of a large range of bioactive compounds (including small organic extractable compounds from biomass, lipids, and other hydrophobic compounds, proteins, amino acids, nucleic acids, and pharmaceuticals). ILs have been studied as solvents, cosolvents, cosurfactants, electrolytes, and adjuvants, as well as used in the creation of IL-supported materials for separation purposes. The IL-based processes hitherto reported, such as IL-based solid–liquid extractions, IL-based liquid–liquid extractions, IL-modified materials, and IL-based crystallization approaches, are here reviewed and compared in terms of extraction and separation performance. The key accomplishments and future challenges to the field are discussed, with particular emphasis on the major lacunas found within the IL community dedicated to separation processes and by suggesting some steps to overcome the current limitations.

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Section: Amino Acidsmentioning

confidence: 98%

“…ABS based on chiral tropine ILs and inorganic salts were prepared for the enantiomeric separation of a racemic mixture of Phe, 212 as depicted in Figure 14. In this study, the phase behavior of IL-based ABS was comprehensively investigated along with the factors that influence the separation efficiency.…”

Section: Amino Acidsmentioning

confidence: 99%

Ionic-Liquid-Mediated Extraction and Separation Processes for Bioactive Compounds: Past, Present, and Future Trends

et al. 2017

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“…21 In other relevant research, the separation efficiency was further improved by introducing tropine-based cation into the AAIL. 22 Despite these results show that CIL-based extraction is a very promising chiral separation technology, the difficulty in This article is protected by copyright. All rights reserved.…”

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confidence: 99%

Quantum chemistry calculation aided design of chiral ionic liquid‐based extraction system for amlodipine separation

Ding

Chen

et al. 2018

AIChE Journal

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Amlodipine is a widely used medication in treating hypertension, which is also known as a chiral compound. So far efforts have been made to obtain optically pure (S)‐amlodipine because (R)‐amlodipine has poor efficacy and is related to undesirable side effects. However, the available separation methods for amlodipine are still unsatisfactory. Recently, chiral separation has become a promising application of chiral ionic liquids (CILs), because the structural designability enables them adjustable separation efficiency for specific tasks. In this work, a high‐efficient CIL‐based liquid–liquid extraction system was developed for racemic amlodipine separation with the assistance of quantum chemistry calculations. Enantioselectivity up to 1.35 achieved by the novel system at 298.15 K is significantly higher than other available extraction systems. Moreover, the recycling of CIL can be easily realized by backward extraction of amlodipine, which is important for the industrial application of CILs. © 2018 American Institute of Chemical Engineers AIChE J, 64: 4080–4088, 2018

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“…However, some ionic liquids are toxic and expensive and an adequate selection of the compound to use should be made to avoid problems related to biocompatibility, toxicity and economical constrains . In general, ionic liquid‐based ATPS have found a niche in the recovery of small molecular weight compounds such as saccharides, synthetic antibiotics and aromatic molecules; but because of these characteristics the use of ionic liquids in novel ATPS tools is still far away from implementation in novel ATPS tools since not enough information is available regarding all the kinds of molecules that can potentially be separated using these kinds of systems. However, ionic liquid‐based ATPS are starting to be used in the recovery and fractionation of macromolecules such as proteins and enzymes, even when the complete mechanisms of partition in these kinds of systems are still under investigation .…”

Section: Upcoming Applications Provided By Novel Phase Forming Chemicalsmentioning

confidence: 99%

Novel aspects and future trends in the use of aqueous two‐phase systems as a bioengineering tool

González‐Valdez

Mayolo‐Deloisa

Rito‐Palomares

2017

J of Chemical Tech & Biotech

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Traditionally, aqueous two-phase systems (ATPS) have been used as a liquid-liquid extraction technique for the primary recovery and purification of biological samples. The enormous potential of their usage comes with great economical and technical advantages mainly due to the mild physicochemical environment. Nowadays, the use of ATPS as a bioengineering technique is approaching an era where new possibilities are being explored to maximize their use and implementation in the development of novel practical applications and tools. In this context, 'intelligent' polymers are being used as phase forming chemicals in ATPS in route to process integration. Extractive fermentation in ATPS is being re-evaluated with the aim of effectively growing microorganisms while recovering their fermentation products in different phases. ATPS are also being used as a tool for refolding of proteins. There are also several innovative efforts being made towards implementing this bioengineering tool as a continuous process moving away from traditional batch operations. In general, the possibilities of implementing ATPS in different bioprocessing aspects are growing considerably and gaining importance. This review aims to present the novel trends in the use and development of ATPS strategies as complete bioengineering tools and to provide a full perspective of their possibilities in the near future.

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A resolution approach of racemic phenylalanine with aqueous two-phase systems of chiral tropine ionic liquids

Cited by 49 publications

References 37 publications

Ionic-Liquid-Mediated Extraction and Separation Processes for Bioactive Compounds: Past, Present, and Future Trends

Ionic-Liquid-Mediated Extraction and Separation Processes for Bioactive Compounds: Past, Present, and Future Trends

Quantum chemistry calculation aided design of chiral ionic liquid‐based extraction system for amlodipine separation

Novel aspects and future trends in the use of aqueous two‐phase systems as a bioengineering tool

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