A resilient and luminescent stimuli-responsive hydrogel from a heterotopic 1,8-naphthalimide-derived ligand

Hawes, Chris S.; Lynes, Amy D.; Byrne, Kevin; Schmitt, Wolfgang; Ryan, Gavin; Möbius, Matthias E.; Gunnlaugsson, Thorfinnur

doi:10.1039/c7cc03482b

Cited by 25 publications

(6 citation statements)

References 37 publications

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“…Furthermore, these physical observations of hydrogels 1–5 are corroborated by rheological experiments (Figures S12 and ). The rheological experiments were performed to evaluate the mechanical strength of hydrogels 1–5 . ,, The viscoelastic nature of the hydrogels are confirmed by amplitude sweep experiments (Figures S12a,c,e and a,b). The amplitude sweep experiments were performed to evaluate the exact strain percent where the linear viscoelastic (LVE) region is valid for hydrogels 1–5 .…”

Section: Resultsmentioning

confidence: 96%

“…The shifting of amide I toward the lower wavenumber suggests a more ordered structure present in hydrogel 4 owing to the involvement of noncovalent interactions between peptide 1 and CD molecules (Figure a) . The FTIR spectrum of hydrogel 4 reveals a β-sheet like structure of peptides with an antiparallel arrangement. ,, The coassembly of peptide 1 and CD was further investigated by PXRD spectroscopy (Figure b). ,, The PXRD spectrum of CD shows characteristic sharp peaks at 2Θ = 9.47, 10.80, 12.72, and 13.40°, respectively, which suggest a high degree of crystallinity of CD with cage-like structure (Figure b) . These characteristic peaks of CD may associate with the cavity diameter (6–6.5 Å) and height of the CD ring (7.9 Å) .…”

Section: Resultsmentioning

confidence: 99%

“…31,66,67 The coassembly of peptide 1 and CD was further investigated by PXRD spectroscopy (Figure 3b). 40,59,64 The PXRD spectrum of CD shows characteristic sharp peaks at 2Θ = 9.47, 10.80, 12.72, and 13.40°, respectively, which suggest a high degree of crystallinity of CD with cage-like structure (Figure 3b). 40 These characteristic peaks of CD may associate with the cavity diameter (6−6.5 Å) and height of the CD ring (7.9 Å).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Evaluation of a Peptide-Based Coassembled Nanofibrous and Thixotropic Hydrogel for Dermal Wound Healing

Gavel

Kumar

Parmar

et al. 2020

ACS Appl. Bio Mater.

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The development of a peptide-based coassembled thixotropic hydrogel is a promising biomaterial, which could be used for dermal wound healing application. Cyclodextrins are widely used as biocompatible cyclic oligosaccharides that have hydrophilic exterior and hydrophobic interior for the formation of functional biomaterials. The current work presents a paradigm of a coassembled hydrogel with suitable mechanical strength that exhibits in vivo wound healing efficacy. In this report, we have designed and synthesized an Amoc (9-anthracenemethoxycarbonyl)-capped dipeptide, which self-assembles into a tough and robust hydrogel owing to participation of various noncovalent interactions. The mechanical strength of the self-assembling peptide-based hydrogel is tuned by incorporation of equimolar β-cyclodextrin (CD), which leads to the formation of a coassembled hydrogel suitable for wound healing application. The coassembled hydrogel exhibits simple syringe injectability and is thixotropic in nature. The nanostructural morphology of the coassembled hydrogel reveals a highly cross-linked and entangled nanofibrillar network. Several spectroscopic data elucidate the presence of noncovalent interactions between CD and peptide, which could be the driving force for the formation of ordered nanostructures. The coassembled hydrogel shows potent antibacterial activity against Gram-positive pathogenic bacteria. In vitro biocompatibility of the coassembled hydrogel has been investigated with the human embryonic kidney (HEK293) and MCF-7 cell lines. Additionally, confocal laser scanning microscopic data show cellular uptake of the coassembled hydrogel with blue fluorescence. Moreover, the in vivo wound healing activity of the coassembled hydrogel has been investigated by the histopathology study. The biochemical parameters such as nitric oxide and collagen contents have been evaluated by Griess and hydroxy proline assays. All the results corroborate the wound healing efficacy of a nanofibrillar antibacterial coassembled hydrogel.

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Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of a Peptide-Based Coassembled Nanofibrous and Thixotropic Hydrogel for Dermal Wound Healing

Gavel

Kumar

Parmar

et al. 2020

ACS Appl. Bio Mater.

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“…Temperature, pressure, light, electric and magnetic fields are examples of physical stimuli. 170 The pH level, ionic strength, solvent composition, and the presence of particular molecular species are examples of chemical stimuli. 171 In contrast, biomedical stimuli involve reactions to antigens, ligands, and enzymes.…”

Section: Hydrogels: Synthesis Classifications Primary Biomedical Appl...mentioning

confidence: 99%

Extracellular Vesicles and Hydrogels: An Innovative Approach to Tissue Regeneration

Hashemi,

Ezati,

Nasr

et al. 2024

ACS Omega

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Extracellular vesicles have emerged as promising tools in regenerative medicine due to their inherent ability to facilitate intercellular communication and modulate cellular functions. These nanosized vesicles transport bioactive molecules, such as proteins, lipids, and nucleic acids, which can affect the behavior of recipient cells and promote tissue regeneration. However, the therapeutic application of these vesicles is frequently constrained by their rapid clearance from the body and inability to maintain a sustained presence at the injury site. In order to overcome these obstacles, hydrogels have been used as extracellular vesicle delivery vehicles, providing a localized and controlled release system that improves their therapeutic efficacy. This Review will examine the role of extracellular vesicle-loaded hydrogels in tissue regeneration, discussing potential applications, current challenges, and future directions. We will investigate the origins, composition, and characterization techniques of extracellular vesicles, focusing on recent advances in exosome profiling and the role of machine learning in this field. In addition, we will investigate the properties of hydrogels that make them ideal extracellular vesicle carriers. Recent studies utilizing this combination for tissue regeneration will be highlighted, providing a comprehensive overview of the current research landscape and potential future directions.

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“…Multiple external factors as pH, temperature, enzymes, light, redox species, and organic co‐solvents 21–25 can modulate SAPHs formation; in this context, recently, much attention was received by the influence of metal ions on obtainable structures 26 . It is well known that metals play numerous functional roles in biological systems (e.g., Zn and Ca in protein structure 27 ; Ca and Si in bone formation 28,29 ; Mn and Mg in DNA/RNA folding 30,31 ; and Fe, Co, Ni, Mn, and Cu in redox catalysis 31,32 ), and the possibility to insert them into supramolecular systems to increase the cross‐linking and the stability of hydrogels can modulate their own homeostasis in biological contexts 25 .…”

Section: Introductionmentioning

confidence: 99%

Modulation of hydrogel networks by metal ions

Manna

Florio

Natale

et al. 2023

Journal of Peptide Science

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Self‐assembling hydrogels are receiving great attention for both biomedical and technological applications. Self‐assembly of protein/peptides as well as organic molecules is commonly induced in response to external triggers such as changes of temperature, concentration, or pH. An interesting strategy to modulate the morphology and mechanical properties of the gels implies the use of metal ions, where coordination bonds regulate the dynamic cross‐linking in the construction of hydrogels, and coordination geometries, catalytic, and redox properties of metal ions play crucial roles. This review aims to discuss recent insights into the supramolecular assembly of hydrogels involving metal ions, with a focus on self‐assembling peptides, as well as applications of metallogels in biomedical fields including tissue engineering, sensing, wound healing, and drug delivery.

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A resilient and luminescent stimuli-responsive hydrogel from a heterotopic 1,8-naphthalimide-derived ligand

Abstract: The preparation of functional supramolecular constructs is an area of significant interest in the materials science community, and as the field continues to mature, a prevalent focus for such materials is now the incorporation of stimuli-responsive properties for specific applications.

Cited by 25 publications

References 37 publications

Evaluation of a Peptide-Based Coassembled Nanofibrous and Thixotropic Hydrogel for Dermal Wound Healing

Evaluation of a Peptide-Based Coassembled Nanofibrous and Thixotropic Hydrogel for Dermal Wound Healing

Extracellular Vesicles and Hydrogels: An Innovative Approach to Tissue Regeneration

Modulation of hydrogel networks by metal ions

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