A Research Methodology for Studying Complex Service Systems

Solid-State Dispersions Employing Urethan

“…Drugs may be poorly soluble in GI fluids, leading to difficult and erratic absorption when administered orally. Absorption of insoluble medicaments is sometimes a function of the dissolution rate of these substances in aqueous solutions (10)(11)(12). Solid solutions or dispersions may function to increase dissolution rates by breaking Figure 1-Griseofuluin dissolution in pH 6.65 phosphate buffer (500 ml) at 37" and 60 rpm.…”

Bioavailability of 11 Sulfisoxazole Products in Humans

“…Keyphrases Chlorpromazine-effects on pressor actions'of serotonin, angiotensin, and bradykinin in perfused human placenta Prochlorperazine-effects on pressor actions of serotonin, angiotensin, and bradykinin in ' perfused human placenta Trifluoperazine-effects on pressor actions of serotonin, angiotensin, and bradykinin in perfused human placenta Serotonin-pressor actions in perfused human placenta, effects of chlorpromazine, prochlorperazine, and trifluoperazine 0 Angiotensin-pressor actions in perfused human placenta, effects of chlorpromazine, prochlorperazine, and trifluoperazine 0 Bradykinin-pressor actions in perfused human placenta, effects of chlorpromazine, prochlorperazine, and trifluoperazine 0 Autacoid antagonism-effects of chlorpromazine, prochlorperazine, and trifluoperazine on pressor actions of serotonin, angiotensin, and bradykinin in perfused human placenta 0 Phenothiazines-chlorpromazine, prochlorperazine, and trifluoperazine, effects on pressor actions of serotonin, angiotensin, and bradykinin in perfused human placenta It is well established that the endogenous autacoids serotonin, angiotensin, and bradykinin are present and that their levels fluctuate in human placental and/or related tissues (1)(2)(3)(4)(5)(6)(7)(8). Several investigations linked high blood levels of angiotensin (9), renin (lo), and serotonin (11) to the pathogenesis of the toxemias of pregnancy.…”