A requirement for autophagy in HMGA2-induced metabolic reprogramming to support Cd-induced migration

Hasenbilige,; Mei, Junjie; Dlamini, Mongameli B.; Gao, Zeyun; Jiang, Liping; Li, Qiujuan; Chen, Geng; Shi, Xiaoxia; Liu, Yong; Kong, Ying; Cao, Jun

doi:10.1016/j.tox.2021.152928

Cited by 4 publications

(1 citation statement)

References 43 publications

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“… 68 Wang et al 69 found that cadmium-induced glycolysis was autophagy-dependent and that the autophagy-glycolysis axis plays an important role in the proliferation of A549 cells treated with cadmium. Hasenbilige et al 70 showed that GLUT1, HKII, LDHA, and PKM2 were significantly inhibited in HMGA2-overexpressed A549 cells treated with the autophagy inhibitor, 3-MA, indicating that autophagy is involved in HMGA2-mediated glycolysis in A549 cells, which is essential for cadmium-induced migration. In addition, Let-7-mediated and mTOR-dependent autophagy were reported to participate in glucose metabolism.…”

Section: The Role Of Autophagy In Regulating Glycolysis In Cancer Pro...mentioning

confidence: 99%

Autophagy and Glycometabolic Reprograming in the Malignant Progression of Lung Cancer: A Review

Li,

Liu,

Wang

et al. 2023

Technol Cancer Res Treat

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Lung cancer is one of the leading causes of cancer-related deaths worldwide. However, there are currently limited treatment options that are widely available to patients with advanced lung cancer, and further research is required to inhibit or reverse disease progression more effectively. In lung and other solid tumor cancers, autophagy and glycometabolic reprograming are critical regulators of malignant development, including proliferation, drug resistance, invasion, and metastasis. To provide a theoretical basis for therapeutic strategies targeting autophagy and glycometabolic reprograming to prevent lung cancer, we review how autophagy and glycometabolism are regulated in the malignant development of lung cancer based on research progress in other solid tumors.

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Section: The Role Of Autophagy In Regulating Glycolysis In Cancer Pro...mentioning

confidence: 99%