A reproductive role for the nonapeptides vasotocin and isotocin in male zebrafish (Danio rerio)

Altmieme, Zeinab; Jubouri, Mais; Touma, K.; Cote, G.; Fonseca, Marise Oliveira; Julian, Tess; Mennigen, Jan A.

doi:10.1016/j.cbpb.2019.110333

Cited by 12 publications

(22 citation statements)

References 70 publications

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“…In addition to oxtr paralogues, the expression of other teleost nonapeptide receptors and in some instances specific paralogues have been localized to tissues relevant to teleost reproduction (63)(64)(65)(66)(67)(68)(69)(70)(71)(72)(73) and are summarized in Table 3. Much of our current information on reproductive roles of nonapeptides has been derived from studies of otocephalan species including the airbreathing catfish (4, 5, 24, 84), goldfish (85-87), and zebrafish (35). Given that the nonapeptide repertoire is characterized by genomic rearrangements and potentially important AA sequence changes in this clade, caution is warranted when attempting to generalize functionality across all teleosts.…”

Section: The Teleost Nonapeptide Receptor Repertoirementioning

confidence: 99%

“…In male beaugregory damselfish, Stegastes leucostictus , Manning’s compound significantly lowered male courtship behaviour, while exogenous Avp administration did not affect male courtship behaviour ( 120 ). Similarly, administration of Manning’s compound significantly reduced male reproductive courtship behaviour and reproductive success in mating assays with female zebrafish, Danio rerio without affecting whole body androgen (T and 11-keto-testosterone; 11-KT) levels, suggesting Avp acutely regulates male zebrafish courtship behaviour including chasing, nudging, and circling via central Avpr1a receptors and independently of HPG axis regulation ( 35 ). In the weakly electric fish, Brachyhypopomus gauderio , male courtship behaviour observed in male-female dyads resulted in a higher degree of Avp neuron activation in the nucleus preopticus ventricularis anterior compared to isolated males ( 121 ).…”

Section: Reproductive Function Of Nonapeptides In Teleost Fishesmentioning

confidence: 99%

“…In fish species in which specific sensory modalities have been shown to play a key role in reproductive behaviours, nonapeptide innervation has been described for distinct brain regions involved in sending and receiving sensory information. For example, in male zebrafish, Danio rerio , known to respond to female sex pheromones ( 34 ), fibers positive for Oxt have been identified in the olfactory bulb ( 35 ). In the plainfin midshipman, Porichtys notatus , which relies on vocalization as part of their courtship behaviour ( 36 ), especially Avp but also Oxt innervation was found in fore- and mid-brain regions involved in vocalization, and diencephalic regions of the ascending auditory pathway ( 37 , 38 ).…”

Section: Introductionmentioning

confidence: 99%

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Reproductive roles of the vasopressin/oxytocin neuropeptide family in teleost fishes

et al. 2022

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The vertebrate nonapeptide families arginine vasopressin (AVP) and oxytocin (OXT) are considered to have evolved from a single vasopressin-like peptide present in invertebrates and termed arginine vasotocin in early vertebrate evolution. Unprecedented genome sequence availability has more recently allowed new insight into the evolution of nonapeptides and especially their receptor families in the context of whole genome duplications. In bony fish, nonapeptide homologues of AVP termed arginine vasotocin (Avp) and an OXT family peptide (Oxt) originally termed isotocin have been characterized. While reproductive roles of both nonapeptide families have historically been studied in several vertebrates, their roles in teleost reproduction remain much less understood. Taking advantage of novel genome resources and associated technological advances such as genetic modifications in fish models, we here critically review the current state of knowledge regarding the roles of nonapeptide systems in teleost reproduction. We further discuss sources of plasticity of the conserved nonapeptide systems in the context of diverse reproductive phenotypes observed in teleost fishes. Given the dual roles of preoptic area (POA) synthesized Avp and Oxt as neuromodulators and endocrine/paracrine factors, we focus on known roles of both peptides on reproductive behaviour and the regulation of the hypothalamic-pituitary-gonadal axis. Emphasis is placed on the identification of a gonadal nonapeptide system that plays critical roles in both steroidogenesis and gamete maturation. We conclude by highlighting key research gaps including a call for translational studies linking new mechanistic understanding of nonapeptide regulated physiology in the context of aquaculture, conservation biology and ecotoxicology.

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Section: The Teleost Nonapeptide Receptor Repertoirementioning

confidence: 99%

Section: Reproductive Function Of Nonapeptides In Teleost Fishesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Reproductive roles of the vasopressin/oxytocin neuropeptide family in teleost fishes

et al. 2022

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“…The main roles of AVT in fish are related to the antidiuretic function (Kulczykowska 1997, Martos-Sitcha et al 2013, the response to stress conditions (Fryer & Leung 1982, Gesto et al 2014, Martos-Sitcha et al 2019 and the behavioral and physiological regulation of reproduction (Foran & Bass 1999, Bass & Grober 2001, Sokołowska et al 2015, Altmieme et al 2019. We were able to confirm that hydrostatic pressure exposure per se does not elicit a stress response in trout since plasma cortisol levels were not elevated (Barton & Iwama 1991).…”

Section: Discussionmentioning

confidence: 65%

High hydrostatic pressure effects on arginine vasotocin levels in fish

Rodrı́guez-Illamola

Míguez

Coimbra³

et al. 2020

Aquat. Biol.

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The present study investigates the response of the hormone arginine vasotocin (AVT), the non-mammalian antidiuretic hormone, to the acclimation of fish to high hydrostatic pressure (5.1 MPa). Two fish species with different osmoregulatory strategies, the lesser spotted dogfish Scyliorhinus canicula, a marine osmoconforming chondrichthyan species adapted for migration to deep waters, and the rainbow trout Oncorhynchus mykiss, a pressure-sensitive freshwater species, were selected for study. Fish were exposed to hydrostatic pressures of either 0.1 (control) or 5.1 MPa in hydrostatic chambers for up to 2 wk at their appropriate salinities. Plasma cortisol was measured in trout, and plasma chloride, sodium and potassium were measured in both fish species. A transient high level of plasma AVT was found in dogfish and in trout after 1 and 3 d of exposure to high hydrostatic pressure, which returned to basal levels by 14 d of exposure. In contrast, pituitary AVT content was reduced after short-term exposure in dogfish, while in trout, lower expression was found in high pressure than in control conditions, independently of exposure time. In dogfish, pituitary AVT levels recovered by 14 d under high hydrostatic pressure. No changes in plasma cortisol (trout) or ions (both species) were observed. These initial increases of the AVT release from the pituitary during fish acclimation to high pressure suggest that it works as a physiological short-term response to reduce water loss and equilibrate ion osmotic balance.

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“…So there is a prime need to modify the available hormonal formulations that have been used to stimulate the reproductive physiology in fish. Nonapeptides are the hormones of choice to be used for the purpose due to their multiple reproductive roles in fish ( 8 , 10 – 12 ).…”

Section: Introductionmentioning

confidence: 99%

Teleost Nonapeptides, Isotocin and Vasotocin Administration Released the Milt by Abdominal Massage in Male Catfish, Clarias magur

et al. 2022

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In the present work the nonapeptides i.e., isotocin and vasotocin alone or in a combination were tested in C. magur to evaluate their effect on stripping by abdominal massage. Also, we used chitosan-carbon nanotube nanocomposites to conjugate the nonapetides isotocin (abbreviated as COOH-SWCNTCSPeP) and isotocin and vasotocin (COOH-SWCNTCSPePs) with the aim of sustaining the effect for a longer duration. The conjugation of nonapeptides with nanocomposites was confirmed by Fourier-transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), Thermogravimetric analysis (TGA) and X-ray photoelectron spectroscopy (XPS). Two experiments were conducted to study the effect of naked (without nanoparticles) and conjugated nonapeptides on the milt release by stripping. Both the experiments consisted of eight treatments which included four naked groups two nanoconjugated groups and two controls. Both naked and nonconjugated formulations were successful in stripping the male catfish. The mRNA expression of selected reproductive genes was analysed to decipher the effect of nanopeptides at the molecular level. Nonapeptide treatment either naked or nanoconjugated, resulted in the upregulation of the transcript level of genes. Histological analysis revealed the concentration of spermatozoa was more in peptide injected groups than in the controls. The synergistic effects of nonapeptides and Ovatide had a positive impact on GSI. Thus, the present formulations were successful in stripping the male catfish to obtain the milt with significant reproductive success. Even though the naked groups perform better but the number of males required to fertilize the eggs in nanoconjuagted groups was smaller making it worth using for the delivery of nonapeptides.

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A reproductive role for the nonapeptides vasotocin and isotocin in male zebrafish (Danio rerio)

Cited by 12 publications

References 70 publications

Reproductive roles of the vasopressin/oxytocin neuropeptide family in teleost fishes

Reproductive roles of the vasopressin/oxytocin neuropeptide family in teleost fishes

High hydrostatic pressure effects on arginine vasotocin levels in fish

Teleost Nonapeptides, Isotocin and Vasotocin Administration Released the Milt by Abdominal Massage in Male Catfish, Clarias magur

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