A reporter virus particle seroneutralization assay for tick‐borne encephalitis virus overcomes ELISA limitations
Rahel Ackermann‐Gäumann,
Alexis Dentand,
Reto Lienhard
et al.
Abstract:Tick‐borne encephalitis (TBE) virus is the most prevalent tick‐transmitted orthoflavivirus in Europe. Due to the nonspecific nature of its symptoms, TBE is primarily diagnosed by ELISA‐based detection of specific antibodies in the patient serum. However, cross‐reactivity between orthoflaviviruses complicates the diagnosis. Specificity issues may be mitigated by serum neutralization assays (SNT), although the handling of clinically relevant orthoflaviviruses requires biosafety level (BSL) 3 conditions and they … Show more
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