A reported death case of a novel bunyavirus in Shanghai, China

Abstract

This paper describes the first case of infection with a recently described novel bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV), in Shanghai, China. The case is originally from Chizhou City, Anhui province within an endemic area for SFTSV. We describe the etiology, epidemiological characteristics, clinical diagnosis and treatment of this fatal case. This case is unique because major cause of death was renal failure, whereas other reported cases have been due to hemorrhage. The investigation and response to this case provides meaningful insight for the early and rapid diagnosis, treatment, prevention and control of severe fever with thrombocytopenia syndrome virus in non-endemic regions in China and globally.

Impact of Subolesin and Cystatin Knockdown by RNA Interference in Adult Female Haemaphysalis longicornis (Acari: Ixodidae) on Blood Engorgement and Reproduction

“…Among Ixodidae, Haemaphysalis longicornis was reported to transmit a wide variety of pathogens, including Babesia spp., Anaplasma bovis , Theileria spp., Coxiella burnetii , Ehrlichia chaffeensis , spotted fever group rickettsiae, and severe fever with thrombocytopenia syndrome (SFTS) virus throughout China, Korea, and Japan [ 8 , 9 , 10 , 11 , 12 , 13 , 14 ].…”

No Detection of Severe Fever with Thrombocytopenia Syndrome Virus from Ixodid Ticks Collected in Seoul

“…Haemaphysalis longicornis is an important vector of zoonotic tick-borne pathogens that impact on medical and veterinary health worldwide [ 1 ]. Severe fever with thrombocytopenia syndrome (SFTS) virus is a tick-borne virus transmitted by H. longicornis and included in the family Bunyaviridae (genus Phlebovirus) [ 2 , 3 , 4 , 5 ].…”

Apodemus agrarius is a potential natural host of severe fever with thrombocytopenia syndrome (SFTS)—causing novel bunyavirus

“…A disease similar to SFTS has been reported in Missouri, U.S.A [6]. This life-threatening disease can affect people at any age [7][8][9][10][11]. Importantly, human-to-human transmission of SFTSV was documented in a family cluster in China [12].…”

“…However, little is known about the epidemiology of SFTS in the eastern coastal region of China [10,11]. Ningbo is located close to eastern coast of China and south-east corner of the Yangtze River, and belongs to a north subtropical monsoon climate zone with an annual average temperature of 16.4 • C.…”