A report on three patients with Echinococcus multilocularis: Lessons learned

Bansal, Nalini; Vij, Vivek; Rastogi, Mukul; Wadhawan, Manav; Kumar, Ajay

doi:10.1007/s12664-018-0860-y

Cited by 9 publications

(12 citation statements)

References 11 publications

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“…Confusion between alveolar echinococcosis disease and neoplasia appears to be a major challenge in human medicine, in which alveolar echinococcosis may not be spontaneously included in the differential diagnoses in geographical areas where the disease is uncommon (Atanasov et al, 2013;Bansal et al, 2018). In a recent case report, hepatic E. multilocularis infection with pulmonary nodules was misdiagnosed as a cholangiocarcinoma with lung metastases in a 38-year-old woman from the Czech Republic living in Germany (Pohnan et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Medicamenteuze behandeling van een Echinococcus multilocularis-infectie die een lokaal agressieve cavitaire tumor met longmetastasen nabootst bij een hond

Fritz¹,

Mahinc²,

Rannou³

et al. 2019

Vlaams Diergeneeskundig Tijdschrift

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A two-year-old Labrador retriever living in the French Alps was presented with abdominal distension, lethargy and weight loss but no other specific clinical signs. CT examination revealed a large, cavitary liver mass invading the caudal vena cava, associated with multiple hepatic lesions of similar appearance, lymphadenopathy and pulmonary nodules. The condition was initially mistaken for a malignant neoplasm. However, cytologic and histologic examinations of the largest liver mass were consistent with cestodiasis and PCR testing confirmed infection with Echinococcus multilocularis. Medical treatment with albendazole was initiated. The dog remained clinically well for ten months following the diagnosis, but had to be euthanized because the owners had to return to Great-Britain and the dog could not be legally imported. To the authors’ knowledge, this is the first case report, in which long-term follow-up of Echinococcus sp. infection in a dog, managed medically, is described. This case also shows that medical management may be a viable option in case surgery is not feasible.

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Section: Discussionmentioning

confidence: 99%

Medicamenteuze behandeling van een Echinococcus multilocularis-infectie die een lokaal agressieve cavitaire tumor met longmetastasen nabootst bij een hond

Fritz¹,

Mahinc²,

Rannou³

et al. 2019

Vlaams Diergeneeskundig Tijdschrift

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“…Noticeably, a paper from the UK showed an Afghan patient who migrated from Pakistan; the authors discuss the infection originating in Afghanistan [22]. There was evidence of isolated cases in India and, as far as we know, the first case was reported in Pakistan [23][24][25][26][27][28][29][30].…”

Section: -2011mentioning

confidence: 99%

Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty-first century

et al. 2019

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Purpose Human alveolar echinococcosis (AE) is a potentially lethal zoonosis caused by the cestode Echinococcus multilocularis. The aim of this systematic review is to establish a comprehensive global AE literature overview taking into account the epidemiologically relevant AE research of the twenty-first century. Methods We systematically searched the global literature published from 2001 through 2018 via MEDLINE, EMBASE, the Russian databases eLIBRARY.RU, CyberLeninka, the Chinese databases CNKI, VIP, Journals.research.ac.ir (Farsi language-based), Jordan E-Library (Arab language-based) and supplementary Google Scholar, in accordance with the PRISMA guidelines. QGIS software was used for the mapping of the affected countries. Results We have listed 154 relevant publications in the final literature synopsis in consideration of our quality assessment. Including non-autochthonous cases, human AE was reported in 36 countries within the northern hemisphere from 2001 to 2018. The first publication of AE in Tajikistan,

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“…ELISA test (Echinococcus IgG) was positive -50 NTU (positive above 11NTU) and confirmed with positive Western-blot which revealed presence of specific for Echinococcus multilocularis IgG (7,16,18,(26)(27)(28). ELISA EM2-plus (anty-E.multilocularis) was also high positive (> 3.0ABS).…”

Section: Case Presentationmentioning

confidence: 63%

“…Within the liver, the parasite's unrestricted growth is responsible for focal calicifications and finally the whole necrosis. Due to vascular and neural invasion Buddi-Chiari syndrome may be the clinical presentation of this condition [26].…”

Section: Discussion and Conclussionsmentioning

confidence: 99%

Portal hypertension as a result of the incomplete surgically treated advanced alveolar echinococcosis: a case description

et al. 2020

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Background: Infection of Echinococcus multilocularis causes in humans the alveolar echinococcosis. Although the infection has worldwide distribution it is rarely detected. Diagnosis of alveococcosis is difficult because of not typical clinical picture and irregular results of radiological examinations suggesting neoplasmatic process which begins in the liver tissue or in the biliary tracts. The parasitic growth is slow, so the illness is quite often established in late invasion period. Treatment of long-lasting and late diagnosed infection is difficult and requires cooperation of parasitologists together with surgeons to avoid life-threatening organ dysfunction. Case presentation: We describe a young male patient, diagnosed, according to the radiological, immunological and histological examination results, infection of Echinococcus multilocularis, who was treated with not radical resection of pathologic mass together with persistent albendazole intake. The right hepatectomy was performed. In addition, visible cysts were removed from the left lobe of the liver in nonanatomical resection and suspicious calcified lesions in hepatoduodenal ligament were also removed. After the operation portal hypertension, with splenomegaly and symptoms of the liver cirrhosis occurred (thrombocytopenia, collateral venous circulation, first degree varices oesophagii). The portal hypertension probably could be a result of incomplete surgery due to extended parasitic infection and liver anathomical changes due to performed procedures, because the portal hypertension and it's further complications had not been observed before the operation. Conclusions: Echinococcus multilocularis should be taken under consideration in differential diagnosis of irregular lesions within the liver. Lon-lasting invasion could be responsible for the irreversible secondary liver changes such as cirrhosis and portal hypertension. The surgery treatment (treatment of choice) is difficult and it's results depends on the invasion period the patient is operated on. After the surgery the patient requires careful followup, to detect early complications.

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A report on three patients with Echinococcus multilocularis: Lessons learned

Cited by 9 publications

References 11 publications

Medicamenteuze behandeling van een Echinococcus multilocularis-infectie die een lokaal agressieve cavitaire tumor met longmetastasen nabootst bij een hond

Medicamenteuze behandeling van een Echinococcus multilocularis-infectie die een lokaal agressieve cavitaire tumor met longmetastasen nabootst bij een hond

Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty-first century

Portal hypertension as a result of the incomplete surgically treated advanced alveolar echinococcosis: a case description

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