A report on the large measles outbreak in Lyon, France, 2010 to 2011

Huoi, Catherine; Casalegno, Jean Sébastien; Bénet, Thomas; Neuraz, Antoine; Billaud, Geneviève; Eibach, Daniel; Mekki, Yahia; Rudigoz, R.-C.; Massardier, Jérôme; Huissoud, Cyril; Massoud, Mona; Gaucherand, P.; Claris, Olivier; Gillet, Yves; Floret, D.; Lina, Bruno; Vanhems, Philippe

doi:10.2807/ese.17.36.20264-en

Cited by 21 publications

(3 citation statements)

References 14 publications

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“…2,[4][5][6] A large proportion of cases (Range,15.9%-32.0%) were reported in infants <1 year of age, a group of them were at high risk for the development of Measles-related complications and mortality. [7][8][9][10][11] Measles outbreaks can serve as a tracer indicator of health inequities and can help identify gaps in immunization programs and primary health care systems. 12 Measles outbreaks are occurring after years where countries have failed to achieve and maintain 95% coverage with two doses of Measles vaccine at national and subnational levels.…”

Section: Resultsmentioning

confidence: 99%

Measles Infection and Vaccination Status against Measles in Children during 2019-2020: A Hospital Based Study in Chattogram

Ferdousi,

Datta,

Mamtaz

et al. 2023

Chatt Maa Shi Hosp Med Coll J

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Background: Despite widespread availability of a safe and cost-effective vaccine, Measles outbreak is reported from different regions of Bangladesh in the recent past. This study was aimed to Identify the related features of Measles infection in children during the upsurge of Measles infection in Chattogram during 2019-2020, when Bangladesh was about to achieve Measles elimination. Materials and methods: This prospective observational study included all the Measles infected children admitted in the Pediatric Ward of Chittagong Medical College Hospital, Chattogram during the period from September 2019-February 2020. In this hospital patients up to 12 years after neonatal period are admitted. Patients whose guardian did not give consent were excluded. Measles cases were diagnosed clinically according to case definition criteria by WHO. Demographic, clinical features, Measles vaccination status of both affected children & their mother and associated complications were recorded in a predesigned form. Data were analyzed and results were given in a tabulated form. The aim of this study was to evaluate the characteristics of Measles infection and their vaccination status in children during its upsurge in 2019-2020. Results: Affected children 13(20%) were suffered in spite of vaccination. Among the 65 affected children 44 (67.6%) were below one year of age, youngest one was 2 months old. Male to female ratio was 1.8:1. 80% (n=52) children were not vaccinated, 35 of them not yet attained the age of vaccination. 17 children attained the age but vaccination was delayed due to cough and cold, fever, bronchopneumonia or Measles itself. Complications were common among them, Bronchopneumonia 47 (72.3%) and Purulent conjunctivitis 38 (58.5%). There was no case fatality. Conclusion: Children are being affected by Measles before attaining the age of first dose of vaccination and incompletely vaccinated or unvaccinated children have a role in the upsurge of Measles. Chatt Maa Shi Hosp Med Coll J; Vol.22 (1); January 2023; Page 33-37

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Section: Resultsmentioning

confidence: 99%

Measles Infection and Vaccination Status against Measles in Children during 2019-2020: A Hospital Based Study in Chattogram

Ferdousi,

Datta,

Mamtaz

et al. 2023

Chatt Maa Shi Hosp Med Coll J

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“…The relatively small proportion of vaccinated cases during this outbreak, compared with other outbreaks in Europe [23–27], limited the power of our analyses. Another limitation is that we could not distinguish the role of primary or secondary vaccine failure since we lacked information on the immune response and avidity levels [28] of vaccinated cases.…”

Section: Discussionmentioning

confidence: 99%

Effect of vaccination on severity and infectiousness of measles during an outbreak in the Netherlands, 2013–2014

et al. 2020

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An outbreak of measles in the Netherlands in 2013–2014 provided an opportunity to assess the effect of MMR vaccination on severity and infectiousness of measles. Measles is notifiable in the Netherlands. We used information on vaccination, hospitalisation, complications, and most likely source(s) of infection from cases notified during the outbreak. When a case was indicated as a likely source for at least one other notified case, we defined it as infectious. We estimated the age-adjusted effect of vaccination on severity and infectiousness with logistic regression. Of 2676 notified cases, 2539 (94.9%) were unvaccinated, 121 (4.5%) were once-vaccinated and 16 (0.6%) were at least twice-vaccinated; 328 (12.3%) cases were reported to have complications and 172 (6.4%) cases were hospitalised. Measles in twice-vaccinated cases led less often to complications and/or hospitalisation than measles in unvaccinated cases (0% and 14.5%, respectively, aOR 0.1 (95% CI 0–0.89), P = 0.03). Of unvaccinated, once-vaccinated and twice-vaccinated cases, respectively, 194 (7.6%), seven (5.1%) and 0 (0%) were infectious. These differences were not statistically significant (P > 0.05). Our findings suggest a protective effect of vaccination on the occurrence of complications and/or hospitalisation as a result of measles and support the WHO recommendation of a two-dose MMR vaccination schedule.

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“…The estimated origins of imported cases also varied from year to year, and often correlated with trends in incidence in potential countries of origin (Figure 2). In 2011, imported cases were predicted to have been predominantly from France, which experienced a large outbreak that year [20]. In other years, other countries predominated-notably, the United Kingdom in 2012, the Philippines in 2014, and the Netherlands in 2016.…”

Section: Predicting Measles Origin and Magnitudementioning

confidence: 99%

Air Passenger Travel and International Surveillance Data Predict Spatiotemporal Variation in Measles Importations to the United States

et al. 2021

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Measles incidence in the United States has grown dramatically, as vaccination rates are declining and transmission internationally is on the rise. Because imported cases are necessary drivers of outbreaks in non-endemic settings, predicting measles outbreaks in the US depends on predicting imported cases. To assess the predictability of imported measles cases, we performed a regression of imported measles cases in the US against an inflow variable that combines air travel data with international measles surveillance data. To understand the contribution of each data type to these predictions, we repeated the regression analysis with alternative versions of the inflow variable that replaced each data type with averaged values and with versions of the inflow variable that used modeled inputs. We assessed the performance of these regression models using correlation, coverage probability, and area under the curve statistics, including with resampling and cross-validation. Our regression model had good predictive ability with respect to the presence or absence of imported cases in a given state in a given year (area under the curve of the receiver operating characteristic curve (AUC) = 0.78) and the magnitude of imported cases (Pearson correlation = 0.84). By comparing alternative versions of the inflow variable averaging over different inputs, we found that both air travel data and international surveillance data contribute to the model’s ability to predict numbers of imported cases and individually contribute to its ability to predict the presence or absence of imported cases. Predicted sources of imported measles cases varied considerably across years and US states, depending on which countries had high measles activity in a given year. Our results emphasize the importance of the relationship between global connectedness and the spread of measles. This study provides a framework for predicting and understanding imported case dynamics that could inform future studies and outbreak prevention efforts.

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A report on the large measles outbreak in Lyon, France, 2010 to 2011

Abstract: Binary file ES_Abstracts_Final_ECDC.txt matches

Cited by 21 publications

References 14 publications

Measles Infection and Vaccination Status against Measles in Children during 2019-2020: A Hospital Based Study in Chattogram

Measles Infection and Vaccination Status against Measles in Children during 2019-2020: A Hospital Based Study in Chattogram

Effect of vaccination on severity and infectiousness of measles during an outbreak in the Netherlands, 2013–2014

Air Passenger Travel and International Surveillance Data Predict Spatiotemporal Variation in Measles Importations to the United States

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