A Report of Zika Virus Seroprevalence in Republic of the Congo

Nurtop, Elif; Moyen, Nanikaly; Dzia-Lepfoundzou, Amelia; Dimi, Yannick; Ninove, Laëtitia; Drexler, Jan Felix; Gallian, Pierre; Lamballerie, Xavier de; Priet, Stéphane

doi:10.1089/vbz.2019.2466

Cited by 7 publications

(8 citation statements)

References 17 publications

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“…The worldwide emergence of ZIKV raised international awareness, resulting in improved surveillance including the implementation of epidemiological studies in regions where the virus was known to be present prior to the pandemic. Seroprevalence studies recently conducted across Africa generally found a low level (<6.2%) of specific anti-ZIKV antibodies [71][72][73][74][75] . These studies are consistent with low-level ZIKV circulation in human populations of Africa and rule out the hypothesis that a high level of herd immunity is the main factor preventing ZIKV outbreaks in Africa.…”

Section: Discussionmentioning

confidence: 99%

“…aegypti is considered the main vector of transmission between humans in the urban cycle 1,2 . In the absence of an efficient urban vector, human ZIKV infections in Africa would be limited to spillover transmission events from the sylvatic cycle via bridge vectors, which could explain the low level of ZIKV circulation 75,77 . Large-scale human outbreaks of dengue, yellow fever and chikungunya presumably mediated by Ae.…”

Section: Discussionmentioning

confidence: 99%

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Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains

et al. 2021

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The global emergence of Zika virus (ZIKV) revealed the unprecedented ability for a mosquito-borne virus to cause congenital birth defects. A puzzling aspect of ZIKV emergence is that all human outbreaks and birth defects to date have been exclusively associated with the Asian ZIKV lineage, despite a growing body of laboratory evidence pointing towards higher transmissibility and pathogenicity of the African ZIKV lineage. Whether this apparent paradox reflects the use of relatively old African ZIKV strains in most laboratory studies is unclear. Here, we experimentally compare seven low-passage ZIKV strains representing the recently circulating viral genetic diversity. We find that recent African ZIKV strains display higher transmissibility in mosquitoes and higher lethality in both adult and fetal mice than their Asian counterparts. We emphasize the high epidemic potential of African ZIKV strains and suggest that they could more easily go unnoticed by public health surveillance systems than Asian strains due to their propensity to cause fetal loss rather than birth defects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains

et al. 2021

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“…A serum neutralization test for Zika virus detection identified a low seroprevalence in the country, with only seven healthy individuals (1.8%) having Zika virus antibodies. This investigation suggested a limited circulation of Zika virus in the Republic of Congo [188].…”

Section: Republic Of Congomentioning

confidence: 60%

Systematic Review of Important Viral Diseases in Africa in Light of the ‘One Health’ Concept

et al. 2020

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Emerging and re-emerging viral diseases are of great public health concern. The recent emergence of Severe Acute Respiratory Syndrome (SARS) related coronavirus (SARS-CoV-2) in December 2019 in China, which causes COVID-19 disease in humans, and its current spread to several countries, leading to the first pandemic in history to be caused by a coronavirus, highlights the significance of zoonotic viral diseases. Rift Valley fever, rabies, West Nile, chikungunya, dengue, yellow fever, Crimean-Congo hemorrhagic fever, Ebola, and influenza viruses among many other viruses have been reported from different African countries. The paucity of information, lack of knowledge, limited resources, and climate change, coupled with cultural traditions make the African continent a hotspot for vector-borne and zoonotic viral diseases, which may spread globally. Currently, there is no information available on the status of virus diseases in Africa. This systematic review highlights the available information about viral diseases, including zoonotic and vector-borne diseases, reported in Africa. The findings will help us understand the trend of emerging and re-emerging virus diseases within the African continent. The findings recommend active surveillance of viral diseases and strict implementation of One Health measures in Africa to improve human public health and reduce the possibility of potential pandemics due to zoonotic viruses.

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“…The worldwide emergence of ZIKV raised international awareness, resulting in improved surveillance including the implementation of epidemiological studies in regions where the virus was known to be present prior to the pandemic. Seroprevalence studies recently conducted across Africa generally found a low level (<6.2%) of specific anti-ZIKV antibodies [62][63][64][65][66] . These studies are consistent with low-level ZIKV circulation in human populations of Africa and rule out the hypothesis that a high level of herd immunity is the main factor preventing ZIKV outbreaks in Africa.…”

Section: Discussionmentioning

confidence: 99%

“…aegypti is considered the main vector of transmission between humans in the urban cycle 1,2 . In the absence of an efficient urban vector, human ZIKV infections in Africa would be limited to spillover transmission events from the sylvatic cycle via bridge vectors, which could explain the low level of ZIKV circulation 66,68 . Large-scale human outbreaks of dengue, yellow fever and chikungunya presumably mediated by Ae.…”

Section: Discussionmentioning

confidence: 99%

High transmissibility and fetal pathogenicity of recent Zika virus strains from the African lineage

Aubry

Jacobs

Darmuzey

et al. 2020

Preprint

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SummaryThe global emergence of Zika virus (ZIKV) in the last decade revealed the unprecedented ability for a mosquito-borne virus to cause congenital birth defects such as microcephaly. A puzzling aspect of ZIKV emergence is that all human outbreaks and birth defects to date have been exclusively associated with the Asian ZIKV lineage, despite a growing body of laboratory evidence pointing towards higher transmissibility and pathogenicity of the African ZIKV lineage. Whether this apparent paradox reflects the use of relatively old African ZIKV strains in most laboratory studies is unclear. Here, we experimentally compared the transmissibility and pathogenicity of seven low-passage ZIKV strains representing the recently circulating viral genetic diversity. We found that recent African ZIKV strains largely outperformed their Asian counterparts in mosquito transmission kinetics experiments, which translated into a markedly higher epidemic potential in outbreak computer simulations. In addition, African ZIKV strains were significantly more lethal than Asian ZIKV strains in immunocompromised adult mice. Finally, prenatal infection of immunocompetent mouse embryos with an African ZIKV strain resulted in embryonic death whereas it caused microcephaly with Asian ZIKV strains. Together, our results demonstrate the high epidemic potential and pathogenicity of recent ZIKV strains from Africa. Importantly, they also imply that the African ZIKV lineage could more easily go unnoticed by public health surveillance systems than the Asian ZIKV lineage due to its propensity to cause fetal loss rather than birth defects.

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A Report of Zika Virus Seroprevalence in Republic of the Congo

Cited by 7 publications

References 17 publications

Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains

Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains

Systematic Review of Important Viral Diseases in Africa in Light of the ‘One Health’ Concept

High transmissibility and fetal pathogenicity of recent Zika virus strains from the African lineage

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