A Report of Eight Cases, Including Four with a Malignant Spindle Cell Component

Clement, Philip B.; Young, Robert H.; Keh, Pacita; Östör, Andrew G.; Scully, Robert E.

doi:10.1097/00000478-199510000-00006

Cited by 154 publications

(102 citation statements)

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“…Some carcinosarcomas of the uterine cervix may be of mesonephric origin. 31 Before making a diagnosis of a primary carcinosarcoma of the cervix, spread from a uterine corpus primary should be excluded. Carcinosarcoma of the cervix with a squamous element should be distinguished from squamous carcinoma with a spindle cell component (spindle cell squamous carcinoma).…”

Section: Differential Diagnosismentioning

confidence: 99%

A practical approach to the diagnosis of mixed epithelial and mesenchymal tumours of the uterus

McCluggage

2016

Modern Pathology

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The current 2014 World Health Organization (WHO) Classification of mixed epithelial and mesenchymal tumours of the uterus includes categories of carcinosarcoma, adenosarcoma, adenofibroma, adenomyoma and atypical polypoid adenomyoma, the last two lesions being composed of an admixture of benign epithelial and mesenchymal elements with a prominent smooth muscle component. In this review, each of these categories of uterine neoplasm is covered with an emphasis on practical tips for the surgical pathologist and new developments. In particular, helpful clues in the distinction between carcinosarcoma and dedifferentiated endometrial carcinoma will be discussed. In addition, salient features to help distinguish between adenofibroma, adenosarcoma, embryonal rhabdomyosarcoma and other mesenchymal neoplasms in the differential diagnosis will be outlined. Finally, a discussion of adenomyoma and its main differential diagnostic considerations will be covered.

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Section: Differential Diagnosismentioning

confidence: 99%

A practical approach to the diagnosis of mixed epithelial and mesenchymal tumours of the uterus

McCluggage

2016

Modern Pathology

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“…21 In this assay, the HPV PCR product is hybridized to the genotype-specific probes immobilized as parallel lines on a nitrocellulose strip. Twenty-five individual HPV genotypes (HPV 6,11,16,18,31,33,34,35,39,40,42,43,44,45, 51, 52, 53, 54, 56, 58, 59, 66, 68, 70, and 74) can be identified simultaneously in a single assay. The hybridization and the color reaction, which results in a purple precipitate, were performed automatically in an AutoLiPA device.…”

Section: Hpv Dna Detection and Typingmentioning

confidence: 99%

Prevalence of Human Papillomavirus DNA in Different Histological Subtypes of Cervical Adenocarcinoma

Pirog

Kleter

Olgac

et al. 2000

The American Journal of Pathology

303

228

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The prevalence of human papilloma virus (HPV) DNA in different histological subtypes of cervical adenocarcinoma and related tumors was examined using formalin-fixed, paraffin-embedded tissue samples from 105 primary cervical adenocarcinomas and adenosquamous carcinomas. Broad-spectrum HPV DNA amplification and genotyping was performed with the SPF10 primer set and line probe assay (LiPA), respectively. HPV DNA was detected in 82 of 90 (91%) mucinous adenocarcinomas, encompassing endocervical, intestinal, and endometrioid histological subtypes, and in nine of nine adenosquamous tumors (100%). HPV DNA was not detected in any nonmucinous adenocarcinomas including clear cell, serous, and mesonephric carcinomas (0/6). The most common viral types detected in adenocarcinoma were HPV 16 (50%) and HPV 18 (40%), followed by HPV 45 (10%), HPV52 (2%), and HPV 35 (1%). Multiple HPV types were detected in 9.7% of the cases. Adenocarcinoma of the cervix (AdCx) accounts for approximately 15% of cervical cancers and has been increasing in incidence during the last few decades, particularly in younger women. 1 The etiology of squamous cell carcinoma of the cervix, the most common type of cervical malignancy, is linked to infection with oncogenic types of human papillomavirus (HPV), but the pathogenesis of AdCx is less well understood. Although HPV DNA is consistently detected in Ͼ90% of squamous cell carcinomas of the cervix, 2 the reported prevalence of HPV DNA in AdCx varies significantly, from 32% to 100%, depending on the detection method used. [3][4][5][6][7][8][9][10][11][12][13]

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“…However, based on the morphological features and immunophenotype, they believe these tumors to represent MA. When taking into consideration the description by McFarland et al, it is reasonable to believe that MA can originate in the uterine corpus in two ways: 1) direct development from the mesonephric remnants of the corpus wall and 2) mesonephric differentiation of a Müllerian adenocarcinoma originating from the endometrium, as proposed by McFarland et al MA typically exhibits a variety of architectural growth patterns, even within the same tumor [13]. Although this admixture of growth patterns is a somewhat characteristic feature and can be useful for diagnosis, it may also result in diagnostic issues and mimicry of other neoplasms.…”

Section: Discussionmentioning

confidence: 98%

“…Few cases of MA have been reported in the uterine corpus [2][3][4][5][6][7][8][9][10]. A unique histologic pattern of uniform small tubules containing intraluminal hyaline material is reminiscent of mesonephric remnants [13]. The remnants are sometimes found within the lateral wall of the cervix, mesoovaries, or broad ligaments.…”

Section: Discussionmentioning

confidence: 99%

Mesonephric adenocarcinoma of the uterine corpus with intracystic growth completely confined to the myometrium: a case report and literature review

et al. 2017

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Background: Mesonephric adenocarcinoma (MA) is a rare tumor believed to arise from mesonephric remnants occurring mostly in the uterine cervix and, to a lesser extent, the corpus. Since the first case report of MA in the corpus in 1995, only 16 cases have been reported in the English literature. A recent report suggested that MA originates in Müllerian tissue and exhibits the mesonephric differentiation phenotype. Case presentation: An asymptomatic 61-year-old woman was referred to our hospital because of elevated levels of tumor markers. Imaging revealed an intramural lesion of the uterine corpus exhibiting fluorodeoxyglucose uptake. A total hysterectomy and bilateral salpingo-oophorectomy were performed. The tumor was completely confined to the corpus wall and was composed of an intracystic bulky component and an invasive component in the myometrial layer. The tumor exhibited a variety of growth patterns, including a characteristic tubular pattern with dense eosinophilic secretion reminiscent of the thyroid, as well as a variety of morphologies, such as acinar, papillary, and ductal structures. The structures were immunoreactive for CK7, vimentin, CD10, calretinin, PAX8, and GATA3 and almost completely negative for ER/PgR. CA125 and CA19-9 antigen expression was also detected. Conclusion: A case of MA with a unique growth pattern of an intracystic mass within the corpus wall is presented. The histogenesis and differential diagnoses are discussed. The histogenesis of MA is not yet clear. We hypothesize two different pathways involved: 1) direct development from the mesonephric remnants and/or 2) mesonephric transformation of Müllerian adenocarcinoma.

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A Report of Eight Cases, Including Four with a Malignant Spindle Cell Component

Cited by 154 publications

References 0 publications

A practical approach to the diagnosis of mixed epithelial and mesenchymal tumours of the uterus

A practical approach to the diagnosis of mixed epithelial and mesenchymal tumours of the uterus

Prevalence of Human Papillomavirus DNA in Different Histological Subtypes of Cervical Adenocarcinoma

Mesonephric adenocarcinoma of the uterine corpus with intracystic growth completely confined to the myometrium: a case report and literature review

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