A Report of Clozapine† - Induced Agranulocytosis in the United States

Lieberman, Jeffrey A.; Alvir, José

doi:10.2165/00002018-199200071-00003

Cited by 43 publications

(14 citation statements)

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“…117,121,124 Ten studies related to the incidence of blood dyscrasias such as agranulocytosis and leucopenia. [125][126][127][128][129][130][131][132][133][134] One was a study of NMS, 135 another of venous thromboembolic complications that occurred during clozapine treatment. 136 Five were studies of epilepsy or seizure rates 122,[137][138][139][140] …”

Section: Rare or Long-term Eventsmentioning

confidence: 99%

A systematic review of atypical antipsychotic drugs in schizophrenia

Bagnall

Jones

Ginnelly

et al. 2003

Health Technol Assess

151

114

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Section: Rare or Long-term Eventsmentioning

confidence: 99%

A systematic review of atypical antipsychotic drugs in schizophrenia

Bagnall

Jones

Ginnelly

et al. 2003

Health Technol Assess

151

114

View full text Add to dashboard Cite

show abstract

“…Because of its potentially life-threatening implications, bone marrow toxicity is the most important side effect that restricts the application of clozapine. In approximately 3% of patients treated with clozapine, it results in granulocytopenia, and in approximately 0.6% in agranulocytosis (Alvir et al, 1993;Lieberman and Alvir, 1992;Atkin et al, 1996). The mechanisms of bone marrow toxicity from clozapine are still under debate.…”

Section: Discussionmentioning

confidence: 99%

Clozapine-induced agranulocytosis and thrombopenia in a patient with dopaminergic psychosis

Rudolf

Grond

Neveling

et al. 1997

J. Neural Transmission

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In patients with Parkinson' disease and dopaminergic psychosis, clozapine treatment is recommended as the drug is free from extrapyramidal side effects and does not worsen motor symptoms of the underlying disease. The use of clozapine, however, is limited due to its hematotoxic side effects. For treatment of clozapine-induced agranulocytosis, granulocyte colony-stimulating factors (G-CSF) are recommended. We report the case of a 72-years-old male patient with clozapine-induced agranulocytosis and thrombopenia. Neutropenia was successfully treated with G-CSF, but thrombopenia persisted and resolved spontaneously after 14 days. Bone marrow toxicity of clozapine is not restricted to white cell maturation, but may also impair thrombocytopoesis.

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“…However, the risks of granulocytopenia and agranulocytosis are substantial deterrents to the use of clozapine (Lieberman and Alvir 1992). The necessity of weekly blood counts can be a hindrance in the prescription of clozapine, especially in adolescents.…”

Section: Discussionmentioning

confidence: 99%

Clozapine for Adolescents with Psychosis: Literature Review and Two Case Reports

Mandoki¹

1993

Journal of Child and Adolescent Psychopharmacology

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Like adults, children are genetically predisposed toward developing schizophrenia (McGue 1992). Approximately 10% of parents of children and adolescents with schizophrenia exhibit the disorder (Kallman and Prugh 1971, Kolvin 1971). Pairwise concordance rate for schizophrenia was found to be 28% for monozygotic and 6% fordizygotic twins (Torrey 1992). It has also been shown that stressful life events may precipitate a psychotic episode in children (Birley and Brown 1970).

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A Report of Clozapine† - Induced Agranulocytosis in the United States

Cited by 43 publications

References 0 publications

A systematic review of atypical antipsychotic drugs in schizophrenia

A systematic review of atypical antipsychotic drugs in schizophrenia

Clozapine-induced agranulocytosis and thrombopenia in a patient with dopaminergic psychosis

Clozapine for Adolescents with Psychosis: Literature Review and Two Case Reports

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