A replicative recombinant HPV16 E7 expression virus upregulates CD36 in C33A cells
Yunting Shao,
Peng Wang,
Yunji Zheng
et al.
Abstract:ObjectiveIn past decades, the role of high-risk HPV (HR-HPV) infection in cancer pathogenesis has been extensively studied. The viral E7 protein expressed in pre-malignant cells has been identified as an ideal target for immunological intervention. However, the cultivation of HPV in vitro remains a significant challenge, as well as the lack of methods for expressing the HPV E7 protein and generating replication-competent recombinant viral particles, which posed a major obstacle to further exploration of the fu… Show more
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