A replication study of 19 GWAS-validated type 2 diabetes at-risk variants in the Lebanese population

Almawi, Wassim Y.; Nemr, Rita; Keleshian, Sose H.; Echtay, Akram; Saldanha, Fabiola Lisa; AlDoseri, Fatima A.; Racoubian, Eddie

doi:10.1016/j.diabres.2013.09.001

Cited by 39 publications

(32 citation statements)

References 29 publications

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“…The association of rs2237892 polymorphism and rising T2DM incident risk proved former study result [2,4,[7][8][9][11][12][13][14][15][16][17][21][22][23][24]27,[29][30][31]36,[39][40][41][42][43][44][45][46]. East Asian, Southeast Asian and other region`s subgroup analysis also show the association still stable（OR=1.…”

Section: Main Discoversmentioning

confidence: 82%

Association Between KCNQ1 Gene Polymorphism and Type 2 Diabetes Mellitus: Evidence from Meta-analysis

Qin¹,

Dong²,

Jiang³

et al. 2018

dtbh

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Abstract.A meta-analysis is performed by Stata software for evaluating the relationship between rs2237892， rs2237895 polymorphism in KCNQ1 and type2 diabetes mellitus(T2DM). The Forest plot is estimate the association between T2DM and KCNQ1 Gene polymorphism, and the heterogeneity, Funnel plot as well as Egger's regression tests for publishing bias are assessed through Stata12.0 software. In our meta-analysis, there are 40 articles related rs2237892 included, 61757 T2DM patients and 59078 controls involved; 21 articles on rs2237985 is selected, including 42594 T2DM patients and 45306 controls. The distribution frequency of C allele of rs2237892 and rs2237895 in T2DM are obvious higher than control, combine OR （95%CI） are 1.29(1.27-1.32) and 1.24(1.22-1.27)， showing remarkable statistical significance (z=24.29, P ＜ 0.001; z=20.14, P ＜ 0.001). The rs2237892 and rs2237895 polymorphism in KCNQ1 would increase risk of T2DM.

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Section: Main Discoversmentioning

confidence: 82%

Association Between KCNQ1 Gene Polymorphism and Type 2 Diabetes Mellitus: Evidence from Meta-analysis

Qin¹,

Dong²,

Jiang³

et al. 2018

dtbh

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“…Previous replication studies examining a total of 29 SNPs in the Lebanese population have identified variants associated with T2DM in COL8A1 , KCNQ1 , ALX4 , HNF1 45 (n = 2071), CDKAL1 50 (n = 1422), and TCF7L2 4647 (n = 1610).…”

Section: Discussionmentioning

confidence: 96%

T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility

Ghassibe-Sabbagh

Haber

Salloum

et al. 2014

Sci Rep

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Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are crucial to the understanding of Type 2 Diabetes Mellitus (T2DM) pathophysiology. We report a GWAS on the genetic basis of T2DM in a 3,286 Lebanese participants. More than 5,000,000 SNPs were directly genotyped or imputed using the 1000 Genomes Project reference panels. We identify genome-wide significant variants in two loci CDKAL1 and TCF7L2, independent of sex, age and BMI, with leading variants rs7766070 (OR = 1.39, P = 4.77 × 10−9) and rs34872471 (OR = 1.35, P = 1.01 × 10−8) respectively. The current study is the first GWAS to find genomic regions implicated in T2DM in the Lebanese population. The results support a central role of CDKAL1 and TCF7L2 in T2DM susceptibility in Southwest Asian populations and provide a plausible component for understanding molecular mechanisms involved in the disease.

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“…To date, no major GWAS for diabetes has been reported for an Arab population. Replication studies conducted in Arabs have given mixed results with some studies showing association of common variants with the disease [89,90], while others showing no association with previously identified genetic variants [91,92]. A metaanalysis by Al-Rubeaan et al [93] showed Arabs and Caucasians to be associated with different gene variants which confer risk to T2D, therefore emphasizing the need for a genome-wide study in the Arab population, instead of relying on a shared genetic heritage.…”

Section: T2d: An Arab Perspectivementioning

confidence: 92%

Genetics, Genomics and Personalized Medicine in Type 2 Diabetes: A Perspective on the Arab Region

Siddiqui

Tyagi

2015

Per. Med.

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Type 2 diabetes (T2D) is a wide-spread, chronic metabolic disorder, affecting millions of people worldwide. The epidemic of diabetes has placed a huge strain on public health, longevity and economy. T2D occurs as a result of both genetic and environmental factors and is heterogeneous in its presentation across individuals. This review gives an overview of the genetic variations identified by genome-wide association studies which predispose individuals to T2D and those which are responsible for variable drug response across patients, and the necessity to adopt a personalized approach to diabetes management. We also include a perspective on diabetes in Arabs, given the high incidence of T2D and consanguineous marriages, and the need to understand associated genetic components in this vulnerable population.

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A replication study of 19 GWAS-validated type 2 diabetes at-risk variants in the Lebanese population

Cited by 39 publications

References 29 publications

Association Between KCNQ1 Gene Polymorphism and Type 2 Diabetes Mellitus: Evidence from Meta-analysis

Association Between KCNQ1 Gene Polymorphism and Type 2 Diabetes Mellitus: Evidence from Meta-analysis

T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility

Genetics, Genomics and Personalized Medicine in Type 2 Diabetes: A Perspective on the Arab Region

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