A repertoire of nanoengineered short peptide-based hydrogels and their applications in biotechnology

Conformation Controlled Hydrogelation of Minimalistic α, γ Hybrid Peptide

“…Among the various supramolecular architectures, canonical peptide-based hydrogels have gained momentum for applications in therapeutics, drug delivery, wound healing, cell adhesion, tissue engineering, etc., because of their porous structure, biodegradability, and biocompatibility with the living systems. − More significantly, across various types of peptide hydrogels, short peptide hydrogels have drawn a lot of interest due to their straightforward synthesis and characterization, lower synthetic costs, tunable properties, and notable biocompatibility and biodegradability. Furthermore, it is quite simple to conjugate diverse functional moieties in the short peptide sequences, which improves the physiochemical properties and functionalities of the resulting hydrogels. − However, certain drawbacks, such as low oral viability and shorter half-lives, hamper their use for long-term in vivo applications. In this context, the scope of designing hydrogel from new peptide sequences can exponentially grow through the incorporation of modified and non-natural amino acids along with 20 natural ones.…”