A repeating modular organization of the microcirculation of cat mesentery

Frasher, Wallace G.; Wayland, Harold

doi:10.1016/0026-2862(72)90017-9

Cited by 68 publications

(14 citation statements)

References 10 publications

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“…For this reason, the high degree of tortuosity is of little benefit in maintaining high tissue oxygen tension. This agrees with the limited O 2 demands of this organ (Frasher and Wayland, 1972).…”

Section: Resultssupporting

confidence: 78%

Microcirculation of left atrial muscle, cerebral cortex and mesentery of the cat. A comparative analysis.

Chang¹,

Yamakawa²,

Nuccio³

et al. 1982

Circulation Research

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By means of transillumination (microtransilluminator and light pipe), comparative analyses were carried out on geometry, topography, and morphometry of microcirculation in the cerebral cortex, left atrial muscle, and mesentery of the cat using computer analysis. In addition, specific types of capillary distribution (concurrent, countercurrent, and asymmetric distribution) in these three organs were ascertained from images visualized on films. These parameters were related to their role in tissue oxygen supply. It was found that mean capillary diameter, mean intercapillary distance, total capillary length, and total capillary surface area differed significantly among the three organs. Differences in mean capillary tortuosity between cerebral cortex and left atrial muscle and between left atrial muscle and mesentery also were significant. Mean capillary tortuosity in mesentery and cerebral cortex was of equal magnitude. In the cerebral cortex, a high degree of tortuosity and asymmetric capillary distribution favor tissue oxygenation. A similar situation exists in left atrial muscle, although some concurrent and countercurrent distribution could be detected. In the mesentery, the combination of high capillary tortuosity and concurrent capillary arrangement is unfavorable for tissue oxygenation. Cirv Res 50: 240-249, 1982 IT IS the function of the capillaries to maintain tissue oxygenation constantly and to respond rapidly to changing oxygen demands (Hall

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Section: Resultssupporting

confidence: 78%

Microcirculation of left atrial muscle, cerebral cortex and mesentery of the cat. A comparative analysis.

Chang¹,

Yamakawa²,

Nuccio³

et al. 1982

Circulation Research

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“…3), are a type of modular organization of microvessels, the latter being described elsewhere (Frascher and Wayland, 1972). The microcircles provide perfect reliability in the regulation of blood supply to minute areas of the cerebral neocortex.…”

Section: Discussionmentioning

confidence: 99%

The Modular Organization of the Pial Arterial System in Phylogeny

Mchedlishvili¹,

Kuridze²

1984

J Cereb Blood Flow Metab

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We have investigated the pial arterial microcircles formed by the consecutive ramifications and anastomoses of minute pial vessels on the surface of the cerebral neocortex in various vertebrate species, representatives of various levels of phylogenic development. We found that the pial arterial microcircles became gradually more complex in the following order: hen < rabbit < cat < dog < monkey. The gradual development of microcircles involves various features in these species: (a) They become formed predominantly of smaller pial arterial branches whose vasomotor activity is much higher as compared with that of the larger ones; (b) each circle occupies a smaller area, and hence the number of circles per surface of neocortex increases; (c) the density of arterial branches feeding the circles increases despite the smaller size of the latter; (d) the number of offshooting precortical and radial arteries penetrating the cortex increases; (e) the areas of neocortex fed by individual radial arteries get gradually smaller. Thus, the development of the pial arterial bed contributes more and more toward precise spatial regulation of an adequate blood supply to increasingly smaller areas of neocortical tissue as we rise toward higher levels in phylogeny.

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“…There are several anastomoses between the arteriole and the single eccentrically located venule (Fig. 2) (74,137). It has been proposed that this countercurrent arrangement of the arterioles and venules in the villi facilitates exchange of O 2 between the arteriolar and venular segments, creating a gradient of pO 2 from base to tip (238).…”

Section: Salient Features Of the Mucosal Microcirculationmentioning

confidence: 99%

The Gastrointestinal Circulation: Physiology and Pathophysiology

Granger

Holm

Kvietys

2015

Comprehensive Physiology

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The gastrointestinal (GI) circulation receives a large fraction of cardiac output and this increases following ingestion of a meal. While blood flow regulation is not the intense phenomenon noted in other vascular beds, the combined responses of blood flow, and capillary oxygen exchange help ensure a level of tissue oxygenation that is commensurate with organ metabolism and function. This is evidenced in the vascular responses of the stomach to increased acid production and in intestine during periods of enhanced nutrient absorption. Complimenting the metabolic vasoregulation is a strong myogenic response that contributes to basal vascular tone and to the responses elicited by changes in intravascular pressure. The GI circulation also contributes to a mucosal defense mechanism that protects against excessive damage to the epithelial lining following ingestion of toxins and/or noxious agents. Profound reductions in GI blood flow are evidenced in certain physiological (strenuous exercise) and pathological (hemorrhage) conditions, while some disease states (e.g., chronic portal hypertension) are associated with a hyperdynamic circulation. The sacrificial nature of GI blood flow is essential for ensuring adequate perfusion of vital organs during periods of whole body stress. The restoration of blood flow (reperfusion) to GI organs following ischemia elicits an exaggerated tissue injury response that reflects the potential of this organ system to generate reactive oxygen species and to mount an inflammatory response. Human and animal studies of inflammatory bowel disease have also revealed a contribution of the vasculature to the initiation and perpetuation of the tissue inflammation and associated injury response.

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A repeating modular organization of the microcirculation of cat mesentery

Cited by 68 publications

References 10 publications

Microcirculation of left atrial muscle, cerebral cortex and mesentery of the cat. A comparative analysis.

Microcirculation of left atrial muscle, cerebral cortex and mesentery of the cat. A comparative analysis.

The Modular Organization of the Pial Arterial System in Phylogeny

The Gastrointestinal Circulation: Physiology and Pathophysiology

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