A renorenal vasoconstrictor reflex induced by acetylcholine

Macfarlane,

doi:10.1152/ajplegacy.1970.218.3.851

Cited by 19 publications

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“…The investigators therefore postulated that additional receptor groups, such as osmo-and chemoreceptors, may exist in the kidney. A similar conclusion was reached by MacFarlane 33 to explain a vasoconstrictor reno-renal reflex. The demonstration of renal chemoreceptors should help in attempting a more complete evaluation of the physiological role of renal receptors, by studying the reflex effects of selective stimulation of the different groups of renal sensory nerve endings.…”

Section: Physiological Rolesupporting

confidence: 79%

Renal chemoreceptors in the rat.

Recordati¹,

Moss

Waselkov³

1978

Circulation Research

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There are afferent nerve fibers responsive to alterations of the kidney's chemical environment in the renal nerves of the rat. In anesthetized, artificially ventilated, male Sprague-Dawley rats, single unit recordings were prepared by dissection of the centrally cut nerves of the right kidney. The stimuli used included occlusion of the renal artery, systemic asphyxia, changes in renal arterial and venous pressures, changes in ureteral pressure, and cyanide infusion. We found a population of sensory nerve fibers whose endings are activated only during markedly impaired renal blood flow (produced by clamping the renal artery, severe hypotension below 40 mm Hg, and prolonged occlusion of the renal vein), and during systemic asphyxia. The same units are not responsive to increases and decreases in systemic arterial pressure (range: 40--190 mm Hg), to ureteral pressure (range: 0--50 mm Hg), or to changes in renal venous pressure. None of the 40 single units studied was spontaneously active; their pattern of activation during renal ischemia always was characterized by trains of impulses. These sensory units have functional properties distinctly different from those of known renal mechanoreceptors. They appear to be a homogeneous group of sensory elements, and we have termed them renal ("R") chemoreceptors. Evidence also is presented which is consistent with the concept that a chemical substance released by or accumulated within the kidney might be the agent activating these chemoreceptors during renal ischemia.

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Section: Physiological Rolesupporting

confidence: 79%

Renal chemoreceptors in the rat.

Recordati¹,

Moss

Waselkov³

1978

Circulation Research

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“…The largest dose infused caused significant decreases in certain parameters in the uninfused side. This could be due to a renorenal vasoconstrictor reflex as shown by MacFarlane (1970) when he infused acetylcholine into the renal artery in dogs.…”

Section: Discussionmentioning

confidence: 98%

Increased urinary kallikrein excretion during prostaglandin E1 infusion in anaesthetized dogs and its relation to natriuresis and diuresis.

Mills¹,

Obika²

1977

The Journal of Physiology

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SUMMARY1. The effect of intra-arterial prostaglandin E1 (PGE1) infusion on urinary kallikrein, sodium, potassium and water excretion was studied in normal anaesthetized dogs.2. Infusion of PGE1 caused a dose-related increase in urinary excretion of kallikrein, sodium, potassium and water as well as an increase in renal blood flow (R.B.F.) and a fall in urinary osmolality and renal vascular resistance.3. The changes occurred in the absence of appreciable changes in inulin clearance (CIN), arterial blood pressure, haematocrit, and plasma sodium and potassium concentrations.4. The increased urinary kallikrein excretion correlated positively with the natriuresis, diuresis and kaliuresis and the increase in renal blood flow, but negatively with the urinary osmolality and renal vascular resistance.5. It is concluded that renal kallikrein is involved in the renal response to arterial infusion of PGE1.

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“…A number of viscerorenal and contralateral renorenal reflexes have been described that could be mediated in part by peripheral pathways within the solar plexus (e.g. Liang, 1971;MacFarlane, 1970;Calareau et al 1978;Francisco, Hoverstein & Dibona, 1980). Traditionally, these reflexes were thought to be spinally mediated.…”

Section: Discussionmentioning

confidence: 99%

A study of renal‐efferent neurones and their neural connexions within cat renal ganglia using intracellular electrodes.

Decktor¹,

Weems²

1981

The Journal of Physiology

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SUMMARY1. Intracellular recordings were made, in vitro, from neurones located within left renal ganglia and left coeliac ganglia of cat solar plexus.2. Forty-three percent of the neurones of the renal ganglia tested were identified by antidromic activation as renal-efferent neurones.3. Electrical stimulation of all nerve trunks emanating from renal ganglia, other than the renal nerves, did not antidromically activate renal ganglia neurones. Neurones not antidromically activated were designated as non-efferent neurones.4. Neurones within the renal ganglia were also characterized as phasic or tonic neurones depending on their pattern of discharge.5. Electrical stimulation of renal nerves produced excitatory synaptic potentials (e.p.s.p.s) in 18 % of the renal-efferent neurones.6. Compound e.p.s.p.s were produced in 5000 of the renal ganglia neurones tested by stimulation of the ipsilateral splanchnic nerves and in 840 of the neurones upon stimulation of the vertebral nerve.7. Synaptic responses demonstrating characteristics typical of those induced by activation of multisynaptic neural pathways were produced upon stimulation of renal and coeliac nerves.8. The results of this study indicate that the electrophysiological properties of renal-efferent neurones vary considerably from neurone to neurone and that these neurones receive synaptic inputs from a variety of preganglionic fibres and possibly from other neurones having their soma located within the solar plexus.

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A renorenal vasoconstrictor reflex induced by acetylcholine

Cited by 19 publications

References 0 publications

Renal chemoreceptors in the rat.

Renal chemoreceptors in the rat.

Increased urinary kallikrein excretion during prostaglandin E1 infusion in anaesthetized dogs and its relation to natriuresis and diuresis.

A study of renal‐efferent neurones and their neural connexions within cat renal ganglia using intracellular electrodes.

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