A renewable electrochemical sensor based on a self-assembled framework of chiral molecules for efficient identification of tryptophan isomers

Biopolymer supported electroanalytical methods for the determination of biomolecules and food additives – a comprehensive perspective

“…Jiang and co-workers reported a self-assembled chiral sensor for the determination of tryptophan enantiomers. 40 They synthesised Cu 2 –β-CD through the connection of Cu 2+ to β-cyclodextrin by adding Cu(NO 3 ) 2 ·3H 2 O to 1 M NaOH containing β-CD and a blue precipitate was observed immediately after the addition. Then, the mixture was continuously stirred for 24 hours at room temperature before being filtered to get rid of the precipitate and ethanol was added to the filtrate.…”

Chiral Materials: Progress, Applications, and Prospects

“…Efficient recognition of tryptophan (Trp) isomers at the self‐assembled interface was achieved using electrochemical methods. [ 343 ] A pair of left‐ and right‐handed polyaniline (defined as S‐PANI and R‐PANI) was synthesized by chemical oxidation of aniline, and high enantioselectivity was obtained due to the formation of efficient chiral nano spaces with a specific nanoribbon morphology and a large number of oxygen‐containing functional groups for S‐PANI with a recognition efficiency of 4.90 ( d ‐Trp) and 4.20 ( l ‐Trp) for R PANI of R PANI with a recognition efficiency of 4.20 ( l ‐Trp) (Figure 36c). [ 344 ] An alfa‐cyclodextrin ( α ‐CD) based chiral sensing device for the electrochemical recognition of tyrosine (Tyr) isomers was constructed (Figure 36d).…”

“…b) Schematic illustration showing the procedures for preparation of Cu 2 -𝛽-CD/NH 2 -CS-MWCNTs GCE, and the possible mechanism of electrochemical recognition for Trp enantiomers. Reproduced with permission [343]. Copyright 2022, Elsevier.…”

Chirality Amplification Over the Morphology Control of the Rod-Coil Molecules with Lateral Methyl Groups

“…This field of research has an extremely important role in promoting the development of life sciences and materials chemistry and has become an important topic in the field of chiral science. Chiral self-assembly can generate various functionalized materials with unique advantages that are widely used in fields of adjuvant therapy, − biomimetic chemistry, − catalysis, − and molecular sensors. − Currently, chiral nanomaterials are becoming the focus of fundamental research and various momentous technology applications due to their unparalleled physico-chemical properties, such as advanced circular dichroism (CD) and circularly polarized luminescence. − Among them, rod-coil molecules have broad application prospects for supramolecular self-assembly owing to their accurate controlling of morphological nanostructures by adjusting molecular parameters such as the volume fraction of rod and coil groups, the cross-sectional area of flexible segments, and introducing lateral groups into rigid or flexible blocks. − However, there are few studies regarding the influence of lateral groups with different positions on supramolecular chirality induction, especially related to the control of supramolecular nanostructures and aggregate morphologies by precisely adjusting the positions of lateral groups. Although individual studies have reported on chirality manipulation of supramolecular self-assemblies, it remains challenging to accurately control the position of lateral groups in rod-coil molecules to induce the chirality of aggregates for asymmetric synthesis and catalysis. − …”