A Reliable Synthesis of 2‐ and 6‐Amino‐β‐cyclodextrin and Permethylated‐β‐cyclodextrin.

Muderawan, I Wayan; Ong, Teng Teng; Lee, Teck Chia; Young, David J.; Ching, Chi Bun; Ng, Siu‐Choon

doi:10.1002/chin.200604189

Cited by 3 publications

(3 citation statements)

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“…Previous tosylation of β-CD has been achieved by the use of p-TsCl but this reaction suffers from low yields [23]. An improved method using Ts 2 O under alkaline conditions [18] was used for this synthesis giving an average yield of above 70%.…”

Section: Resultsmentioning

confidence: 99%

Fluorescent Sensing of Chlorophenols in Water Using an Azo Dye Modified β-Cyclodextrin Polymer

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Krause

Mamba

2011

Sensors

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A water soluble azo dye modified β-cyclodextrin polymer 4 was synthesized and used as a chemosensor for the detection of chlorinated phenols, model chlorinated by-products (CBPs) of water treatment for drinking purposes. The characterization of the intermediates and the azo dye modified β-CD polymer was done by UV/Vis Spectrophotometry, FT-IR and 1H-NMR spectroscopies. The chlorophenols were capable of quenching the fluorescence of the polymer. The polymer showed greater sensitivity towards 2,4-dichlorophenol, with a sensitivity factor of 0.35 compared to 0.05 and 0.12 for phenol and 4-chlorophenol, respectively. The stability constants (Ks) of the pollutants were also determined by the Benesi-Hildebrand method to be 2.104 × 103 M−1 for 2,4-dichlorophenol and 1.120 × 102 M−1 for 4-chlorophenol.

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Section: Resultsmentioning

confidence: 99%

Fluorescent Sensing of Chlorophenols in Water Using an Azo Dye Modified β-Cyclodextrin Polymer

Ncube

Krause

Mamba

2011

Sensors

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“…Sodium hyaluronate (M w = 190,000), paclitaxel (Taxol), 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC), N -hydroxysulfosuccinimide (NHSS), N,N ′-dicyclohexyl-carbodiimide (DCC), 4-dimethylaminopyridine (DMAP), and hyaluronidase were purchased from commercial sources and used as received. Mono-6-deoxyl-6-ethylenediamino-permethyl- β -CD 43 , and 5-(4-carboxyphenyl)-10,15,20-triphenylporphyrin 44 were prepared according to procedures reported. Crude chloroform was stirred with CaH 2 for 1 day and then distilled at room pressure prior to use.…”

Section: Methodsmentioning

confidence: 99%

Polysaccharide-based Noncovalent Assembly for Targeted Delivery of Taxol

Yang

Zhang

Chen

et al. 2016

Sci Rep

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The construction of synthetic straightforward, biocompatible and biodegradable targeted drug delivery system with fluorescent tracking abilities, high anticancer activities and low side effects is still a challenge in the field of biochemistry and material chemistry. In this work, we constructed targeted paclitaxel (Taxol) delivery nanoparticles composed of permethyl-β-cyclodextrin modified hyaluronic acid (HApCD) and porphyrin modified paclitaxel prodrug (PorTaxol), through host-guest and amphiphilic interactions. The obtained nanoparticles (HATXP) were biocompatible and enzymatic biodegradable due to their hydrophilic hyaluronic acid (HA) shell and hydrophobic Taxol core, and exhibited specific targeting internalization into cancer cells via HA receptor mediated endocytosis effects. The cytotoxicity experiments showed that the HATXP exhibited similar anticancer activities to, but much lower side effects than commercial anticancer drug Taxol. The present work would provide a platform for targeted paclitaxel drug delivery and a general protocol for the design of advanced multifunctional nanoscale biomaterials for targeted drug/gene delivery.

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“…Моно [6 А -O-(4-толилсульфонил)]-βциклодекстрин является важнейшим прекурсором для получения монозамещенных в положение 6 производных β-циклодекстрина. Нуклеофильное замещение тозильной группы такими нуклеофильными реагентами, как иодид, азид, тиоацетат, гидроксиламин, алкил-или полиалкиламид приводит к соответствующим монозамещенным производным [1,[2][3][4].…”

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