A reliable sign of papillary carcinoma of the thyroid?

Hapke, Marc R.; Dehner, Louis P.

doi:10.1097/00000478-197902000-00004

Cited by 79 publications

(35 citation statements)

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“…Clear nuclei are found in over 80% of such lesions, intranuclear inclusions in about 80-85%, and nuclear grooves are seen in almost all the cases. 3,4,26,[31][32][33] Mitoses are exceptional in usual papillary carcinoma. Psammoma bodies that represent the 'ghosts' of dead papillae are differentiated from dystrophic calcifications by lamellations.…”

Section: Pathologymentioning

confidence: 99%

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Papillary thyroid carcinoma: an update

2011

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The past two decades have seen numerous developments in the understanding of the origins and biology of papillary thyroid carcinoma. Advances in molecular biology, clinicopathologic studies of new entities, facility with fine-needle aspiration biopsy, and new radiologic imaging techniques have allowed for earlier diagnosis of these tumors. However, these advances have also caused controversies in cytologic and histopathologic diagnoses as well as therapy decisions. This paper will focus on several pathologic aspects of papillary carcinoma, which impact on its biology and prognosis.

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Section: Pathologymentioning

confidence: 99%

“…25 The nuclei of papillary cancer have been described as clear, ground glass, empty, or Orphan Annie eyed. 26,31 These nuclei are larger and more oval than normal follicular nuclei and contain hypodense chromatin. In papillary cancer, these nuclei often overlap one another (Figure 2).…”

Section: Nuclear Features Of Papillary Carcinomamentioning

confidence: 99%

Papillary thyroid carcinoma: an update

2011

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“…A few years ago, it used to be the identification of signs of capsular and/or vascular invasion, whereas nowadays it is 'Whether or not the nuclear characteristics of the neoplastic cells support the diagnosis of PTC.' [1][2][3]7,24,45 The diagnosis of encapsulated FVPTC has probably become the hottest topic in thyroid pathology mainly because of the too-liberal utilization of the PTC nuclear criteria. It should be stressed that this dilemma is restricted to the encapsulated type of FVPTC as the other two types of FVPTCs (such as poorly circumscribed and multinodular/diffuse types) do not usually raise diagnostic problems.…”

Section: Differential Diagnosis Between Minimally Invasive Ftc and Enmentioning

confidence: 99%

“…It should be stressed that this dilemma is restricted to the encapsulated type of FVPTC as the other two types of FVPTCs (such as poorly circumscribed and multinodular/diffuse types) do not usually raise diagnostic problems. 21,24,45 We have been stressing, since 2002, the existence of the aforementioned three types of FVPTCs. 46 These types apparently have different natural histories and display quite different patterns of metastization.…”

Section: Differential Diagnosis Between Minimally Invasive Ftc and Enmentioning

confidence: 99%

Follicular thyroid carcinoma

et al. 2011

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Follicular thyroid carcinoma is being diagnosed less and less frequently despite the increasing incidence of well-differentiated thyroid carcinomas everywhere. This review will discuss the reasons underlying such an observation focusing on the evolution of the morphological and immunohistochemical diagnostic criteria of follicular thyroid tumors. It will address the differential diagnosis between follicular carcinoma and three tumor types-follicular adenoma, follicular variant of papillary carcinoma and poorly differentiated carcinoma-as well as the problems raised by the newly described categories of follicular tumors: follicular tumor of uncertain malignant potential, well-differentiated tumor of uncertain malignant potential and welldifferentiated carcinoma, not otherwise specified. Finally, the prognostic and therapeutic significance of some promising molecular biomarkers will be discussed within the frame of the aforementioned histopathological classification.

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“…Historically, the identification of PC relied on the presence of papillary architecture. The current accepted diagnosis of this entity is based on nuclear features that include optical clearing, elongation, overlapping, micronucleoli, and irregular contours with grooves and pseudoinclusions (2)(3)(4). However, identification of these features remains, at times, controversial, and the distinction of papillary carcinoma from follicular adenoma can be difficult.…”

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Immunohistochemical Diagnosis of Papillary Thyroid Carcinoma

et al. 2001

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In thyroid, the diagnosis of papillary carcinoma (PC) is based on nuclear features; however, identification of these features is inconsistent and controversial. Proposed markers of PC include HBME-1, specific cytokeratins (CK) such as CK19, and ret, the latter reflecting a ret/PTC rearrangement. We applied immunohistochemical stains to determine the diagnostic accuracy of these three markers. . HBME-1 and ret were negative in all NH and FA; some of these exhibited focal CK19 reactivity in areas of degeneration. Half of the FC and AC exhibited HBME-1 staining but no positivity for CK19 or ret. In PC, 20% of cases stained for all three markers. Classical PC had the highest positivity with staining for HBME-1 in 70%, CK19 in 80%, and ret in 78%. FVPC were positive for HBME-1 in 45%, for CK19 in 57%, and for ret in 63%; only 7 FVPC were negative for all three markers. The six IC exhibited 67% staining for HBME-1 and 50% positivity for CK19 and ret. The seven HCC had 29% positivity for HBME-1 and CK19, and 57% positivity for ret. This panel of three immunohistochemical markers provides a useful means of diagnosing PC. Focal CK19 staining may be found in benign lesions, but diffuse positivity is characteristic of PC. HBME-1 positivity indicates malignancy but not papillary differentiation. Only rarely are all three markers negative in PC; this panel therefore provides an objective and reproducible tool for the analysis of difficult thyroid nodules.

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A reliable sign of papillary carcinoma of the thyroid?

Cited by 79 publications

References 0 publications

Papillary thyroid carcinoma: an update

Papillary thyroid carcinoma: an update

Follicular thyroid carcinoma

Immunohistochemical Diagnosis of Papillary Thyroid Carcinoma

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