A reliable method for bonding polydimethylsiloxane (PDMS) to polymethylmethacrylate (PMMA) and its application in micropumps

Abstract

Poly(methyl methacrylate) (PMMA) attracts growing interest in microfluidics research community due to its low cost, high transparency, good mechanical and chemical properties. The more flexible polydimethylsiloxane (PDMS) is well suited for pneumatic actuation. However, PDMS is permeable to gases and absorbs molecules from the sample liquids. Combining PMMA with PDMS would allow a microfluidic device to utilize advantages of both materials. Bonding PMMA to PDMS is a critical step for this hybrid approach. In this paper, we present a simple, fast and reliable technique for bonding PMMA to PDMS. A 25-µm thick adhesive film (ARclear Optically clear adhesive 8154, Adhesive Research, Glen Rock, PA USA) was laminated onto a clean PMMA surface. Subsequently, pre-cured PDMS mixture was spin coated onto the adhesive film. After curing, the adhesive and

A liquid progressive multifocal lens adjusted by the deformation of a non-uniform elastic membrane due to the variation of liquid pressure

“…After the surface treatment by the oxygen plasma, the two treated elastic membranes are placed and their edges are kept together tightly for about 24 h. Then a reliable connection without leakage can be achieved. By using an adhesive film (ARclear® Optically clear adhesive 8154, Adhesive Research, Glen Rock, PA USA), the uniform thickness membrane and the substrate can also bond together tightly [19,20].…”

Cyclic Block Copolymer Microchannel Fabrication and Sealing for Microfluidics Applications

“…Compared with PDMS, thermoplastic is a rigid polymer material that can be shaped or reshaped upon heating above the glass transition temperature (T g ). Myriad thermoplastic materials, such as polycarbonate (PC) [14][15][16], polymethyl methacrylate (PMMA) [17][18][19], cyclic olefin polymers (COPs) [20][21][22][23], polystyrene (PS) [24][25][26], and polyethylene terephthalate (PET) [27,28] have been employed in microfluidics. Among them, COPs have high optical transmissivity, satisfactory solvent and acid and base resistivity, and glass-like properties.…”

Sterilization of PMMA microfluidic chips by various techniques and investigation of material characteristics

“…In the past decade, the application of microfluidic technology has grown rapidly in life sciences [1,2]. Recent developments in microfluidics revealed some functions that is included in synthesis and analysis of chemical and biological materials such as genes and proteins, drug delivery, medical diagnostics, cell culture, understanding cell behavior and cell-handling [3,4].…”

“…Polymethylmethacrylate (PMMA) is commercially the most important member of a range of acrylic materials and used primarily in plastic applications due to excellent mechanical and chemical properties [6]. As PMMA is disposable, biocompatible, transparent, impermeable to air, effective to fabricate and suitable for mass fabrication, it is preferred as a polymeric material in the fabrication of microfluidic devices [2,4] and medical applications [6]. Applications of microfluidic systems based on cell and tissue culture are now emerging as physiologically relevant microenvironments can be fabricated by in vitro cell culture.…”