A release of Ti-ions from nanostructured titanium oxide surfaces

Vrchovecká, Kateřina; Weiser, Adam; Přibyl, Jan; Kuta, Jan; Holzer, Jakub; PávkováGoldbergová, Monika; Sobola, Dinara; Dlouhý, A.

doi:10.1016/j.surfin.2021.101699

Cited by 7 publications

(4 citation statements)

References 25 publications

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“…The release of titanium ions from the material was studied at the time periods, thus showing increased ions released from the nanotubes-modified surfaces (Table 2), caused probably by the increased surface area, as was shown in our previous study. 38 A higher concentration of titanium ions above the surface led to increased ions in the cells (Table 3). However, the viability of the cells (Figure 4B) was not affected by the ion concentration.…”

Section: Discussionmentioning

confidence: 97%

Effect of titanium nanostructured surface on fibroblast behavior

Vrchovecká

Kuta

Uher

et al. 2023

J Biomedical Materials Res

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As the consumption of implants increases, so do the requirements for individual types of implants, for example, improved biocompatibility or longevity. Therefore, the nano-modification of the titanium surface is often chosen. The aim was to characterize the modified surface with a focus on medical applications. The titanium surface was modified by the anodic oxidation method to form nanotubes. Subsequently, the material was characterized and analyzed for medical applications-surface morphology, surface wettability, chemical composition, and release of ions into biological fluids. A human gingival fibroblasts (HGFb) cell line was used in the viability study. A homogeneous layer of nanotubes of defined dimensions was formed on the titanium surface, ensuring the material's biocompatibility-the preparation conditions influence the resulting properties of the nanostructured surface. Nanostructured titanium exhibited more suitable characteristics (e.g., wettability, roughness, ion release) for biological applications than compared to pure titanium. It was possible to understand the behavior of the modified layer on the titanium surface and its effect on cell behavior. Another contribution of this work is the combination of material characterization (ion release) with the study of cytocompatibility (direct contact of cells with metals).

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Section: Discussionmentioning

confidence: 97%

Effect of titanium nanostructured surface on fibroblast behavior

Vrchovecká

Kuta

Uher

et al. 2023

J Biomedical Materials Res

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“…The biological behavior of cells is closely related to surface topography, roughness, hydrophilicity and texture of the respective implant material. [19][20][21] Identical material composition of the plain as well as the 3-D-manufactured TiAl6V4 surfaces point out that the described morphological differences are due to the 3-D-topography. Tolksdorf and co-workers (2020) underlined that fibroblasts need a sort of irregular surface of synthetic or artificial materials for an uncomplicated integration process.…”

Section: Discussionmentioning

confidence: 99%

Impact of topography and added TiN-coating on adult human dermal fibroblasts after seeding on titanium surface in-vitro

Hauschild,

Hardes,

Dudda

et al. 2024

J Biomater Appl

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Complications of transcutaneous osseointegrated prosthetic systems (TOPS) focus on the metal-cutaneous interface at the stoma. Besides pain due to scare tissue as well as undefined neuropathic disorders, there is high evidence that the stoma presents the main risk causing hypergranulation and ascending infection. To restore the cutaneous barrier function in this functional area, soft-tissue on- or in-growth providing a vital and mechanically stable bio-artificial conjunction is considered a promising approach. In this study we assessed viability and proliferation of adult human dermal fibroblasts (HDFa) on modifications of a standard prosthetic titanium surface. Un-coated (TiAl6V4) as well as a titanium-nitrite (TiN) coated additive manufactured porous three-dimensional surface structures (EPORE®) were seeded with HDFa and compared to plain TiAl6V4 and polystyrene surfaces as control. Cell viability and proliferation were assessed at 24 h and 7 days after seeding with a fluorescence-based live-dead assay. Adhesion and cell morphology were analyzed by scanning electron microscopy at the respective measurements. Both EPORE® surface specifications revealed a homogenous cell distribution with flat and spread cell morphology forming filopodia at both measurements. Proliferation and trend to confluence was seen on un-coated EPORE® surfaces with ongoing incubation but appeared substantially lower on the TiN-coated EPORE® specification. While cell viability on both EPORE® specifications was comparable to plain TiAL6V4 and polystyrene controls, cell proliferation and confluence were less pronounced when compared to controls. The EPORE® topography allows for fibroblast adhesion and viability in both standard TiAl6V4 and – to a minor degree - TiN-coated specifications as a proof of principle.

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“…Titanium oxide coatings have been extensively studied due to their demonstrated biocompatibility and excellent osseointegration in dental implants, which can be attributed to the native oxide of Ti-based implants [ 141 , 146 , 147 , 148 ]. However, concerns have arisen regarding the extensive use of Ti-based and TiO 2 materials, including their limited bioactivity, reduced corrosion resistance in media containing F − or Cl − over prolonged periods, and the resulting adverse effects of titanium accumulation on the human body [ 149 , 150 , 151 ]. Reports of allergic reactions and hypersensitivity associated with titanium necessitate research into alternative materials [ 152 , 153 ].…”

Section: Biomaterials In Orthopedicsmentioning

confidence: 99%

Biomaterials as Implants in the Orthopedic Field for Regenerative Medicine: Metal versus Synthetic Polymers

et al. 2023

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Patients suffering bone fractures in different parts of the body require implants that will enable similar function to that of the natural bone that they are replacing. Joint diseases (rheumatoid arthritis and osteoarthritis) also require surgical intervention with implants such as hip and knee joint replacement. Biomaterial implants are utilized to fix fractures or replace parts of the body. For the majority of these implant cases, either metal or polymer biomaterials are chosen in order to have a similar functional capacity to the original bone material. The biomaterials that are employed most often for implants of bone fracture are metals such as stainless steel and titanium, and polymers such as polyethene and polyetheretherketone (PEEK). This review compared metallic and synthetic polymer implant biomaterials that can be employed to secure load-bearing bone fractures due to their ability to withstand the mechanical stresses and strains of the body, with a focus on their classification, properties, and application.

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A release of Ti-ions from nanostructured titanium oxide surfaces

Cited by 7 publications

References 25 publications

Effect of titanium nanostructured surface on fibroblast behavior

Effect of titanium nanostructured surface on fibroblast behavior

Impact of topography and added TiN-coating on adult human dermal fibroblasts after seeding on titanium surface in-vitro

Biomaterials as Implants in the Orthopedic Field for Regenerative Medicine: Metal versus Synthetic Polymers

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