A relationship between mast cells and α-smooth muscle actin-positive cells in the nasal polyps of chronic rhinosinusitis

Nishijima, Itomi; Sanai, Akiko; Yoshihara, Toshio

doi:10.1080/00016480902936919

Cited by 5 publications

(2 citation statements)

References 16 publications

(19 reference statements)

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“…The oedematous regions in both CRS and CRS+NP were found poor in aSMA-positive cells. This finding confirms the observation of Nishijima et al showing that the distribution of aSMA-positive cells tended to be more remarkable in pedicle areas than in central and more oedematous areas (37) .…”

Section: C Connective Tissue Chronic Rhinosinusitis With Nasal Po-supporting

confidence: 92%

Different types of tissue composition in inflammatory or reparative upper airway disorders

Coster¹,

Eloy²,

Ferdinande³

et al. 2012

Rhin

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Background: Composition changes of extracellular matrix (ECM) can lead to functional disorders of the upper airways (UA). The aim of this study was to systematically measure both the association patterns and the correlation degree between tissue composition parameters in UA inflammatory diseases. Methodology: Nasal samples were obtained from patients with chronic rhinosinusitis with (CRS+NP), without nasal polyps (CRS), with post-operative adhesions (S) and normal nasal mucosa (NM). A reproducible semi-quantitative method, which takes epithelial and lamina propria damages into account was applied for haematoxylin and eosin, alpha-smooth muscle actin, reticulin, elastin, laminin and collagen type IV stainings. Results: The most severe cases of epithelial shedding have been found in a significant higher amount in CRS+NP when compared with NM. The most severe cases of inflammatory reaction were mainly found in CRS+NP. CRS+NP had significantly more severe cases of oedema than NM. Excluding elastin, networks in other ECM proteins were found modified in fibrotic fields but to a lesser extend in oedematous regions in all conditions. Conclusion: Although non specific, oedema in the lamina propria is a key-feature of CRS+NP, while fibrosis, massively present in CRS and S, affects profoundly the distribution of ECM proteins in these areas.

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Section: C Connective Tissue Chronic Rhinosinusitis With Nasal Po-supporting

confidence: 92%

Different types of tissue composition in inflammatory or reparative upper airway disorders

Coster¹,

Eloy²,

Ferdinande³

et al. 2012

Rhin

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show abstract

“…Increasing evidence points to the role of mast cells in many diseases characterized by chronic injury and repair and a resulting interplay between mast cells and fibroblasts. 39,40 Microarray analysis of NES-NP demonstrated increased expression of hypoxia-inducible factor (HIF) 1a. 41 This is consistent with the concept that occlusion of sinus ostia is a likely primary pathogenic mechanism in this form of CS and will lead to the development of relatively high levels of hypoxia within the sinuses.…”

Section: Noneosinophilic Sinusitismentioning

confidence: 99%