A regulatory CD9<sup>+</sup>B-cell subset inhibits HDM-induced allergic airway inflammation

Braza, Faouzi; Chesné, Julie; Durand, M.; Dirou, S.; Brosseau, Carole; Mahay, Guillaume; Cheminant, Marie‐Aude; Magnan, A.; Brouard, Sophie

doi:10.1111/all.12697

Cited by 68 publications

(64 citation statements)

References 42 publications

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“…Mouse models of allergic airway inflammation have also delineated the important immunoregulatory role played by IL‐10‐producing Bregs. It has been demonstrated by adoptive transfer experiments that CD9 + B cells were able to suppress Th2 and Th17‐mediated airway inflammation by mechanisms dependent on IL‐10 . TGF‐β‐producing B cells may also contribute to allergen tolerance as demonstrated in mouse models of allergic airway inflammation.…”

Section: The Role Of Regulatory B Cells In Allergic Diseasesmentioning

confidence: 99%

Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells

Palomares

Akdiş

Martín‐Fontecha

2017

Immunological Reviews

253

300

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Allergy is a major public health problem with a high socio-economic impact. The number of allergic patients is expected to reach to four billion within two decades when the World's population reaches to 10 billion. Our knowledge on the molecular mechanisms underlying allergic diseases and allergen tolerance induction had significant advances during the last years. Nowadays, it is well accepted that the generation and maintenance of allergen-specific regulatory T cells (Tregs) and regulatory B cells (Bregs) and the involvement of their suppressive cytokines and surface molecules are essential for the induction of allergen tolerance. These mechanisms play essential roles for the restoration of healthy immune responses to allergens in allergen-specific immunotherapy (AIT) and healthy immune response during high-dose antigen exposure in beekeepers and cat owners. AIT remains as the only disease-modifying and curative treatment for allergic diseases and represents a perfect model to investigate the antigen-specific immune responses in humans. A large number of clinical trials demonstrated AIT as an effective treatment in many patients, but it still faces several drawbacks in relation to efficacy, safety, long duration, and patient adherence. Novel strategies to overcome these inconveniences, such as the development of novel adjuvants and alternative routes of administration are being developed. The better understanding of the molecular mechanism governing the generation of Treg and Breg cells during allergen tolerance might well open new avenues for alternative therapeutic interventions in allergic diseases and help better understanding of other immune-tolerance-related diseases.

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Section: The Role Of Regulatory B Cells In Allergic Diseasesmentioning

confidence: 99%

Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells

Palomares

Akdiş

Martín‐Fontecha

2017

Immunological Reviews

253

300

View full text Add to dashboard Cite

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“…Further, B-cells produce IgG4 antibodies, which bind to the allergens without initiating a reaction, thus acting as “blocking antibodies” (20). In a recent study, the authors showed that Bregs were less prevalent in lungs of mice after allergen exposure confirming that the development of asthma alters the homeostasis of IL-10+ regulatory B cells, emphasize the importance of B cells in asthma, not only as IgE producers but also as suppressive cells able to constrain the pathological process (21). Additionally, Tregs cells suppress allergic responses directly and indirectly.…”

Section: Mechanisms Of Immunotherapy To Aeroallergensmentioning

confidence: 92%

Subcutaneous and Sublingual Immunotherapy in Allergic Asthma in Children

Tsabouri

Mavroudi

Feketea³

et al. 2017

Front. Pediatr.

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This review presents up-to-date understanding of immunotherapy in the treatment of children with allergic asthma. The principal types of allergen immunotherapy (AIT) are subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT). Both of them are indicated for patients with allergic rhinitis and/or asthma, who have evidence of clinically relevant allergen-specific IgE, and significant symptoms despite reasonable avoidance measures and/or maximal medical therapy. Studies have shown a significant decrease in asthma symptom scores and in the use of rescue medication, and a preventive effect on asthma onset. Although the safety profile of SLIT appears to be better than SCIT, the results of some studies and meta-analyses suggest that the efficacy of SCIT is better and that SCIT has an earlier onset than SLIT in children with allergic asthma. Severe, not controlled asthma, and medical error were the most frequent causes of SCIT-induced adverse events.

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“…Deeper analysis of the Breg phenotype has revealed that CD9 is a specific marker for Breg cells in mice and humans [30,31]. In humans, the expression of CD9 is increased dramatically at the surface of CD24 hi CD38…”

Section: Cd27mentioning

confidence: 99%

“…Recently, Braza et al [30] showed that this new regulatory B-cell subset, CD9 + Breg cells, inhibits house dust mite-induced allergic airway inflammation. Initially, the authors showed that the induction of allergic asthma alters the homeostasis of IL-10 + Breg cells, thus increasing production of inflammatory cytokines by B cells.…”

Section: Cd27mentioning

confidence: 99%

Regulatory B Cells and Allergy: Uncovering the Link

Mota¹,

Martins²,

Borrego³

2017

J Investig Allergol Clin Immunol

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Regulatory B (Breg) cells are recognized as immunosuppressive cells. During the last few years, several subsets of Breg cells with different phenotypes and suppressive mechanisms have been described in the literature. We review the role of Breg cells in allergy based on an extensive literature search in PubMed. We describe the types and mechanisms of action of B cells and their role in the pathogenesis of several allergic diseases (allergic asthma, allergic rhinitis, food allergy, contact hypersensitivity, and anaphylaxis). ResumenLos linfocitos reguladores del tipo B (B reg.) juegan un papel importante en el funcionamiento del sistema inmunitario. Durante los últimos años, se han descrito varios subgrupos de linfocitos B reg., con diferentes fenotipos y mecanismos supresores. Nuestro objetivo es recopilar la información existente sobre el papel de los linfocitos B reg. en Alergología, en base a una profunda investigación bibliográfica en PubMed. Describimos los tipos y mecanismos de acción de los linfocitos B y su función en la patogénesis de varias enfermedades alérgicas (asma alérgica, rinitis alérgica, alergia alimentaria, eccema de contacto y anafilaxia). Palabras clave: Linfocitos B reguladores. Alergia. Enfermedad alérgica. Tolerancia a alérgenos. B10. Br1. Asma. Alergia alimentaria. Alergia al veneno de himenópteros. Embarazo.

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A regulatory CD9⁺B-cell subset inhibits HDM-induced allergic airway inflammation

Abstract: This finding strengthens the potential for Breg-targeted therapies in allergic asthma.

Cited by 68 publications

References 42 publications

Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells

Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells

Subcutaneous and Sublingual Immunotherapy in Allergic Asthma in Children

Regulatory B Cells and Allergy: Uncovering the Link

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A regulatory CD9+B-cell subset inhibits HDM-induced allergic airway inflammation

Abstract: This finding strengthens the potential for Breg-targeted therapies in allergic asthma.

Cited by 68 publications

References 42 publications

Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells

Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells

Subcutaneous and Sublingual Immunotherapy in Allergic Asthma in Children

Regulatory B Cells and Allergy: Uncovering the Link

Contact Info

Product

Resources

About

A regulatory CD9⁺B-cell subset inhibits HDM-induced allergic airway inflammation