A registry-based study of non-Aspergillus mould infections in recipients of allogeneic haematopoietic cell transplantation

Fox, Laura; Barba, Pere; Heras, Inmaculada; López-Parra, Miriam; González‐Vicent, Marta; Cámara, Rafael de la; Batlle, Montserrat; Parody, Rocío; Vallejo, Carlos; Ruiz‐Camps, Isabel; Vázquez, Lourdes

doi:10.1016/j.cmi.2014.08.006

Cited by 43 publications

(68 citation statements)

References 5 publications

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“…However, since none of them presented DRM to RT inhibitors, the high VL observed in the last available determination in three patients with known viremia would suggest bad adherence to treatment. The high rate of DRM to all drug classes among the 64 patients with available resistance data during LPV/r treatment is in agreement with the long history of therapy, frequent regimen switches and drug experience, and high off-labels ARV exposure, as previously reported [24, 28,37,38]. Some limitations to the study are the relatively late initiation of LPV/r in this cohort (9.5 years), the high rate of patients including LPV/r as at least third line treatment (with severe failure background), the high evolution of ARV options in children and adolescents during the study period and the late formal approval of LPV/r use in children.…”

Section: Discussionsupporting

confidence: 87%

Impact of lopinavir-ritonavir exposure in HIV-1 infected children and adolescents in Madrid, Spain during 2000-2014

et al. 2017

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BackgroundThe most-used protease-inhibitor in children is Lopinavir-ritonavir (LPV/r), which provides durable suppression of viral load and increases CD4+T-counts. This study describes the virological outcome of the HIV-1-infected paediatric population exposed to LPV/r during 15 years in Spain.MethodologyPatients from the Madrid Cohort of HIV-1-infected-children and adolescents exposed to LPV/r as different line therapy during 2000–2014 were selected. The baseline epidemiological-clinical features, viral suppression, changes in CD4+T-CD8+T cell counts and drug susceptibility were recorded before and during LPV/r exposure. Drug resistance mutations (DRM) were identified in viruses from samples collected until 2011. We predicted drug susceptibility to 19 antiretrovirals among those carrying DRM using the Stanford′s HIVdb Algorithm.ResultsA total of 199 (37.3%) of the 534 patients from the cohort were exposed to LPV/r during 2000–2014 in first (group 1), second (group 2) or more line-therapies (group 3). Patients were mainly Spaniards (81.9%), perinatally infected (96.5%) with subtype-B (65.3%) and HIV-diagnosed before year 2000 (67.8%). The mean age at first LPV/r exposure was 9.7 years. After protease-inhibitor exposure, viral suppression was higher in groups 1 and 2 than in group 3. Viral suppression occurred in 87.5%, 68.6% and 64.8% patients from groups 1, 2 and 3, respectively. Among the 64 patients with available resistance data during LPV/r treatment, 27(42.3%) carried DRM to protease-inhibitor, 28 (58.3%) to reverse-transcriptase-inhibitors and 21 (43.7%) to non-reverse-transcriptase-inhibitors. Darunavir/ritonavir, atazanavir-ritonavir and tipranavir/ritonavir presented the highest susceptibility and nelfinavir the lowest.ConclusionsA better lymphocyte recovering occurred when protease-inhibitor was taken as part of a first-line regimen and a higher number of patients reached viral suppression. The least compromised antiretrovirals for rescue antiretroviral regimens, according to DRM in the LPV/r-exposed-paediatric cohort, were mainly the new protease inhibitors.

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Section: Discussionsupporting

confidence: 87%

Impact of lopinavir-ritonavir exposure in HIV-1 infected children and adolescents in Madrid, Spain during 2000-2014

et al. 2017

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“…Rickettsiales are associated with a wide range of animals including diverse arthropods, mammals and birds3614151617181920. High levels of genetic diversity in Rickettsiales have been identified in both ticks and vertebrates61436, including multiple infection by distinct bacteria in a single tick species1837.…”

Section: Discussionmentioning

confidence: 99%

“…The global incidence and geographic range of rickettsial diseases is seemingly experiencing its second pronounced increase in the last 40 years67, and the incidence of human monocytotropic ehrlichiosis (HME) and human granulocytic anaplasmosis (HGA) have increased steadily since their discovery in the 1980s and 1990s, respectively811. Due to better diagnostic techniques and enhanced surveillance, the identification of new Rickettsiales and/or their associated diseases has increased markedly over the last 10 years712131415, and bacteria that had previously been considered nonpathogenic to humans are now associated with disease67141516. Clearly, Rickettsiales will present a considerable public health challenge for the forseeable future.…”

mentioning

confidence: 99%

Extensive genetic diversity of Rickettsiales bacteria in multiple mosquito species

Guo

Tian

Lin³

et al. 2016

Sci Rep

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Rickettsiales are important zoonotic pathogens, causing severe disease in humans globally. Although mosquitoes are an important vector for diverse pathogens, with the exception of members of the genus Wolbachia little is known about their role in the transmission of Rickettsiales. Herein, Rickettsiales were identified by PCR in five species of mosquitoes (Anopheles sinensis, Armigeres subalbatus, Aedes albopictus, Culex quinquefasciatus and Cu. tritaeniorhynchus) collected from three Chinese provinces during 2014–2015. Subsequent phylogenetic analyses of the rrs, groEL and gltA genes revealed the presence of Anaplasma, Ehrlichia, Candidatus Neoehrlichia, and Rickettsia bacteria in mosquitoes, comprising nine documented and five tentative species bacteria, as well as three symbionts/endosybionts. In addition, bacteria were identified in mosquito eggs, larvae, and pupae sampled from aquatic environments. Hence, these data suggest that Rickettsiales circulate widely in mosquitoes in nature. Also of note was that Ehrlichia and Rickettsia bacteria were detected in each life stage of laboratory cultured mosquitoes, suggesting that Rickettsiales may be maintained in mosquitoes through both transstadial and transovarial transmission. In sum, these data indicate that mosquitoes may have played an important role in the transmission and evolution of Rickettsiales in nature.

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“…Although the functional activity of CB2R in AERD is not within the scope of this pilot investigation, a nonsense CB2R Q63R single-nucleotide polymorphism has been previously described and associated with advanced cirrhosis among patients with viral hepatitis. 17,18 Additional study is necessary to evaluate native CB2R function, relative amounts of eCA ligands, and the prevalence of inactivating polymorphisms in AERD.…”

Section: Discussionmentioning

confidence: 99%

Endocannabinoid receptor CB2R is significantly expressed in aspirin‐exacerbated respiratory disease: a pilot study

Corrado

Battle

Wise

et al. 2018

Int Forum Allergy Rhinol

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A registry-based study of non-Aspergillus mould infections in recipients of allogeneic haematopoietic cell transplantation

Cited by 43 publications

References 5 publications

Impact of lopinavir-ritonavir exposure in HIV-1 infected children and adolescents in Madrid, Spain during 2000-2014

Impact of lopinavir-ritonavir exposure in HIV-1 infected children and adolescents in Madrid, Spain during 2000-2014

Extensive genetic diversity of Rickettsiales bacteria in multiple mosquito species

Endocannabinoid receptor CB2R is significantly expressed in aspirin‐exacerbated respiratory disease: a pilot study

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