A regiospecific three-component one-step cyclocondensation to 6-cyano-5,8-dihydropyrido[2,3-d]pyrimidin-4(3H)-ones. Using microwaves under solvent-free conditions

Three‐component, one‐pot synthesis of pyrimido[4,5‐b]‐quinoline and pyrido[2,3‐d]pyrimidine derivatives

“…So, single crystal X-ray structure determination which failed to have it would be an additional tool to confirm the structure of some of the newly prepared dihydropyrido-and pyrido [2,3-d]pyrimidine derivatives. The recent results of Elgemeie et al [29] and others [30][31][32][33] represent an additional support for the linear structure.…”

Crystal structure of (E)-2-(benzo[d]thiazol-2-yl)-3-(pyridin-3-yl)acrylonitrile)

“…In addition, this family of compounds have been proved for having prominent biological properties as antifungal, antitumor, and antibacterial activities [3][4][5][6][7], as well as applications for the design of dendrimers [8] and uorescent probes for visualizing endogenous thiols in living cells [9,10]. They have also been reported in the literature as versatile building-blocks for molecules with potential biological or pharmaceutical applications [11][12][13][14][15][16][17].…”

Convenient Selective Synthesis of Substituted Pyrido[2,3-d]pyrimidones and Annulated Derivatives

“…Infrared spectra measured using KBr discs on a Mattson 5000 FTIR spectrometer. 1 H NMR data were obtained in CDCl 3 or DMSO solution on a Varian XL 200 MHz instrument using TMS as internal standard. Chemical shifts are reported in ppm (δ ) downfield from internal TMS.…”

“…Recently, Quiroga [2] has reported the selective preparation of a number of condensed heterocycles as potential biologically active compounds. Amongst these, pyrido [2,3-d]pyrimidine derivatives known as deazalumazines [3,4] present interesting biological properties. These compounds have been used as dihydrofolate reductase inhibitors and antitumor agents [5 -9]; some of them have shown a broad spectrum of antimicrobial activity [10 -13], diuretic properties [14] and activity against platelet aggregation [15].…”