A regioselective synthesis of 3,4-diaryl-1H-pyrazoles through a 1,3-dipolar cycloaddition of tosylhydrazones and nitroalkenes

Abstract

A procedure for the selective synthesis of 3,4-diaryl-1H-pyrazoles through a 1,3-dipolar cycloaddition is reported. The transformation occurred under mild conditions using affordable tosylhydrazones and nitroalkenes commencing from benzaldehydes/heteroaromatic aldehydes as...

Metal‐Free [2+3] Dipolar Cycloaddition/Denitration Cascade between Nitroalkenes and α‐Diazoesters: Regioselective Access to Functionalized NH−Pyrazoles

“…[16] Nitroalkenes are easily accessible versatile synthetic motifs for the swift generation of molecular complexity. [17] Given the inherent synthetic tunability of βnitroalkenes towards the construction of functional heterocycles, [18] we envisioned to exploit its reactivity with αdiazoesters. In recent years, α-diazoesters a metal-free reagent has been widely used in numerous reactions owing to its ready availability, inexpensiveness and mild nature to access nitrogen-containing functional molecules.…”