A region-based two-step P300-based brain–computer interface for patients with amyotrophic lateral sclerosis

Ikegami, Shiro; Takano, Kouji; Kondo, Kiyohiko; Saeki, Naokatsu; Kansaku, Kenji

doi:10.1016/j.clinph.2014.03.013

Cited by 30 publications

(30 citation statements)

References 48 publications

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“…We previously reported that patients with late-stage ALS, who could not use a conventional row/column matrix P300 speller well, could operate a region-based, two-step speller that had a larger flashing area than the conventional visual array (Ikegami et al, 2014). Patients with late-stage ALS also showed various oculomotor impairments, such as dysfunction in smooth pursuit and slowing fixation (Nijboer et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…The experimental conditions were based on our previous study (Ikegami et al, 2014). The P300 speller used the P300 paradigm and involved the presentation of a selection of icons arranged in a matrix.…”

Section: Methodsmentioning

confidence: 99%

“…The conventional P300 speller uses a 6 × 6 matrix of icons consisting of 26 English alphabets and 10 numeric characters or symbols (Farwell and Donchin, 1988). In this study, we used a region-based, two-step P300-based spelling paradigm with green/blue flickers to elicit the P300 response to a target stimulus (Takano et al, 2009, Ikegami et al, 2014). This system had a 6 × 9 matrix, and all matrices had 48 hiragana characters and six symbols in total.…”

Section: Methodsmentioning

confidence: 99%

“…Several research groups have reported clinical experiments in patients with ALS, and reliable performance has been reported (Piccione et al, 2006; Sellers and Donchin, 2006; Hoffmann et al, 2008, Nijboer et al, 2008, Silvoni et al, 2009, McCane et al, 2015). Our research group developed a region-based, two-step P300 speller, which has a larger flashing area than the conventional visual array, and showed that the two-step procedure provided significantly increased accuracy when compared with a conventional row/column speller for patients with ALS (Ikegami et al, 2014). The two-step procedure may also be useful for other patients with neurodegenerative diseases who are potential users of the BCI speller.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Operation of a P300-based brain-computer interface by patients with spinocerebellar ataxia

Okahara

Takano

Komori

et al. 2017

Clinical Neurophysiology Practice

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Operation of a P300-based brain-computer interface by patients with spinocerebellar ataxia

Okahara

Takano

Komori

et al. 2017

Clinical Neurophysiology Practice

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“…While most P300-based BCIs have been studied mainly in healthy volunteers (HVs), their usage has been explored in small numbers of people with ALS or other severe neuromuscular disabilities (Escolano et al, 2010, Hoffmann et al, 2008, Ikegami et al, 2014, Kaufmann et al, 2013a, Kubler and Birbaumer, 2008, Kubler et al, 2009, Manyakov et al, 2011, McFarland et al, 2011, Nijboer et al, 2008, Pires et al, 2011, Pires et al, 2012, Sellers and Donchin, 2006, Sellers et al, 2010, Silvoni et al, 2009, Spuler et al, 2012, Townsend et al, 2010). Visual problems can occur in people with advanced ALS (e.g.…”

Section: Introductionmentioning

confidence: 99%

P300-based brain-computer interface (BCI) event-related potentials (ERPs): People with amyotrophic lateral sclerosis (ALS) vs. age-matched controls

McCane

Heckman

McFarland

et al. 2015

Clinical Neurophysiology

127

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Objective Brain-computer interfaces (BCIs) aimed at restoring communication to people with severe neuromuscular disabilities often use event-related potentials (ERPs) in scalp-recorded EEG activity. Up to the present, most research and development in this area has been done in the laboratory with young healthy control subjects. In order to facilitate the development of BCI most useful to people with disabilities, the present study set out to: (1) determine whether people with amyotrophic lateral sclerosis (ALS) and healthy, age-matched volunteers (HVs) differ in the speed and accuracy of their ERP-based BCI use; (2) compare the ERP characteristics of these two groups; and (3) identify ERP-related factors that might enable improvement in BCI performance for people with disabilities. Methods Sixteen EEG channels were recorded while people with ALS or healthy age-matched volunteers (HVs) used a P300-based BCI. The subjects with ALS had little or no remaining useful motor control (mean ALS Functional Rating Scale-Revised 9.4(±9.5SD) (range 0–25)). Each subject attended to a target item as the items in a 6×6 visual matrix flashed. The BCI used a stepwise linear discriminant function (SWLDA) to determine the item the user wished to select (i.e., the target item). Offline analyses assessed the latencies, amplitudes, and locations of ERPs to the target and non-target items for people with ALS and age-matched control subjects. Results BCI accuracy and communication rate did not differ significantly between ALS users and HVs. Although ERP morphology was similar for the two groups, their target ERPs differed significantly in the location and amplitude of the late positivity (P300), the amplitude of the early negativity (N200), and the latency of the late negativity (LN). Conclusions The differences in target ERP components between people with ALS and age-matched HVs are consistent with the growing recognition that ALS may affect cortical function. The development of BCIs for use by this population may begin with studies in HVs but also needs to include studies in people with ALS. Their differences in ERP components may affect the selection of electrode montages, and might also affect the selection of presentation parameters (e.g., matrix design, stimulation rate). Significance P300-based BCI performance in people severely disabled by ALS is similar to that of age-matched control subjects. At the same time, their ERP components differ to some degree from those of controls. Attention to these differences could contribute to the development of BCIs useful to those with ALS and possibly to others with severe neuromuscular disabilities.

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Amyotrophic Lateral Sclerosis Disease Progression Presents Difficulties in Brain Computer Interface Use

Dryden

Sahal

Feldman

et al. 2021

Advances in Neuroergonomics and Cognitive Engineering

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A region-based two-step P300-based brain–computer interface for patients with amyotrophic lateral sclerosis

Cited by 30 publications

References 48 publications

Operation of a P300-based brain-computer interface by patients with spinocerebellar ataxia

Operation of a P300-based brain-computer interface by patients with spinocerebellar ataxia

P300-based brain-computer interface (BCI) event-related potentials (ERPs): People with amyotrophic lateral sclerosis (ALS) vs. age-matched controls

Amyotrophic Lateral Sclerosis Disease Progression Presents Difficulties in Brain Computer Interface Use

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