A refractory wound healing hydrogel with integrated functions of photothermal anti-infection, superoxide dismutase mimicking activity, and intelligent infection management

Guo, Chuan; Wang, Yu; Liu, Hui; Wu, Ye; Wang, Yi; Cao, Zhenxing; Li, Weilong; Peng, Yan; Hui, Xiong; Jin, Biqiang; Kong, Qingquan; Wu, Jinrong

doi:10.1016/j.matdes.2022.111280

Cited by 6 publications

(3 citation statements)

References 33 publications

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“…Wound infection is a major clinical challenge, and timely detection of wound tissue environment is the key to effective interventions. , We all know that the wound environment is complex. Therefore, the specificity and sensitivity of the material’s intelligent response need to be guaranteed, which is highly relevant to both the choice of the detectors and the nature of the material itself.…”

Section: Nanofibersmentioning

confidence: 99%

Novel Biomaterials for Wound Healing and Tissue Regeneration

Zhong,

Wei,

et al. 2024

ACS Omega

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Skin is the first defense barrier of the human body, which can resist the invasion of external dust, microorganisms and other pollutants, and ensure that the human body maintains the homeostasis of the internal environment. Once the skin is damaged, the health threat to the human body will increase. Wound repair and the human internal environment are a dynamic process. How to effectively accelerate the healing of wounds without affecting the internal environment of the human body and guarantee that the repaired tissue retains its original function as much as possible has become a research hotspot. With the advancement of technology, researchers have combined new technologies to develop and prepare various types of materials for wound healing. This article will introduce the wound repair materials developed and prepared in recent years from three types: nanofibers, composite hydrogels, and other new materials. The paper aims to provide reference for researchers in related fields to develop and prepare multifunctional materials. This may be helpful to design more ideal materials for clinical application, and then achieve better wound healing and regeneration effects.

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Section: Nanofibersmentioning

confidence: 99%

Novel Biomaterials for Wound Healing and Tissue Regeneration

Zhong,

Wei,

et al. 2024

ACS Omega

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“…Excellent conductivity is the primary consideration for an e-skin product. As the traditional epidermal electrodes, metals exhibit poor adhesion to tissues, high interface impedance, and ineffective electrical communication due to the lack of softness; whereas, the conductive hydrogels, featured skin-like softness, similar structure to the biological tissues, and tunable three-dimensional conductive channels, have attracted more and more research interests in wearable electronics. − In addition, based on the ability to show rapid response to various external stimuli, the conductive hydrogels can be used in the field of medical diagnosis, health management, , human–machine interfaces, , and flexible energy storage systems as well . In particular, the hydrogels that can transform physiological activity signals into detectable electronic signals have drawn widespread attention in recent years, attributing to the huge prospect of flexible electronic skins. − …”

Section: Introductionmentioning

confidence: 99%

Highly Stretchable and Self-Adhesive Wearable Biosensor Based on Nanozyme-Catalyzed Conductive Hydrogels

Xu,

Wang,

Shan

et al. 2024

ACS Appl. Polym. Mater.

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A highly stretchable and self-adhesive wearable biosensor is prepared from nanozyme-catalyzed conductive hydrogels. The hydrogels are first prepared from a nanozyme (Ta–Ag) based on polyphenol (tannic acid, Ta) chelate with metal ions (silver ion, Ag+), which possesses peroxidase (POD)-like activity. After that, a huge number of free radicals are formed by the interaction between the Ta–Ag NPs and ammonium persulfate (APS), which initiate the hydrogel polymerization via a facile “one-pot” compositing strategy without ultraviolet (UV) or thermal treatment. The homogeneous distribution of nanozymes in the interpenetrating network of sodium alginate (SA) and polyacrylamide (PAAm) realizes a dermis-mimicking structure in the flexible conductor, named Ta–Ag–SA/PAAm. It simultaneously improves the mechanical properties and conductivity. Similar to the adhesion of mussels, the nanozymes contain abundant phenolic hydroxyl groups, favoring the adhesiveness of hydrogels. Due to the capability of changing conductivity with the strain, the obtained hydrogels are able to accurately monitor different amplitudes of human activities in real time. In addition, the Ta–Ag nanozyme exhibits a good bacterial adhesion capability and thereby enhances the bactericidal efficiency of Ag. Based on the high performance of sensing and antibacterial activity, the obtained Ta–Ag–SA/PAAm hydrogels can be a promising candidate for a broad range of applications, such as adhesive epidemic biosensors and wearable medical patches.

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“…Conductive hydrogels featuring structural resemblance to biological tissues, tunable three-dimensional porous conductive channels, and rapid response to various external stimuli, have drawn widespread attention as versatile biomimetic skin for applications in health management, 1,2 disease diagnosis, 3 human-machine interfaces, 4,5 implantable devices, 6 and portable energy harvesters. 7 Recently, hydrogel-based wearable biosensors have been developed to detect pathophysiological events of skin wounds for human healthcare beyond the traditional clinical settings.…”

Section: Introductionmentioning

confidence: 99%