A refractory case of chromoblastomycosis due to Fonsecaea monophora with improvement by photodynamic therapy

Yang, Yu-Chih; Hu, Yongxuan; Zhang, Junmin; Li, Xiqing; Liu, Changming; Liang, Yeru; Xi, Liyan

doi:10.3109/13693786.2012.655258

Cited by 39 publications

(30 citation statements)

References 22 publications

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“…The clinical isolate was submitted to antifungal susceptibility testing according to CLSI guidelines (M38-A document) as previously described [3, 10], and the MICS of antifungal combination was according to previously described [3, 10]. Itraconazole (Xian-Janssen Pharmaceutical Ltd. Xi’an, China), terbinafine (Beijing Novartis Pharmaceutical Ltd., Beijing, China) and voriconazole (Sigma, USA) were dissolved in 100 % DMSO as stock solution (3,200 µg/mL).…”

Section: Methodsmentioning

confidence: 99%

“…Usually, it is caused by traumatic inoculation of a specific group of dematiaceous fungi and associated with low cure and high relapse rates [1, 2]. Several species of pathogens are involved in the disease etiology, including Cladophialophora carrionii, Fonsecaea pedrosoi, Fonsecaea monophora, Fonsecaea nubica and Rhinocladiella aquaspersa [3]. In southern China, F. pedrosoi and F. monophora are the most common causes [4], while other fungi, such as F. nubica and Phialophora aquaspersa , are less common [5, 6].…”

Section: Introductionmentioning

confidence: 99%

“…This treatment may be considered an alternative for the management of fungal infections [14]. Antifungal PDT has been successfully employed against Candida species [15], dermatophytes [16], A. fumigatus [17] and F. monophora [3]. …”

Section: Introductionmentioning

confidence: 99%

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Photodynamic Therapy Combined with Terbinafine Against Chromoblastomycosis and the Effect of PDT on Fonsecaea monophora In Vitro

Huang

et al. 2014

Mycopathologia

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Chromoblastomycosis, a chronic fungal infection of skin and subcutaneous tissue caused by dematiaceous fungi, is associated with low cure and high relapse rates. Among all factors affecting clinical outcome, etiological agents have an important position. In southern China, Fonsecaea pedrosoi and Fonsecaea monophora are main causative agents causing Chromoblastomycosis. We treated one case of chromoblastomycosis by photodynamic therapy (PDT) of 5-aminolevulinic acid (ALA) irradiation combined with terbinafine 250 mg a day. The lesions were improved after two sessions of ALA-PDT treatment, each including nine times, at an interval of 1 week, combined with terbinafine 250 mg/day oral, and clinical improvement could be observed. In the following study, based on the clinical treatment, the effect of PDT and antifungal drugs on this isolate was detected in vitro. It showed sensitivity to terbinafine, itraconazole or voriconazole, and PDT inhibited the growth. Both the clinic and experiments in vitro confirm the good outcome of ALA-PDT applied in the inhibition of F. monophora. It demonstrated that combination of antifungal drugs with ALA-PDT arises as a promising alternative method for the treatment of these refractory cases of chromoblastomycosis.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Photodynamic Therapy Combined with Terbinafine Against Chromoblastomycosis and the Effect of PDT on Fonsecaea monophora In Vitro

Huang

et al. 2014

Mycopathologia

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“…Lyon et al reported PDT with a red light-emitting diode (LED) light with a low-cost methylene blue photosensitizer against CBM (283). After 6 PDT sessions, this well-tolerated procedure resulted in substantial improvement and complete remission of the lesions (285). Also, combination therapy with antifungals and PDT has been reported.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Chromoblastomycosis

et al. 2017

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SUMMARY Chromoblastomycosis (CBM), also known as chromomycosis, is one of the most prevalent implantation fungal infections, being the most common of the gamut of mycoses caused by melanized or brown-pigmented fungi. CBM is mainly a tropical or subtropical disease that may affect individuals with certain risk factors around the world. The following characteristics are associated with this disease: (i) traumatic inoculation by implantation from an environmental source, leading to an initial cutaneous lesion at the inoculation site; (ii) chronic and progressive cutaneous and subcutaneous tissular involvement associated with fibrotic and granulomatous reactions associated with microabscesses and often with tissue proliferation; (iii) a nonprotective T helper type 2 (Th2) immune response with ineffective humoral involvement; and (iv) the presence of muriform (sclerotic) cells embedded in the affected tissue. CBM lesions are clinically polymorphic and are commonly misdiagnosed as various other infectious and noninfectious diseases. In its more severe clinical forms, CBM may cause an incapacity for labor due to fibrotic sequelae and also due to a series of clinical complications, and if not recognized at an early stage, this disease can be refractory to antifungal therapy.

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“…It was highly effective in killing the samples of Fonsecaea pedrosoi and Cladophialophora carrionii tested in vitro, and also in treating clinical lesions. 12 On the other hand, Yang et al 13 used ALA-PDT to treat a patient with chromoblastomycosis caused by Fonsecaea monophora, obtaining partial improvement.…”

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confidence: 99%

Cutaneous Sporotrichosis Treated with Photodynamic Therapy: An in Vitro and in Vivo Study

Gilaberte

Aspíroz

Alejandre³

et al. 2014

Photomedicine and Laser Surgery

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Background: Sporotrichosis is a fungal infection caused by Sporothrix schenckii complex, usually restricted to the skin, subcutaneous cellular tissue, and adjacent lymphatic vessels. Antimicrobial photodynamic therapy (aPDT) could be a good alternative to manage localized, superficial infections. Case report: A 65-year-old African woman was diagnosed with a fixed cutaneous sporotrichosis on her left arm, treated with itraconazol and oral terbinafine with partial improvement. Topical 16% methyl aminolevulinate (MAL, Metvix

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A refractory case of chromoblastomycosis due to Fonsecaea monophora with improvement by photodynamic therapy

Cited by 39 publications

References 22 publications

Photodynamic Therapy Combined with Terbinafine Against Chromoblastomycosis and the Effect of PDT on Fonsecaea monophora In Vitro

Photodynamic Therapy Combined with Terbinafine Against Chromoblastomycosis and the Effect of PDT on Fonsecaea monophora In Vitro

Chromoblastomycosis

Cutaneous Sporotrichosis Treated with Photodynamic Therapy: An in Vitro and in Vivo Study

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