1976
DOI: 10.1016/s0092-1157(76)80005-4
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A reference, inactivated, epidemic typhus vaccine: laboratory evaluation of candidate vaccines

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Cited by 4 publications
(1 citation statement)
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“…The potency tests required by the Food and Drug Administration for release of production lots of these vaccines assayed antibodies to R. rickettsii or R. prowazekii by a particular cumbersome method, the titer of neutralization by the sera of immunized guinea pigs of rickettsial “toxicity” to mice [16]. This approach utilized a curious animal model that does not represent rickettsial infection, the death of mice inoculated intravenously with an extremely high dose of rickettsiae in less than 24 h. However, contemporary knowledge reveals that the rickettsial antigens that were critical to neutralizing this effect are conformational epitopes of outer membrane proteins (Omp) A and B for R. rickettsii and OmpB for R. prowazekii [17].…”
Section: Introductionmentioning
confidence: 99%
“…The potency tests required by the Food and Drug Administration for release of production lots of these vaccines assayed antibodies to R. rickettsii or R. prowazekii by a particular cumbersome method, the titer of neutralization by the sera of immunized guinea pigs of rickettsial “toxicity” to mice [16]. This approach utilized a curious animal model that does not represent rickettsial infection, the death of mice inoculated intravenously with an extremely high dose of rickettsiae in less than 24 h. However, contemporary knowledge reveals that the rickettsial antigens that were critical to neutralizing this effect are conformational epitopes of outer membrane proteins (Omp) A and B for R. rickettsii and OmpB for R. prowazekii [17].…”
Section: Introductionmentioning
confidence: 99%