A Reference Guide to Medicinal Plants

Crellin, John K.; Philpott, Jane; Bass, A. L. Tommie

doi:10.1215/9780822379690

Cited by 10 publications

(6 citation statements)

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“…In traditional European medicine M. officinalis was used as a calming and strengthening remedy and to treat migraines, melancholia, neuroses and hysteria, and the plant has been acclaimed for promoting long life and for restoring memory (Bisset, 1994;Kenner and Requena, 1996;McVicar, 1994;Yarnell, 1998). In 1751, the herbalist John Hill stated that M. officinalis was 'Good for disorders of the head and stomach' (Crellin and Philpott, 1990), indicating potential benefits for the use of Melissa officinalis for CNS disorders. In Arabic medicine it was used to treat depression (McVicar, 1994), and it was also used traditionally in Greek medicine to treat hysteria (Malamas and Marselos, 1992).…”

Section: Melissa Officinalis Lmentioning

confidence: 99%

Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders

Howes

Perry

Houghton

2003

Phytotherapy Research

351

241

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In traditional practices of medicine, numerous plants have been used to treat cognitive disorders, including neurodegenerative diseases such as Alzheimer's disease (AD) and other memory related disorders. An ethnopharmacological approach has provided leads to identifying potential new drugs from plant sources, including those for memory disorders. There are numerous drugs available in Western medicine that have been directly isolated from plants, or are derived from templates of compounds from plant sources. For example, some alkaloids from plant sources have been investigated for their potential in AD therapy, and are now in clinical use (e.g. galantamine from Galanthus nivalis L. is used in the United Kingdom). Various other plant species have shown favourable effects in AD, or pharmacological activities indicating the potential for use in AD therapy. This article reviews some of the plants and their active constituents that have been used in traditional medicine, including Ayurvedic, Chinese, European and Japanese medicine, for their reputed cognitive-enhancing and antidementia effects. Plants and their constituents with pharmacological activities that may be relevant to the treatment of cognitive disorders, including enhancement of cholinergic function in the central nervous system, anti-cholinesterase (anti-ChE), antiinflammatory, antioxidant and oestrogenic effects, are discussed.

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Section: Melissa Officinalis Lmentioning

confidence: 99%

Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders

Howes

Perry

Houghton

2003

Phytotherapy Research

351

241

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“…The fruit of the American cranberry ( Vaccinium macrocarpon L.) has been anecdotally reported as a natural remedy for urinary tract infections for centuries 5 6 . Accordingly, a growing number of studies have examined the potential anti-oxidant 7 , anti-adhesion 8 9 10 11 , anti-motility 12 13 14 15 16 17 and anti-cancer 18 19 properties of cranberry-derived compounds.…”

mentioning

confidence: 99%

Cranberry-derived proanthocyanidins impair virulence and inhibit quorum sensing of Pseudomonas aeruginosa

Maisuria

Santos

Tufenkji

et al. 2016

Sci Rep

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Bacteria have evolved multiple strategies for causing infections that include producing virulence factors, undertaking motility, developing biofilms, and invading host cells. N-acylhomoserine lactone (AHL)-mediated quorum sensing (QS) tightly regulates the expression of multiple virulence factors in the opportunistic pathogenic bacterium Pseudomonas aeruginosa. Thus, inhibiting QS could lead to health benefits. In this study, we demonstrate an anti-virulence activity of a cranberry extract rich in proanthocyanidins (cerPAC) against P. aeruginosa in the model host Drosophila melanogaster and show this is mediated by QS interference. cerPAC reduced the production of QS-regulated virulence determinants and protected D. melanogaster from fatal infection by P. aeruginosa PA14. Quantification of AHL production using liquid chromatography-mass spectrometry confirmed that cerPAC effectively reduced the level of AHLs produced by the bacteria. Furthermore, monitoring QS signaling gene expression revealed that AHL synthases LasI/RhlI and QS transcriptional regulators LasR/RhlR genes were inhibited and antagonized, respectively, by cerPAC. Molecular docking studies suggest that cranberry-derived proanthocyanidin binds to QS transcriptional regulators, mainly interacting with their ligand binding sites. These findings provide insights into the underlying mechanisms of action of a cerPAC to restrict the virulence of P. aeruginosa and can have implications in the development of alternative approaches to control infections.

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“…Here, we report that a purified cranberry proanthocyanidin (cPAC) fraction potentiates the activity of a broad range of antibiotic classes against the opportunistic pathogens Escherichia coli, Proteus mirabilis, and Pseudomonas aeruginosa. [6,7] cPAC are condensed tannins that can hinder bacterial attachment to cellular or biomaterial surfaces, [8][9][10][11] impair bacterial motility, [12][13][14][15][16][17] induce a state of iron limitation, [18] and interfere with quorum sensing. Remarkably, when combined with tetracycline, cPAC was able to completely prevent the evolution of resistance in E. coli and P. aeruginosa.…”

mentioning

confidence: 99%

“…[6,7] cPAC are condensed tannins that can hinder bacterial attachment to cellular or biomaterial surfaces, [8][9][10][11] impair bacterial motility, [12][13][14][15][16][17] induce a state of iron limitation, [18] and interfere with quorum sensing. [6,7] cPAC are condensed tannins that can hinder bacterial attachment to cellular or biomaterial surfaces, [8][9][10][11] impair bacterial motility, [12][13][14][15][16][17] induce a state of iron limitation, [18] and interfere with quorum sensing.…”

mentioning

confidence: 99%

Proanthocyanidin Interferes with Intrinsic Antibiotic Resistance Mechanisms of Gram‐Negative Bacteria

et al. 2019

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Antibiotic resistance is spreading at an alarming rate among pathogenic bacteria in both medicine and agriculture. Interfering with the intrinsic resistance mechanisms displayed by pathogenic bacteria has the potential to make antibiotics more effective and decrease the spread of acquired antibiotic resistance. Here, it is demonstrated that cranberry proanthocyanidin (cPAC) prevents the evolution of resistance to tetracycline in Escherichia coli and Pseudomonas aeruginosa , rescues antibiotic efficacy against antibiotic‐exposed cells, and represses biofilm formation. It is shown that cPAC has a potentiating effect, both in vitro and in vivo, on a broad range of antibiotic classes against pathogenic E. coli , Proteus mirabilis , and P. aeruginosa . Evidence that cPAC acts by repressing two antibiotic resistance mechanisms, selective membrane permeability and multidrug efflux pumps, is presented. Failure of cPAC to potentiate antibiotics against efflux pump‐defective mutants demonstrates that efflux interference is essential for potentiation. The use of cPAC to potentiate antibiotics and mitigate the development of resistance could improve treatment outcomes and help combat the growing threat of antibiotic resistance.

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A Reference Guide to Medicinal Plants

Cited by 10 publications

References 0 publications

Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders

Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders

Cranberry-derived proanthocyanidins impair virulence and inhibit quorum sensing of Pseudomonas aeruginosa

Proanthocyanidin Interferes with Intrinsic Antibiotic Resistance Mechanisms of Gram‐Negative Bacteria

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