A Reëxamination of the Rôle of the Stomach in the Digestion of Carbohydrate and Protein

Abstract

The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

The site of receptors slowing gastric emptying in response to starch in test meals

“…The simplest way of harmonizing these observations with the hypothesis of osmotic control of gastric emptying is to suppose that the starch in the test meal was hydrolysed before it was presented to the receptors which responded to the osmotic pressure. Since in the present experiments, in contrast to those of Beazell (1941) under more normal conditions, there was very little hydrolysis of starch in the stomach, the results make it probable that the receptors responding to starch lie at or beyond the pylorus. This conclusion is in agreement with that of Shay et al (1942), who found that the slowing of emptying was produced by instilling solutions hyperosmotic to plasma into the duodenum.…”

Some Aspects of Gastric Function in the Newborn

“…In older children conditions are still far from favourable for any advanced degree of gastric hydrolysis of cow's milk protein (Wolman, 1946), and a consideration of the work of Beazell (1941) and of Borgstrom, Dahlquist, Lundh and Sjovall (1957) indicates that even in adults optimal conditions are by no means invariably attained.…”

Effects of Hydrochlorides of Amino Acids in Test Meals on Gastric Emptying

“…Protein is, at least in dogs, an effective stimulus to the secretion of acid by the stomach (11), but after 60 min in man, less than 5% of the protein in a meal in the stomach is in a form of amino acids and oligo peptides (2). This propor tion presumably increases as time passes.…”

“…Their action is believed to depend upon the stimu lation of osmoreceptors in the walls of the duodenum (4,8). Although gastric digestion of protein (2) probably releases only few amino acids, there will also be sites on oligopeptides which can, at the pH of the stomach, form hydro chlorides. The chloride will of course remain in the ionic state.…”