2017
DOI: 10.1097/nmd.0000000000000544
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A Reexamination of Nonpsychiatric Medication Adherence in Individuals With Bipolar Disorder and Medical Comorbidities

Abstract: Individuals with bipolar disorder (BD) have high rates of non-adherence, medical illness, and premature mortality. This analysis reexamined correlates of poor adherence to non-psychiatric medication in 73 patients with BD and medical comorbidities. The majority was female (74%) and African-American (77%) with mean age of 48.08 (SD = 8.04), mean BD duration of 28.67 years (SD = 10.24), mean years of education of 12.01 (SD = 1.87), and mean proportion of days with missed doses in past week of 43.25 (SD = 31.14).… Show more

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Cited by 14 publications
(6 citation statements)
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References 41 publications
(52 reference statements)
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“…Additionally, the negative consequences of not taking medication, especially for blood pressure control, was a clear motivator to remain adherent. Finally, several participants noted that at times they are adherent to BD medication and not HTN, or vice versa, which is consistent with the literature [40, 41] and suggests that texts to support adherence alone may not be sufficient to change behavior.…”
Section: Discussionsupporting
confidence: 79%
“…Additionally, the negative consequences of not taking medication, especially for blood pressure control, was a clear motivator to remain adherent. Finally, several participants noted that at times they are adherent to BD medication and not HTN, or vice versa, which is consistent with the literature [40, 41] and suggests that texts to support adherence alone may not be sufficient to change behavior.…”
Section: Discussionsupporting
confidence: 79%
“…For instance, lithium is associated with a reduced risk of cerebrovascular diseases and cardiovascular diseases in patients with bipolar disorder (Lan et al, 2015; Prosser and Fieve, 2016), likely through the inhibition of proinflammatory responses, reactive oxidative stress and endothelial dysfunction (Kim et al, 2015; Lee et al, 2014). Furthermore, adjunctive psychosocial therapy can prevent relapse and enhance mood stability (Miklowitz et al, 2021), which in turn improves adherence to somatic treatment in patients with bipolar disorder (Levin et al, 2017). Few studies have evaluated whether contact with the mental health system or a specific treatment modality offers protective effects against cardiovascular risk factors in the bipolar disorder population.…”
Section: Discussionmentioning
confidence: 99%
“…An association between polypharmacy and nonadherence was found in bipolar disorder [25][26][27]. Taking more drugs for bipolar disorder was also associated with worse adherence with nonpsychiatric drugs [28]. The total number of psychiatric drugs and pill burden were also associated with irregularity in the daily dosage taken of antidepressants, mood stabilizers, and antipsychotics in patients with bipolar disorder [29,30].…”
Section: Discussionmentioning
confidence: 99%