A Reevaluation of the Role of Mycoplasmas in Human Disease

Stanbridge, Eric J.

doi:10.1146/annurev.mi.30.100176.001125

Cited by 22 publications

(6 citation statements)

References 60 publications

(74 reference statements)

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“…This review will focus on pathogenicity factors associated with the mycoplasmas themselves and will not discuss host reactions known to play an important role in the pathogenesis of mycoplasma infections. The reader is referred to several recent reviews and symposia on pathogenicity of mycoplasmas in humans and animals (25,76,89,186,312,349) and in plants (21).…”

Section: Factors Involved Inmentioning

confidence: 99%

The mycoplasmas.

Razin¹

1978

Microbiological Reviews

217

135

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Section: Factors Involved Inmentioning

confidence: 99%

The mycoplasmas.

Razin¹

1978

Microbiological Reviews

217

135

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“…Mycoplasmas, a group of diverse species within the class Mollicutes, are small, cell wall-less prokaryotes which adhere to and colonize the epithelial linings of the human respiratory, gastrointestinal, and urogenital tracts (25). Attachment to host cells is a critical process in infection, comprising several steps which lead to successful tissue parasitism (6).…”

mentioning

confidence: 99%

Cytoadhesins of Mycoplasma hominis

1993

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The mechanism of Mycoplasma hominis adherence to host cells of the urogenital tract was investigated with monoclonal antibodies (MAbs) directed against antigenic surface-localized polypeptides P50, P60, P80, and P100 of cytoadherent M. hominis FBG. A cell enzyme-linked immunosorbent assay was established allowing quantification of cytoadherent mycoplasmas detected by one of the following MAbs: four MAbs directed against P100 (molecular weight, about 100,000), three MAbs against P80, one MAb against P60, and three MAbs against P50. MAb binding to one of the surface proteins resulted in a decrease of mycoplasmal adherence to HeLa cells. To exclude the thesis that this is caused by nonspecific blocking of adherence, P100 and P50 were purified by affinity chromatography and tested instead of intact mycoplasmas in the cell enzyme-linked immunosorbent assay for cytoadherence. Both proteins bound to the surface of the eukaryotic cells. MAb binding to single epitopes of these proteins resulted in inhibition of protein adherence. These experiments strongly suggest that of the four surface-localized proteins at least P100 and P50 are adhesins of M. hominis FBG.

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“…3). DISCUSSION Although M. pneumoniae, the major etiological agent of primary atypical pneumonia, is the only mycoplasma of proven pathogenicity to humans, the possible role of other mycoplasmal species in human disease has been the subject of numerous investigations during recent decades (12,28). In the Introduction, mention was made briefly of findings that strongly suggest that M. hominis, and possibly U. urealyticum, may be etiologically involved in salpingitis and other inflammatory conditions of the female genital tract.…”

Section: Resultsmentioning

confidence: 99%

Experimental infection of the genital tract of female grivet monkeys by Mycoplasma hominis

Møller¹,

Freundt²,

Black³

et al. 1978

Infect Immun

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Mycoplasma hominis, a common inhabitant of the mucosae of the genitourinary tract of human and nonhuman primates, was inoculated directly into the uterine tubes of five laparotomized grivet monkeys. A self-limiting acute salpingitis and parametritis developed within a few days in all animals. Although there were no clinical signs of overt disease, the gross pathology was characterized by pronounced oedematous swelling and hyperaemia of the tubes and parametria. Microscopically, cellular infiltrations of lymphocytes and some polymorphonuclear leukocytes were found in the acute phase in the subserosa and muscularis of the tubes and in the parametria. Granulation tissue and fat necrosis appeared at a later stage in the parametria. The infection was associated with a marked antibody response and a moderate rise of the erythrocyte sedimentation rate and leukocyte counts. The capability of M. hominis to produce salpingitis and parametritis in a nonhuman primate would seem to add rather significantly to the available evidence suggesting an etiological role of this organism in inflammatory diseases of the internal female genitals of humans.

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A Reevaluation of the Role of Mycoplasmas in Human Disease

Cited by 22 publications

References 60 publications

The mycoplasmas.

The mycoplasmas.

Cytoadhesins of Mycoplasma hominis

Experimental infection of the genital tract of female grivet monkeys by Mycoplasma hominis

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