A reevaluation of intervestibular nuclear coupling: its role in vestibular compensation

Galiana, Henrietta L.; Flohr, H.; Jones, G. Melvill

doi:10.1152/jn.1984.51.2.242

Cited by 123 publications

(49 citation statements)

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“…Commissural inhibition sets up the push-pull circuitry that underlies the bilaterality of the VOR and is thought to support recovery of the VOR after labyrinthectomy or canal plug (Bienhold and Flohr, 1978;Galiana et al, 1984;Furuya et al, 1992) (but see Smith et al, 1986). We hypothesized that the differences in physiology between YFP-16 and GIN neurons might reflect their circuit roles: perhaps one sends projections contralaterally, whereas the other does not.…”

Section: Both Yfp-16 and Gin Neurons Project Commissurallymentioning

confidence: 99%

Transgenic Mouse Lines Subdivide Medial Vestibular Nucleus Neurons into Discrete, Neurochemically Distinct Populations

Bagnall¹,

Stevens²,

du³

2007

J. Neurosci.

123

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The identification of neuron types within circuits is fundamental to understanding their relevance to behavior. In the vestibular nuclei, several classes of neurons have been defined in vivo on the basis of their activity during behavior, but it is unclear how those types correspond to neurons identified in slice preparations. By targeting recordings to neurons labeled in transgenic mouse lines, this study reveals that the continuous distribution of intrinsic parameters observed in medial vestibular nucleus (MVN) neurons can be neatly subdivided into two populations of neurons, one of which is GABAergic and the other of which is exclusively glycinergic or glutamatergic. In slice recordings, GABAergic neurons labeled in the EGFP (enhanced green fluorescent protein)-expressing inhibitory neuron (GIN) line displayed lower maximum firing rates (Ͻ250 Hz) than glycinergic and glutamatergic neurons labeled in the yellow fluorescent protein-16 (YFP-16) line (up to 500 Hz). In contrast to cortical and hippocampal interneurons, GABAergic MVN neurons exhibited wider action potentials than glutamatergic (and glycinergic) neurons. Responses to current injection differed between the neurons labeled in the two lines, with GIN neurons modulating their firing rates over a smaller input range, adapting less during steady depolarization, and exhibiting less rebound firing than YFP-16 neurons. These results provide a scheme for robust classification of unidentified MVN neurons by their physiological properties. Finally, dye labeling in slices shows that both GABAergic and glycinergic neurons project to the contralateral vestibular nuclei, indicating that commissural inhibition is accomplished through at least two processing streams with differential input and output properties.

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Section: Both Yfp-16 and Gin Neurons Project Commissurallymentioning

confidence: 99%

Transgenic Mouse Lines Subdivide Medial Vestibular Nucleus Neurons into Discrete, Neurochemically Distinct Populations

Bagnall¹,

Stevens²,

du³

2007

J. Neurosci.

123

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“…Many of these symptoms disappear over time in a process called vestibular compensation; postural and spontaneous oculomotor symptoms mostly disappear in several days in the early phase of vestibular compensation, whereas some residual symptoms gradually disappear over the ensuing weeks or months (Darlington et al, 1991;Dieringer, 1995). Because UL results in a permanent loss of vestibular inputs from the lesioned side, the compensatory process is assumed to be attributable to the reorganization of the neural network in the central vestibular system (Galiana et al, 1984;Ris et al, 1995). Many brain regions, such as the medial vestibular nucleus (MVN) and inferior olivary complex, are implicated in this process (Kaufman et al, 1992;Cirelli et al, 1996;Balaban and Romero, 1998).…”

Section: Abstract: Vestibular Compensation; Labyrinthectomy; Lesionimentioning

confidence: 99%

Spatiotemporal Dynamics of Brain-Derived Neurotrophic Factor mRNA Induction in the Vestibulo-Olivary Network during Vestibular Compensation

Li¹,

Hashimoto²,

Tokuyama

et al. 2001

J. Neurosci.

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Vestibular compensation, which is the behavioral recovery from vestibular dysfunction produced by unilateral labyrinthectomy (UL), is attributed to functional and structural reorganization of neural networks in the central vestibular system. To assess the possible contribution of brain-derived neurotrophic factor (BDNF) to this recovery process, we investigated changes in mRNA expression levels in the central vestibular system after UL. We evaluated BDNF mRNA expression levels by quantitative reverse transcription-PCR and in situ hybridization. We found that BDNF mRNA is differentially induced in the medial vestibular nucleus ipsilateral to UL and in the prepositus hypoglossi and inferior olive on the contralateral side. The BDNF mRNA induction lasted for at least 24 hr and returned to the basal expression level within 72 hr after UL. In contrast to BDNF mRNA induction, the expression of an immediate-early gene, c-fos, quickly reached the maximum level at 3 hr and decreased to the basal level within 24 hr after UL. Neither BDNF or c-fos induction was observed in sham-operated animals. The persistent induction of BDNF after UL temporally corresponded to early behavioral manifestations of vestibular compensation. We further found that trkB mRNA was expressed in the central vestibular network at high levels, although its expression levels did not change over time after UL. Because BDNF is implicated in regulating synaptic structure and function, these results provide support for the hypothesis that BDNF is involved in neuronal reorganization that allows vestibular compensation.

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“…A number of behavioral studies, including those discussed here, have led to predictions about the behavior of central neurons in compensated monkeys [14,25,27,29,31,[33][34][35][36] . None of these models of the central mechanisms of compensation have been tested directly at the cellular level in primates.…”

Section: Rotational Vestibulo-ocular Reflexmentioning

confidence: 99%

What Peripheral Vestibular Manipulations Reveal about the Function and Plasticity in the Primate Oculomotor System

Newlands

Angelaki

2004

Neuroembryol Aging

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Central to our understanding of the function and dysfunction of the vestibular system are results from experiments where distinct manipulations of the peripheral vestibular apparatus have been used to characterize deficits and recovery of neural and reflexive responses. Using the primate oculomotor system as a focus, we summarize here recent advances where peripheral vestibular manipulations have revealed important properties of vestibular function and adaptability.

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A reevaluation of intervestibular nuclear coupling: its role in vestibular compensation

Cited by 123 publications

References 0 publications

Transgenic Mouse Lines Subdivide Medial Vestibular Nucleus Neurons into Discrete, Neurochemically Distinct Populations

Transgenic Mouse Lines Subdivide Medial Vestibular Nucleus Neurons into Discrete, Neurochemically Distinct Populations

Spatiotemporal Dynamics of Brain-Derived Neurotrophic Factor mRNA Induction in the Vestibulo-Olivary Network during Vestibular Compensation

What Peripheral Vestibular Manipulations Reveal about the Function and Plasticity in the Primate Oculomotor System

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