A reduced lymphocyte ratio as an early marker for predicting acute pancreatitis

Qi, Xiuzhong; Yang, Feng; Huang, Haitao; Du, Yiqi; Chen, Yan; Wang, Meitang; Zhu, Dong‐Ya; Yue, Xiao-Qiang; Wang, Lina

doi:10.1038/srep44087

Cited by 12 publications

(8 citation statements)

References 25 publications

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“…[ 20 ] A study examining the result of lymphocyte percentage on prognosis in AP patients shows that the percentage of lymphocytes could be differentiated between mild and severe AP, and a lower lymphocyte ratio was detected in severe AP patients. [ 21 ]…”

Section: Discussionmentioning

confidence: 99%

Predictive power of HALP score in estimating short-term mortality in patients with acute pancreatitis

Güler

2023

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: To examine the hemoglobin, albumin, lymphocyte, and platelet (HALP) scores’ predictive power in predicting short-term mortality from acute pancreatitis (AP). METHODS: The study was conducted at the emergency department (ED) of tertiary care hospital. The medical records of patients who admitted to the ED and were diagnosed with AP were reviewed retrospectively. İt was analyzed that the ability of the HALP score in predicting short-term mortality of these patients. RESULTS: The study was achieved with a total of 634 patients. The mean age of these patients was 59.7±16.6 and 381 (60.1%) were female. While 42 (6.6%) of the total included patients were required to the intensive care unit, 58 (9.1%) died. To examine the HALP scores’ predictive power in predicting short-term mortality, the Receiver Operating Characteristic (ROC) analysis was utilized. The value of the area under the curve was found as 0.891 (95% CI: 0.833–0.949). When the cut-off value of the HALP score in determining short-term mortality is >15, the Sensitivity of the score was found to be 82.8%, Specificity 86.8%, Positive Predictive Value 38.7%, and Negative Predictive Value 98.0%. CONCLUSION: AP is a disease that requires early diagnosis and adequate treatment if not it can cause a high rate of mortality and morbidity. As a result of this study, it was concluded that the HALP score can be utilized during the prediction of short-term mortality for patients diagnosed with AP.

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Section: Discussionmentioning

confidence: 99%

Predictive power of HALP score in estimating short-term mortality in patients with acute pancreatitis

Güler

2023

Ulus Travma Acil Cerrahi Derg

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“…Some scholars found that lymphocyte ratio is markedly different between SAP and MAP patients and is valuable for the early differential diagnosis of SAP. [ 14 ] It is known that Th17 and Treg cells play an essential role in various immune processes, especially inflammation, as well as progression of illness. [ 15 ] Loos et al found that Th17 cells play an important role in the pathogenesis of autoimmune pancreatitis.…”

Section: Discussionmentioning

confidence: 99%

Th17/Treg imbalance in patients with severe acute pancreatitis

Guo

Tang

2020

Medicine

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Background: To investigate the effect of high-volume hemofiltration (HVHF) on Th17/Treg imbalance in patients with severe acute pancreatitis (SAP). Methods: Forty-two patients with SAP were randomly received 24 hours of continuous HVHF (n = 21) or without HVHF (n = 21). At day 28, all 42 patients were divided into survival group (n = 32) and non-survival group (n = 10). Venous blood samples collected at 0, 6, 12, and 24 hours during HVHF treatment (or equivalent time in non-HVHF group) were assessed by flow cytometry to detect Th17 and Treg cells. Concentrations of IL-6, IL-17, IL-10, and TGF-β1 were detected by enzyme-linked immunosorbent assay. Results: Th17%, Treg%, Th17/Treg, and levels of related cytokines were significantly higher in SAP patients than healthy controls ( P < .05), and these changes were more pronounced in SAP patients with multiple organ failure than those with single organ failure ( P < .05). After HVHF treatment, Th17%, Treg%, Th17/Treg, IL-6, IL-17, and IL-10 significantly reduced ( P < .05), while there were no significant changes in non-HVHF group ( P > .05). In addition, acute physiology and chronic health evaluation II and sequential organ failure assessment scores decreased markedly after HVHF treatment. Baselines of Th17%, Treg%, Th17/Treg, and related cytokines were significantly higher in non-survival group than survival group. Both acute physiology and chronic health evaluation I score and IL-6 level were positively correlated with Th17% before and after HVHF treatment ( P < .01). Conclusions: Th17/Treg imbalance is present in SAP and may be correlated with its severity and prognosis. HVHF effectively attenuates the Th17/Treg imbalance in SAP patients. The beneficial effect of HVHF on Th17/Treg imbalance is possibly associated with removing excess inflammatory mediators.

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“…Weitz G (28) 2014 391 Severity Classification Germany Karabulut U (29) 2014 98 Severity Classification Brazil Murilo GB (30) 2016 58 Severity Classification Brazil Sun Y (31) 2015 43 Severity Classification China Zhu Y (32) 2017 3260 Severity Classification China Zeng Y (33) 2014 90 Severity Classification China Li G (34) 2016 35 Diagnosis China Deng LH (16) 2017 70 Severity Classification China Lin S (35) 2017 671 Severity Classification China Qi X (36) 2017 204 Severity Classification China Jia R (37) 2015 85 Severity Classification China Xiao S (38) 2015 153 Diagnosis China Joon HC (39) 2015 153 Severity Classification South Korea Huh JH (40) 2018 191 Severity Classification South Korea Kim BG (41) 2013 50 Severity Classification / Diagnosis South Korea Cho JH (42) 2018 60 Severity Classification South Korea Mikolasevic (43) 2016 198 Severity Classification Croatia Mikolasevic (44) 2016 609 Severity Classification / Diagnosis Croatia Trgo G (45) 2016 40 Severity Classification Croatia Vujasinovic (46) 2014 100 Severity Classification Slovenia María CP (47) 2016 56 Severity Classification Spain Bozhychko (48) 2017 233 Severity Classification Spain Ellery KM (49) 2017 122 Severity Classification / Diagnosis USA Sugimoto M (50) 2015 663 Severity Classification USA Gougol A (51) 2017 500 Severity Classification USA Vipperla K (52) 2017 121 Severity Classification USA Vlada AC (53) 2013 67 Severity Classification USA Buxbaum J (54) 2014 25 Severity Classification USA Buxbaum J (55) 2016 60 Severity Classification USA Dimagno M (56) 2014 223 Diagnosis USA Bishu S (57) 2018 357 Severity Classification USA Bem MD (58) 2016 175 Severity Classification USA Nieminen A …”

Section: Author Publication Year Number Of Participants Adopted Atlanta Revision Criteria Nationalitymentioning

confidence: 99%

The Acceptance of Changes in the Management of Patients With Acute Pancreatitis After the Revised Atlanta Classification

Alves

Ferrazza

Nunes

et al. 2021

Arq. Gastroenterol.

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BACKGROUND: New recommendations for the management of patients with acute pancreatitis were set after the Atlanta Classification was revised in 2012. OBJECTIVE: The aim of the present systematic review is to assess whether these recommendations have already been accepted and implemented in daily medical practices. METHODS: A systematic literature review was carried out in studies conducted with humans and published in English and Portuguese language from 10/25/2012 to 11/30/2018. The search was conducted in databases such as PubMed/Medline, Cochrane and SciELO, based on the following descriptors/Boolean operator: “Acute pancreatitis” AND “Atlanta”. Only Randomized Clinical Trials comprising some recommendations released after the revised Atlanta Classification in 2012 were included in the study. RESULTS: Eighty-nine studies were selected and considered valid after inclusion, exclusion and qualitative evaluation criteria application. These studies were stratified as to whether, or not, they applied the recommendations suggested after the Atlanta Classification revision. Based on the results, 68.5% of the studies applied the recommendations, with emphasis on the application of severity classification (mild, moderately severe, severe); 16.4% of them were North-American and 14.7% were Chinese. The remaining 31.5% just focused on comparing or validating the severity classification. CONCLUSION: Few studies have disclosed any form of acceptance or practice of these recommendations, despite the US and Chinese efforts. The lack of incorporation of these recommendations didn’t enable harnessing the benefits of their application in the clinical practice (particularly the improvement of the communication among health professionals and directly association with the worst prognoses); thus, it is necessary mobilizing the international medical community in order to change this scenario.

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A reduced lymphocyte ratio as an early marker for predicting acute pancreatitis

Cited by 12 publications

References 25 publications

Predictive power of HALP score in estimating short-term mortality in patients with acute pancreatitis

Predictive power of HALP score in estimating short-term mortality in patients with acute pancreatitis

Th17/Treg imbalance in patients with severe acute pancreatitis

The Acceptance of Changes in the Management of Patients With Acute Pancreatitis After the Revised Atlanta Classification

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