A Redox-Triggered Autophagy-Induced Nanoplatform with PD-L1 Inhibition for Enhancing Combined Chemo-Immunotherapy
Ming Li,
Dong Zhao,
Jianqin Yan
et al.
Abstract:Epirubicin (EPI) alone can trigger mildly protective
autophagy
in residual tumor cells, resulting in an immunosuppressive microenvironment.
This accelerates the recurrence of residual tumors and leads to antiprogrammed
death ligand 1 (anti-PD-1)/PD-L1 therapy resistance, posing a significant
clinical challenge in tumor immunotherapy. The combination of checkpoint
inhibitors targeting the PD-1/PD-L1 pathway and amplifying autophagy
presents an innovative approach to tumor treatment, which can prevent
tumor immu… Show more
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